{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:49Z","timestamp":1753891909093,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neuroglial heterotopia is a rare lesion composed of differentiated neuroectodermal cells that manifest in extracranial locations, with the majority of cases predominantly occurring in the head and neck region. Retroperitoneal neuroglial heterotopia is exceptionally rare, with isolated cases published in the scientific literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>Here, we present the case of a 3-year-old girl who was admitted without clinical signs but presented with a palpable abdominal mass. Ultrasonography and computed tomography scans revealed a sizable cystic lesion within the retroperitoneal space. Subsequently, laparoscopic resection was performed. Histological examination unveiled neuroglial cell-lined cysts encompassing fibrous connective tissue, ganglia, glial tissue, and nerve bundles. Notably, distinct areas and cell types exhibited expression of S100, glial fibrillary acidic protein, and neuron-specific enolase. Follow-up assessments revealed no relapses or late complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In cases of retroperitoneal neuroglial heterotopia, most children may remain asymptomatic without any congenital anomalies. Despite their detectability through imaging, accurate preoperative diagnosis is seldom achieved. Generally, a favorable prognosis follows complete surgical resection, although further cases are required to confirm its long-term efficacy, necessitating extended follow-up for verification.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1369787","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:44:01Z","timestamp":1712551441000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Retroperitoneal neuroglial heterotopia: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Jianhua","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifa","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1097\/iop.0000000000000050","article-title":"Glial heterotopia or ectopic brain masquerading as a dacyrocystocele","volume":"31","author":"Ali","year":"2015","journal-title":"Ophthalmic Plastic Reconstr Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.14639\/0392-100x-n1977","article-title":"Nasal glial heterotopia: a systematic review of the literature and case report","volume":"42","author":"Gallego Compte","year":"2022","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"B3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.7874\/jao.2016.20.3.179","article-title":"Neuroglial choristoma of the middle ear with massive tympanosclerosis: a case report and literature review","volume":"20","author":"Shim","year":"2016","journal-title":"J Audiol Otol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/MPH.0b013e318215cef0","article-title":"Pulmonary glial heterotopia in a child diagnosed with Fanconi anemia and epilepsy","volume":"33","author":"Alonso","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1078\/0344-0338-00186","article-title":"Brain heterotopia in pharyngeal region. 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