{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:31:59Z","timestamp":1790746319526,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY21H040002"],"award-info":[{"award-number":["LY21H040002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Atopic Dermatitis (AD) is a chronic inflammatory skin disease that affects almost 20% of children and 2 -10% of adults worldwide. Previous studies revealed that Interleukin-6 (IL-6) plays an essential role in autoimmune and chronic inflammatory diseases. This study aims to investigate the associations between IL-6 polymorphisms and AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were collected from 132 AD patients and 100 controls, and single nucleotide polymorphisms (SNPs) in IL-6 (rs2069840 (C\/G), rs2066992 (G\/T), rs2069837 (A\/G) and rs1800796 (G\/C)) were analyzed using Multiplex PCR-Based Next Generation Sequencing (NGS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that the A\/G genotype of IL-6\/rs2069837 was significantly associated with a 1.933-fold increased risk of AD compared to those patients with A\/A genotype (OR 1.933; 95%CI 1.086-3.438; <jats:italic>p<\/jats:italic>=0.024). The combined A\/G-G\/G genotype raised AD risk by 1.856 times compared to patients with the A\/A genotype in dominant model (OR: 1.856; 95% CI: 1.056-3.261; <jats:italic>p<\/jats:italic>=0.030). No association was observed for 3 other SNPs and 4 haplotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggested that the A\/G genotype of IL-6\/rs2069837 was more susceptible to AD than A\/A genotype in Chinese Han children, indicating the risk role of IL-6\/rs2069837 in the occurrence of AD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2023.1156659","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T05:15:11Z","timestamp":1679375711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between IL-6 polymorphisms and Atopic Dermatitis in Chinese Han 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