{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:46:39Z","timestamp":1789429599856,"version":"build-2803163510"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pregnancy represents a state of increased oxidative stress and antioxidants, in which selenium (Se) plays a pivotal role, contribute to maintain the oxidative balance. If antioxidant defenses are depleted, placental function is disrupted, resulting in pregnancy complications, including pregnancy-induced hypertension (PIH). Little is known about fetal selenium status in concomitant relation to maternal PIH, gestational age (GA) and birthweight (BW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined over a 3-year period the serum (SeS) and urine selenium (SeU) status in term neonates from normotensive (nonPIH) and hypertensive (PIH) mothers as clinical markers of oxidative stress. In this retrospective observational study, 72 neonates with maternal PIH were matched for GA and BW to 72 neonates of normotensive mothers. Four groups were obtained, based on maternal PIH and BW relative to GA (appropriate-for-gestational-age\u2014AGA, small-for-gestational-age\u2014SGA): nonPIH-AGA (control group), nonPIH-SGA, PIH-AGA, and PIH-SGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed significant differences (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) in selenium levels among the study groups: SeS - 44.85\u2009\u00b1\u20097.56\u2005\u03bcg\/L in nonPIH-AGA, 39.62\u2009\u00b1\u200911.42\u2005\u03bcg\/L in nonPIH-SGA, 40.01\u2009\u00b1\u200910.07\u2005\u03bcg\/L in PIH-AGA, and 25.39\u2009\u00b1\u20098.99\u2005\u03bcg\/L in PIH-SGA; SeU - 27.98\u2009\u00b1\u20097.99\u2005\u03bcg\/L in nonPIH-AGA, 22.85\u2009\u00b1\u20099.48\u2005\u03bcg\/L in nonPIH-SGA, 23.44\u2009\u00b1\u20096.73\u2005\u03bcg\/L in PIH-AGA, and 13.05\u2009\u00b1\u20095.86\u2005\u03bcg\/L in PIH-SGA. Selenium depletion was more common in neonates born from hypertensive mothers and those born small for gestational age. Though moderate in intensity, selenium levels were positively correlated with BW (0.319 for SeS, 0.397 for SeU) and negatively correlated with maternal systolic blood pressure (\u22120.313 for SeS, \u22120.324 for SeU). The main independent effects on SeS and SeU of each maternal blood pressure and birth weight turned out statistically significant. In interaction, a more pronounced effect was reached in PIH-SGA neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Selenium status seemed to reflect the negative impact that PIH exerts in neonates during intrauterine development. Clinical markers of selenium status could thus be of great value for tracking responses of individuals to selenium supplementation as part of health improvement and harm mitigation approaches.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2023.1157689","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:04:44Z","timestamp":1680188684000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology"],"prefix":"10.3389","volume":"11","author":[{"given":"Teofana Otilia","family":"Bizerea-Moga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pitulice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otilia","family":"Bizerea-Spiridon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"Angelescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otilia","family":"M\u0103rginean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor Voicu","family":"Moga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cbpb.2008.08.009","article-title":"Selenoproteins and maternal nutrition","volume":"151","author":"Pappas","year":"2008","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.pedneo.2012.11.001","article-title":"Impact of maternal selenium supplementation on neonates","volume":"53","author":"Chao","year":"2012","journal-title":"PediatrNeonatology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.pedneo.2012.08.008","article-title":"Effect of prenatal selenium supplementation on cord blood selenium and lipid profile","volume":"53","author":"Boskabadi","year":"2012","journal-title":"Pediatr Neonatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jtemb.2014.07.003","article-title":"The role of selenium in human conception and pregnancy","volume":"29","author":"Pieczy\u0144ska","year":"2015","journal-title":"J Trace Elem Med Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3390\/antiox9050383","article-title":"Role of selenoproteins in redox regulation of signaling and the antioxidant system: a review","volume":"9","author":"Zhang","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.2298\/JSC0809805P","article-title":"Structural features of proteins as reflected by statistical scaling laws","volume":"73","author":"Pitulice","year":"2008","journal-title":"J Serb Chem Soc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.chaos.2007.08.016","article-title":"Scaling properties of the radius of gyration and surface area for ef-hand calcium binding proteins","volume":"40","author":"Pitulice","year":"2009","journal-title":"Chaos Solitons Fractals"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6976","DOI":"10.1073\/pnas.1319022111","article-title":"Redox active motifs in selenoproteins","volume":"111","author":"Li","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1161\/hypertensionaha.108.116103","article-title":"Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies","volume":"52","author":"Mistry","year":"2008","journal-title":"Hypertension"},{"key":"B10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1039\/a704884j","article-title":"Decreased selenium concentration in maternal and cord blood in preterm compared with term delivery","volume":"123","author":"Dobrzynski","year":"1998","journal-title":"Analyst"},{"key":"B11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3389\/fped.2020.00279","article-title":"Relationship between oxidative stress markers and endothelin-1 levels in newborns of different gestational ages","volume":"8","author":"Stefanov","year":"2020","journal-title":"Front Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jtemb.2009.02.005","article-title":"Antioxidants activities and concentration of selenium, zinc and copper in preterm and iugr human placentas","volume":"23","author":"Zadrozna","year":"2009","journal-title":"J Trace Elem Med Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jtemb.2007.10.004","article-title":"Selenium in placenta predicts birth weight in normal but not intrauterine growth restriction pregnancy","volume":"22","author":"Klapec","year":"2008","journal-title":"J Trace Elem Med Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"165354","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5581570","DOI":"10.1155\/2021\/5581570","article-title":"The role of oxidative stress in hypertensive disorders of pregnancy (preeclampsia, gestational hypertension) and metabolic disorder of pregnancy (gestational diabetes Mellitus)","volume":"2021","author":"Phoswa","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.12691\/ajmbr-3-3-1","article-title":"Oxidative stress markers in pregnant women with preeclampsia","volume":"3","author":"de Lucca","year":"2015","journal-title":"Am J Med Biol Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.5455\/medarh.2016.70.437-440","article-title":"Oxidative stress marker and pregnancy induced hypertension","volume":"70","author":"Draganovic","year":"2016","journal-title":"Med Arch"},{"key":"B18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.reprotox.2008.11.057","article-title":"Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities","volume":"27","author":"Llanos","year":"2009","journal-title":"Reprod Toxicol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1385\/bter:99:1-3:071","article-title":"Selenium Status, birth weight, and breast-feeding: pattern in the first month","volume":"99","author":"Strambi","year":"2004","journal-title":"Biol Trace Elem Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.clnu.2003.08.004","article-title":"Selenium concentrations in maternal and umbilical cord blood at 24-42 weeks of gestation: basis for optimization of selenium supplementation to premature infants","volume":"23","author":"Makhoul","year":"2004","journal-title":"Clin Nutr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jtemb.2013.03.006","article-title":"Serum selenium levels of the very low birth weight premature newborn infants with bronchopulmonary dysplasia","volume":"27","author":"Peirovifar","year":"2013","journal-title":"J Trace Elem Med Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.nutres.2006.08.008","article-title":"Low-Normal serum selenium early in human pregnancy predicts lower birth weight","volume":"26","author":"Bogden","year":"2006","journal-title":"Nutr Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/sj.ejcn.1602715","article-title":"Selenium status in term and preterm infants during the first months of life","volume":"62","author":"Loui","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2167-0897.1000116","article-title":"Selenium and vitamin A and E in the nutrition of very low-birth weight preterm infants","volume":"2","author":"Trindade","year":"2013","journal-title":"J Neonatal Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.2223\/1299","article-title":"Minerals in the nutrition of extremely low birth weight infants","volume":"81","author":"Trindade","year":"2005","journal-title":"J Pediatr (Rio J)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/nu14030628","article-title":"Selenoproteins in the human placenta: how essential is selenium to a healthy start to life?","volume":"14","author":"Hogan","year":"2022","journal-title":"Nutrients"},{"key":"B27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s1695-4033(03)78739-6","article-title":"Serum selenium levels in neonates","volume":"59","author":"Guirado Gim\u00e9nez","year":"2003","journal-title":"An Pediatr (Barc)"},{"key":"B28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.epag.2018.10.001","article-title":"Comparison between preterm and full term neonatal cord selenium in correlation to maternal serum selenium levels","volume":"66","author":"Bebars","year":"2018","journal-title":"Egypt Pediatr Assoc Gazette"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.21608\/ejhm.2022.241712","article-title":"The assessment of cord blood selenium level in preterm and full-term neonates","volume":"88","author":"Bakir","year":"2022","journal-title":"Egypt J Hosp Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.3390\/nu14153082","article-title":"Selenium Status and supplementation effects in pregnancy-a study on mother-child pairs from a single-center cohort","volume":"14","author":"Filipowicz","year":"2022","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41372-017-0033-3","article-title":"Selenium: implications for outcomes in extremely preterm infants","volume":"38","author":"Tindell","year":"2018","journal-title":"J Perinatol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"105218","DOI":"10.1016\/j.envint.2019.105218","article-title":"Urine selenium concentration is a useful biomarker for assessing population level selenium Status","volume":"134","author":"Phiri","year":"2019","journal-title":"Environ Int"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/nu13051497","article-title":"Evaluation of serum selenium status by age and gender: a retrospective observational cohort study in western Romania","volume":"13","author":"Bizerea-Moga","year":"2021","journal-title":"Nutrients"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/nu7042209","article-title":"Biomarkers of selenium status","volume":"7","author":"Combs","year":"2015","journal-title":"Nutrients"},{"key":"B35","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3390\/antiox11050973","article-title":"The role and mechanism of essential selenoproteins for homeostasis","volume":"11","author":"Ye","year":"2022","journal-title":"Antioxidants"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"B37","doi-asserted-by":"publisher","first-page":"S630","DOI":"10.1016\/j.ajog.2018.01.011","article-title":"The intergrowth-21(st) fetal growth standards: toward the global integration of pregnancy and pediatric care","volume":"218","author":"Papageorghiou","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1097\/hjh.0000000000002711","article-title":"Postpartum health risks among women with hypertensive disorders of pregnancy, California 2008-2012","volume":"39","author":"Murray Horwitz","year":"2021","journal-title":"J Hypertens"},{"key":"B39","year":"2017"},{"key":"B40","first-page":"5","article-title":"Caesarean birth in Romania: safe motherhood between ethical, medical and statistical arguments","volume":"12","author":"Simionescu","year":"2017","journal-title":"Maedica (Bucur)"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.3390\/ijerph20032705","article-title":"Development of a framework for on-demand caesarean section in Romania","volume":"20","author":"Petre","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21203\/rs.3.rs-39240\/v3","article-title":"Who indicates caesarean section in Romania? A cross-sectional survey in tertiary level maternity on childbirth patients and doctors\u2019 profiles","author":"Simionescu","year":"2020","journal-title":"Res Sq"},{"key":"B43","volume-title":"Hypertensive disorders. Williams obstetrics, 24e","author":"Cunningham","year":"2013"},{"key":"B44","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/bf02784266","article-title":"Bioavailability of enteral yeast-selenium in preterm infants","volume":"65","author":"Bogye","year":"1998","journal-title":"Biol Trace Elem Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13044-020-00090-x","article-title":"Selenium and at-risk pregnancy: challenges and controversies","volume":"13","author":"Duntas","year":"2020","journal-title":"Thyroid Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1590\/s0103-05822014000100019","article-title":"Selenium deficiency and the effects of supplementation on preterm infants","volume":"32","author":"Freitas","year":"2014","journal-title":"Rev Paul Pediatr"},{"key":"B47","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.earlhumdev.2005.01.007","article-title":"Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages","volume":"81","author":"Galinier","year":"2005","journal-title":"Early Hum Dev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0022-3476(89)80154-4","article-title":"Selenium deficiency in low birth weight neonates: an unrecognized problem","volume":"114","author":"Lockitch","year":"1989","journal-title":"J Pediatr"},{"key":"B49","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S0271-5317(05)80593-7","article-title":"Selected measures of selenium status in full-term and preterm neonates, their mothers and nonpregnant women","volume":"13","author":"Mask","year":"1993","journal-title":"Nutr Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e75627","DOI":"10.1371\/journal.pone.0075627","article-title":"Associations of maternal and neonatal serum trace element concentrations with neonatal birth weight","volume":"8","author":"Tsuzuki","year":"2013","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/jes.2011.42","article-title":"Selenium and maternal blood pressure during childbirth","volume":"22","author":"Wells","year":"2012","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/09603129873372","article-title":"Serum selenium levels in Saudi new-borns","volume":"8","author":"Al-Saleh","year":"1998","journal-title":"Int J Environ Health Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13052-015-0185-8","article-title":"Correlations between maternal and neonatal Serum selenium levels in full term neonates with hypoxic ischemic encephalopathy","volume":"41","author":"El-Mazary","year":"2015","journal-title":"Ital J Pediatr"},{"key":"B54","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/biof.5520080123","article-title":"Randomized clinical trial of enteral yeast-selenium supplementation in preterm infants","volume":"8","author":"Bogye","year":"1998","journal-title":"Biofactors"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.3390\/nu12092678","article-title":"A review of the potential interaction of selenium and iodine on placental and child health","volume":"12","author":"Habibi","year":"2020","journal-title":"Nutrients"},{"key":"B56","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajog.2011.07.034","article-title":"Selenium in reproductive health","volume":"206","author":"Mistry","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.placenta.2010.02.011","article-title":"Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy","volume":"31","author":"Mistry","year":"2010","journal-title":"Placenta"},{"key":"B58","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5601\/brak98","article-title":"Effect of maternal selenium supplementation on pregnancy in humans and livestock","volume":"16","author":"Palmieri","year":"2011","journal-title":"J Elementol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1039\/b903805a","article-title":"The placenta as a barrier for toxic and essential elements in paired maternal and cord blood samples of South African delivering women","volume":"11","author":"Rudge","year":"2009","journal-title":"J Environ Monit"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1017\/s0007114517001155","article-title":"Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth","volume":"117","author":"Santos","year":"2017","journal-title":"Br J Nutr"},{"key":"B61","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4141\/cjas84-248","article-title":"Bidirectional transfer of selenium across the sheep placenta in utero","volume":"64","author":"Shariff","year":"1984","journal-title":"Can J Anim Sci"},{"key":"B62","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.envint.2013.08.007","article-title":"Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure","volume":"60","author":"Sakamoto","year":"2013","journal-title":"Environ Int"},{"key":"B63","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/bf02723929","article-title":"Maternal and cord plasma selenium levels in full-term neonates","volume":"67","author":"Gathwala","year":"2000","journal-title":"Indian J Pediatr"},{"key":"B64","first-page":"1749","article-title":"Research progress regarding the effect of exogenous selenium on vegetables","volume":"39","author":"Zeng-Chao","year":"2012","journal-title":"Acta Horticulturae Sin"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1096\/fj.13-231852","article-title":"Maternal-Fetal transfer of selenium in the mouse","volume":"27","author":"Burk","year":"2013","journal-title":"Faseb j"},{"key":"B66","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1080\/10715760902783285","article-title":"Oxidative stress in small-for-gestational age (sga) term newborns and their mothers","volume":"43","author":"Gveric-Ahmetasevic","year":"2009","journal-title":"Free Radic Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/01.Hyp.0000141085.98320.01","article-title":"Oxidative stress and preeclampsia: rationale for antioxidant clinical trials","volume":"44","author":"Raijmakers","year":"2004","journal-title":"Hypertension"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.7754\/Clin.Lab.2018.180307","article-title":"The link between selenium, oxidative stress and pregnancy induced hypertensive disorders","volume":"64","author":"Bizerea","year":"2018","journal-title":"Clin Lab"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2021.587635","article-title":"A review of biomechanics analysis of the umbilical\u2013placenta system with regards to diseases","volume":"12","author":"Saw","year":"2021","journal-title":"Front Physiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e12653","DOI":"10.1111\/aji.12653","article-title":"Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes","volume":"77","author":"Sultana","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.preghy.2011.07.001","article-title":"Selenium and preeclampsia: a global perspective","volume":"1","author":"Vanderlelie","year":"2011","journal-title":"Pregnancy Hypertens"},{"key":"B72","unstructured":"The trace elements selenium, copper and zinc in pediatric practice\n          \n            van Caillie-BertrandM\n          Erasmus University Rotterdam[Ph.D. Thesis]1985"},{"key":"B73","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/nu14010204","article-title":"Extreme birth weight and metabolic syndrome in children","volume":"14","author":"Bizerea-Moga","year":"2022","journal-title":"Nutrients"},{"key":"B74","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/s1472-6483(10)62151-7","article-title":"Role of free radicals in female reproductive diseases and assisted reproduction","volume":"9","author":"Agarwal","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.2903\/j.efsa.2014.3846","article-title":"Scientific opinion on dietary reference values for selenium","volume":"12","year":"2014","journal-title":"EFSA J"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2023.1157689\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:04:52Z","timestamp":1680188692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2023.1157689\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":75,"alternative-id":["10.3389\/fped.2023.1157689"],"URL":"https:\/\/doi.org\/10.3389\/fped.2023.1157689","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"article-number":"1157689"}}