{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:03:08Z","timestamp":1787320988073,"version":"build-2736575974"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    <jats:italic>Aeromonas caviae<\/jats:italic>\n                    infection of the bloodstream and intestine is a rare and severe opportunistic infection in immunocompromised people. In Southwest China, we first reported a case of bloodstream and intestinal infection with multidrug-resistant (MDR)\n                    <jats:italic>Aeromonas caviae<\/jats:italic>\n                    in a 4-year-old child with T-cell acute lymphoblastic leukemia. Blood and stool cultures were used to identify the infection. The selection of antibiotics was based on clinical expertise and medication sensitivity tests. We used linezolid, levofloxacin, and polymyxin B to treat the patient aggressively.\n                    <jats:italic>Aeromonas caviae<\/jats:italic>\n                    infection is uncommon in juvenile acute lymphoblastic leukemia. Doctors should be aware of the likelihood of opportunistic infection during the post-chemotherapy bone marrow suppression period. We further conducted a review of the literature and performed a detailed analysis of\n                    <jats:italic>Aeromona<\/jats:italic>\n                    s infection in pediatric leukemia. It is becoming increasingly apparent that antibiotic is abused domestically and abroad, resulting in the sharp increase of MDR bacteria. In general, most of the\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    isolates are susceptible to third- or fourth-generation cephalosporins, aminoglycosides, quinolones, and carbapenem, but drug-resistant strains are being reported increasingly. We summarized the drug resistance rate of\n                    <jats:italic>Aeromona<\/jats:italic>\n                    s caviae and\n                    <jats:italic>Aeromonas hydrophila<\/jats:italic>\n                    in China in the last 10 years. Early recognition and effective treatment will improve prognosis and reduce mortality.\n                  <\/jats:p>","DOI":"10.3389\/fped.2024.1233600","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:53:00Z","timestamp":1715561580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: A rare infection of multidrug-resistant Aeromonas caviae in a pediatric case with acute lymphoblastic leukemia and review of the literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Yiling","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"738040","DOI":"10.1016\/j.aquaculture.2022.738040","article-title":"Prevalence, virulence-related genes and antimicrobial resistance of Aeromonas spp. from loach Misgurnus anguillicaudatus with skin ulcer and healthy controls in Southern China","volume":"552","author":"Wang","year":"2022","journal-title":"Aquaculture"},{"key":"B2","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3109\/00365548.2012.737474","article-title":"Aeromonas caviae is the most frequent pathogen amongst cases of Aeromonas bacteremia in Japan","volume":"45","author":"Kimura","year":"2013","journal-title":"Scand J Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1620\/tjem.225.81","article-title":"Clinical characteristics of seven patients with Aeromonas septicemia in a Japanese hospital","volume":"225","author":"Morinaga","year":"2011","journal-title":"Tohoku J Exp Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e111213","DOI":"10.1371\/journal.pone.0111213","article-title":"Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s10096-017-2945-4","article-title":"Clinical significance and outcome of Aeromonas spp. infections among 204 adult patients","volume":"36","author":"Nolla-Salas","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"B6","first-page":"241","article-title":"Outcomes of Aeromonas bacteremia in patients with different types of underlying disease","volume":"33","author":"Lau","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"key":"B7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12879-022-07277-7","article-title":"Clinical characteristics and risk factors of Aeromonas bloodstream infections in patients with hematological diseases","volume":"22","author":"Xu","year":"2022","journal-title":"BMC Infect Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jgar.2017.07.006","article-title":"First report of bla(OXA-181)-mediated carbapenem resistance in Aeromonas caviae in association with pKP3-A: threat for rapid dissemination","volume":"10","author":"Anandan","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"B9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/jam.14485","article-title":"Antimicrobial resistance of pathogenic Aeromonas spp. isolated from marketed pacific abalone (Haliotis discus hannai) in Korea","volume":"128","author":"Wickramanayake","year":"2020","journal-title":"J Appl Microbiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010129","article-title":"An update on the genus Aeromonas: taxonomy, epidemiology, and pathogenicity","volume":"8","author":"Fernandez-Bravo","year":"2020","journal-title":"Microorganisms"},{"key":"B11","doi-asserted-by":"publisher","first-page":"563482","DOI":"10.3389\/fcimb.2020.563482","article-title":"Carbapenem resistant Aeromonas hydrophila carrying bla(cphA7) isolated from two solid organ transplant patients","volume":"10","author":"Hilt","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41375-019-0388-x","article-title":"Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. 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