{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:26:29Z","timestamp":1778595989846,"version":"3.51.4"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low birth weight has been observed in offspring of alcoholic mothers due likely to unresolved inflammation and oxidative injury. Dietary lipids play a role in inflammation and its resolution. The primary objective was to investigate the effect of DHA and olive oil on the birth weight of pups born to alcohol-exposed dams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant rats were randomized to the control or three treatment (alcohol) groups. From gestational days (GD) 8\u201319, the control group received daily olive oil and malto\/dextrose, whereas groups 2 and 3 received olive oil and low-dose alcohol or high-dose alcohol, respectively. Group 4 received daily DHA and high-dose alcohol. The dam's blood was collected on GD 15 and 20 for cytokine analysis. Dams were sacrificed on GD 20. The mean birth weight of pups was compared by one-way ANOVA with post hoc Duncan's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant increase in the pups' mean birth weight in the high-dose alcohol\/DHA and high-dose alcohol\/olive oil. Higher pro-inflammatory cytokines (IL-1\u03b2 and IL-12p70) were noted in the alcohol-exposed dams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DHA and olive oil supplementation in alcohol-exposed pregnant rats significantly increased their pups' birth weight despite having high pro-inflammatory cytokines. The mechanism of this effect remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1334285","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T04:54:28Z","timestamp":1712206468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of docosahexaenoic acid and olive oil supplementation on pup weight in alcohol-exposed pregnant rats"],"prefix":"10.3389","volume":"12","author":[{"given":"Deepak","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Enrique M.","family":"Ostrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie T.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Kisseih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna R.","family":"Maddipati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00787-014-0571-6","article-title":"Fetal alcohol spectrum disorders","volume":"23","author":"D\u00f6rrie","year":"2014","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejmg.2016.10.004","article-title":"A review of the physical features of the fetal alcohol spectrum disorders","volume":"60","author":"del Campo","year":"2017","journal-title":"Eur J Med Genet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ejmg.2016.09.010","article-title":"Prevalence of alcohol consumption during pregnancy and fetal alcohol spectrum disorders among the general and aboriginal populations in Canada and the United States","volume":"60","author":"Popova","year":"2017","journal-title":"Eur J Med Genet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e290","DOI":"10.1016\/S2214-109X(17)30021-9","article-title":"Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis","volume":"5","author":"Popova","year":"2017","journal-title":"Lancet Glob Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/acer.12939","article-title":"Worldwide prevalence of fetal alcohol spectrum disorders: a systematic literature review including meta-analysis","volume":"40","author":"Roozen","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1053\/siny.2000.0027","article-title":"Alcohol in pregnancy and neonatal outcome","volume":"5","author":"Hannigan","year":"2000","journal-title":"Semin Neonatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0775","article-title":"Fetal alcohol growth restriction and cognitive impairment","volume":"138","author":"Carter","year":"2016","journal-title":"Pediatrics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/acer.13566","article-title":"Effect of hazardous alcohol use during pregnancy on growth outcomes at birth: findings from a South African cohort study","volume":"42","author":"Myers","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/0026-0495(88)90059-5","article-title":"Metabolic response to starvation at late gestation in chronically ethanol-treated and pair-fed undernourished rats","volume":"37","author":"Testar","year":"1988","journal-title":"Metabolism"},{"key":"B10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1530-0277.1990.tb00495.x","article-title":"Effects of prenatal ethanol and long-chain N-3 fatty acid supplementation on development in mice. 1. 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