{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:31:26Z","timestamp":1777483886248,"version":"3.51.4"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>In this study we combined non-invasive transcutaneous auricular vagal nerve stimulation (taVNS) with 40\u2005h of constraint induced movement therapy (CIMT) in infants. All infants completed the full intervention with no adverse events. Therapists were able to maintain high treatment fidelity and reported high ratings for ease of use and child tolerance. Preliminary results show promising gains on motor outcomes: Mean QUEST increase 19.17 (minimal clinically important difference, MCID 4.89); Mean GMFM increase 13.33 (MCID 1%\u20133%). Infants also exceeded expectations on Goal Attainment Scores (+1). Early data is promising that taVNS paired with intensive motor CIMT is feasible, reliable, and safe in young infants with hemiplegia, and may help harness activity-dependent plasticity to enhance functional movement.<\/jats:p>","DOI":"10.3389\/fped.2024.1365767","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:32:30Z","timestamp":1707798750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pairing taVNS and CIMT is feasible and may improve upper extremity function in infants"],"prefix":"10.3389","volume":"12","author":[{"given":"Kelly","family":"McGloon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Humanitzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Summers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashar W.","family":"Badran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne R.","family":"Cribb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Coker-Bolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4901014","DOI":"10.1155\/2016\/4901014","article-title":"Plasticity in the neonatal brain following hypoxic-ischaemic injury","volume":"2016","author":"Rocha-Ferreira","year":"2016","journal-title":"J Neural Transplant Plast"},{"key":"B2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jpeds.2011.08.069","article-title":"Elevated concentrations of inflammation-related proteins in postnatal blood predict severe developmental delay at two years in extremely premature infants","volume":"160","author":"O\u2019Shea","year":"2011","journal-title":"J Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.3174\/ajnr.A4312","article-title":"Tract-based spatial statistics in preterm-born neonates predicts cognitive and motor outcomes at 18 months","volume":"36","author":"Duerden","year":"2015","journal-title":"Am J Neuroradiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.siny.2006.02.003","article-title":"Inflammation, brain damage and visual dysfunction in preterm infants","volume":"11","author":"Dammann","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11910-020-1022-z","article-title":"State of the evidence traffic lights 2019: systematic review of interventions for preventing and treating children with cerebral palsy","volume":"20","author":"Novak","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"413","DOI":"10.5014\/ajot.2013.005959","article-title":"Systematic review of interventions used in occupational therapy to promote motor performance for children ages birth-5 years","volume":"67","author":"Case-Smith","year":"2013","journal-title":"Am J Occup Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/1440-1630.12666","article-title":"What is the threshold dose of upper limb training for children with cerebral palsy to improve function? 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