{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T23:39:29Z","timestamp":1788737969127,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the correlation between mitochondria parameters of immune cells and hyperbilirubinemia risk in hospitalized neonates with jaundice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included jaundiced neonates born between September 2020 and March 2022 at Shaoxing Keqiao Women &amp;amp; Children's Hospital. The neonates were divided into low, intermediate-low, intermediate-high, and high-risk groups according to the hyperbilirubinemia risk. The purpose parameters including percentage, absolute count, mitochondrial mass (MM), and single-cell MM (SCMM) of peripheral blood T lymphocytes detected by flow cytometry were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Finally, 162 neonates with jaundice (47, 41, 39, and 35 with low, intermediate-low, intermediate-high, and high-risk) were included. CD3\n                      <jats:sup>+<\/jats:sup>\n                      SCMM was significantly higher in the high-risk group compared with the low and intermediate-low-risk groups (both\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &amp;lt;\u20090.0083), CD4\n                      <jats:sup>+<\/jats:sup>\n                      SCMM was significantly higher in the high-risk group compared with the three other groups (all\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &amp;lt;\u20090.0083), and CD8\n                      <jats:sup>+<\/jats:sup>\n                      SCMM was significantly higher in the intermediate-low and high-risk groups compared with the low-risk group (both\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &amp;lt;\u20090.0083). CD3\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.34,\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &amp;lt;\u20090.001) and CD4\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.20,\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.010) SCMM positively correlated with bilirubin levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The mitochondrial SCMM parameters differed significantly among jaundiced neonates with different hyperbilirubinemia risks. CD3\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell SCMM values were positively correlated with the serum bilirubin levels, and might correlated with hyperbilirubinemia risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2023.1200099","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T05:38:28Z","timestamp":1686893908000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between hyperbilirubinemia risk and immune cell mitochondria parameters in neonates with 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