{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:15:18Z","timestamp":1764731718390,"version":"3.41.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Programs that aim to improve the detection hypoxic-ischemic encephalopathy (HIE) should establish which neonates suffering from perinatal asphyxia need to be monitored within the first 6\u2005h of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An observational prospective cohort study of infants with gestational age \u226535 weeks, and above 1,800g, were included according to their arterial cord pH value (ApH): \u22647.00 vs. 7.01\u20137.10. Data was collected including obstetrical history, as well as neonatal comorbidities, including the presence of HIE, that happened within 6\u2005h of life. A standardized neurological exam was performed at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 9,537 births; 176 infants with ApH 7.01\u20137.10 and 117 infants with ApH \u22647.00. All 9 cases with moderate-to-severe HIE occurred among infants with ApH \u22647.00. The incidence of global and moderate-severe HIE was 3\/1,000 and 1\/1,000 births, respectively. Outcome at discharge (abnormal exam or death) showed an OR 12.03 (95% CI 1.53, 94.96) in infants with ApH \u22647.00 compared to ApH 7.01\u20137.10 cohort. Ventilation support was 5.1 times (95% CI 2.87, 9.03) more likely to be needed by those with cord ApH \u22647.00 compared to those with ApH 7.01\u20137.10, as well as hypoglycemia (37% vs. 25%; <jats:italic>p<\/jats:italic>\u2009=\u20090.026). In 55%, hypoglycemia occurred despite oral and\/or intravenous glucose administration had been already initiated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cord pH 7.00 might be a safe pH cut-off point when developing protocols to monitor infants born with acidemia in order to identify infants with moderate or severe HIE early on. There is non-negligible comorbidity in the ApH \u22647.00 cohort, but also in the 7.01\u20137.10 cohort.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1363576","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T05:08:55Z","timestamp":1711516135000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence of encephalopathy and comorbidity in infants with perinatal asphyxia: a comparative prospective cohort 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