{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:19Z","timestamp":1753891879039,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Klippel\u2013Tr\u00e9naunay syndrome, a kind of congenital limb-length-discrepancy disorder, is commonly associated with a variety of vascular anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present the case of a three-day-old newborn with a profound abdominal mass lesion during prenatal magnetic resonance imaging (MRI) examination. After delivery, physical examination revealed mild hemihypertrophy of the left lower extremity and red lesions on the left thigh. MRI of the abdomen showed a cyst-like lesion measuring 6.3\u2005cm\u2009\u00d7\u20092.7\u2005cm\u2009\u00d7\u20095.5\u2005cm in the upper abdomen. Within the mass, there were also some possible calcified spots exhibiting high T1WI signals and low T2WI signals. A computed tomography (CT) scan of the abdomen was consistent with an ill-defined cystic tumor with small calcifications and encasement of mesenteric vessels. A MRI of the left lower extremity showed a tubular structure with a signal void and homogeneous strong enhancement located in the anterior subcutis of the left lower limb. The CT scan confirmed that the tubular structure was consistent with a venous malformation. This patient had features of Klippel\u2013Tr\u00e9naunay syndrome, including port-wine stains, a profound abdominal mass, and vascular malformations of the left lower extremity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this article, we presented a case of Klippel\u2013Tr\u00e9naunay syndrome, emphasizing both prenatal and confirmatory postnatal cross-sectional imaging findings. The rare presentation of an abdominal lymphatic-venous formation played a pivotal role as a crucial indicator for an early diagnosis of Klippel\u2013Tr\u00e9naunay syndrome.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1326909","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T04:35:12Z","timestamp":1705638912000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Klippel\u2013Tr\u00e9naunay syndrome with profound abdominal lymphatic-venous malformation in a three-day-old newborn: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Shih Yang","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Shan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1148\/rg.2019180136","article-title":"Congenital limb overgrowth syndromes associated with vascular anomalies","volume":"39","author":"Bertino","year":"2019","journal-title":"Radiographics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.37549\/AR2451","article-title":"Klippel\u2013Tr\u00e9naunay syndrome","volume":"47","author":"Liguori","year":"2018","journal-title":"Appl Radiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/ANC.0b013e3181a68b15","article-title":"Klippel\u2013Tr\u00e9naunay syndrome: a case study","volume":"9","author":"Meier","year":"2009","journal-title":"Adv Neonatal Care"},{"key":"B4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/1742271X19880327","article-title":"Prenatal diagnosis of Klippel\u2013Trenaunay syndrome: series of four cases and review of the literature","volume":"28","author":"Ivanitskaya","year":"2020","journal-title":"Ultrasound"},{"key":"B5","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2214\/ajr.167.4.8819399","article-title":"Klippel\u2013Tr\u00e9naunay syndrome: imaging findings and percutaneous intervention","volume":"167","author":"Kanterman","year":"1996","journal-title":"Am J Radiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s11596-018-1964-4","article-title":"Radiological aspect of Klippel\u2013Tr\u00e9naunay syndrome: a case series with review of literature","volume":"38","author":"Alwalid","year":"2018","journal-title":"Curr Med Sci"},{"key":"B7","first-page":"62","article-title":"Lower gastrointestinal bleeding, hematuria and splenic hemangiomas in Klippel\u2013Tr\u00e9naunay syndrome: a case report and literature review","volume":"20","author":"Kocaman","year":"2009","journal-title":"Turk J Gastroenterol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s13256-021-03029-4","article-title":"A neonate with Klippel\u2013Tr\u00e9naunay syndrome: a case report","volume":"15","author":"Sikakulya","year":"2021","journal-title":"J Med Case Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e8023","DOI":"10.7759\/cureus.8023","article-title":"Presentation and management of Klippel\u2013Trenaunay syndrome: a review of available data","volume":"12","author":"Asghar","year":"2020","journal-title":"Cureus"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e28303","DOI":"10.7759\/cureus.28303","article-title":"Klippel\u2013Tr\u00e9naunay syndrome with atypical presentation of small port-wine stain","volume":"14","author":"Alazawi","year":"2022","journal-title":"Cureus"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1326909\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T04:35:15Z","timestamp":1705638915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1326909\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":10,"alternative-id":["10.3389\/fped.2024.1326909"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1326909","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"article-number":"1326909"}}