{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:22Z","timestamp":1753892062742,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Inflammatory myopathies are a rare group of disorders that can cause significant disruption in the ability of an individual to adequately perform activities of daily living. In this case report, we present a case of a girl presenting with a substantial compromise of her ambulation with a muscle biopsy consistent with myonecrosis. She was subsequently diagnosed with an inflammatory myopathy and started on glucocorticoid and methotrexate therapy with minimal symptomatic improvement. Further in her clinical course, hypocalcemia and an undetectable 25-hydroxyvitamin D level were detected. Prompt institution of calcium and vitamin D supplementation significantly improved her myopathic condition. While there is evidence in the literature linking vitamin D deficiency with myopathy, there is a lack of data on the association between hypocalcemia and vitamin D deficiency with myonecrosis, which could represent comorbid states in myonecrosis. Therefore, vitamin D status should be established in all patients with myonecrosis, as vitamin D deficiency is easy to diagnose and treat, as exemplified in our patient\u2019s case, which shows that such treatment could lead to significant clinical improvement.<\/jats:p>","DOI":"10.3389\/fped.2024.1339875","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:29:25Z","timestamp":1707712165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Severe vitamin D deficiency in a girl with inflammatory myopathy and myonecrosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Andrew","family":"Kanouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Udoka","family":"Nwosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parissa","family":"Salemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.braindev.2012.11.014","article-title":"Vitamin D deficiency: a forgotten treatable cause of motor delay and proximal myopathy","volume":"36","author":"Fluss","year":"2014","journal-title":"Brain Dev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.4103\/1947-2714.112491","article-title":"Severe vitamin D deficiency induced myopathy associated with rhabydomyolysis","volume":"5","author":"Rasheed","year":"2013","journal-title":"N Am J Med Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1017\/S0317167100007083","article-title":"Severe proximal myopathy with remarkable recovery after vitamin D treatment","volume":"36","author":"Al-Said","year":"2009","journal-title":"Can J Neurol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s001980200012","article-title":"Vitamin D and muscle function","volume":"13","author":"Pfeifer","year":"2002","journal-title":"Osteoporos Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1001\/archinte.160.8.1199","article-title":"Severe myopathy associated with vitamin D deficiency in Western New York","volume":"160","author":"Prabhala","year":"2000","journal-title":"Arch Intern Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/RHU.0b013e3181c3b2c0","article-title":"Diffuse muscoskeletal pain and proximal myopathy: do not forget hypovitaminosis D","volume":"16","author":"Fabbriciani","year":"2010","journal-title":"J Clin Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4103\/1947-2714.153919","article-title":"Statin intolerance because of myalgia, myositis, myopathy, or myonecrosis can in most cases be safely resolved by vitamin D supplementation","volume":"7","author":"Khayznikov","year":"2015","journal-title":"N Am J Med Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1359\/jbmr.1997.12.12.2082","article-title":"Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women","volume":"12","author":"Geusens","year":"1997","journal-title":"J Bone Miner Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1136\/annrheumdis-2012-201849","article-title":"Low serum levels of vitamin D in idiopathic inflammatory myopathies","volume":"72","author":"Azali","year":"2013","journal-title":"Ann Rheum Dis"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1339875\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:29:28Z","timestamp":1707712168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1339875\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":10,"alternative-id":["10.3389\/fped.2024.1339875"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1339875","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"article-number":"1339875"}}