{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:49Z","timestamp":1753891969636,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bladder profile in boys with Posterior Urethral Valves can be very varied with a spectrum going from high pressure, unstable, hypocompliant small bladders to hypercompliant, large acontractile bladders, with some being near-normal. Our question was whether appearance, specifically of the bladder, on initial VCUG was correlated to prenatal features and whether it could predict early postnatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We used a prospectively gathered database of boys with prenatally suspected PUV. We analyzed whether the appearance, specifically of the bladder, was related to date of prenatal diagnosis, presence of a megacystis on prenatal ultrasound, presence of vesico-ureteral reflux (VUR), presence of abnormal DMSA scan, nadir creatinine or presence of febrile urinary tract infection (fUTI) during the first two years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The database comprised 90 cystograms. 15% of bladders were judged normal\/regular, 54 % were small\/diverticular and 31% were large\/diverticular. Bladder appearance was not associated with presence of prenatal megacystis, abnormal DMSA scan, VUR, nor rate of fUTI. The only significant associations were normal\/regular bladder and early prenatal diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and normal\/regular bladder and elevated nadir creatinine (&amp;gt;75\u00b5mol\/l) (<jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We believe that when focusing solely on the appearance of the bladder, excluding information about the urethra and presence of reflux, the cystogram alone is insufficient to inform on future bladder function. This could be used as an argument in favor of performing early urodynamics in this population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1380502","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T04:56:31Z","timestamp":1713416191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Appearance of the bladder on initial voiding cystogram in boys with PUV and its relation to pre and postnatal findings"],"prefix":"10.3389","volume":"12","author":[{"given":"S.","family":"Pecorelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ferdynus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1053\/jarr.2001.26348","article-title":"Congenital obstructive uropathy: its origin and contribution to end-stage renal disease in children","volume":"8","author":"Woolf","year":"2001","journal-title":"Adv Ren Replace Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1464-410x.1988.tb04267.x","article-title":"Long-term outcome of boys with posterior urethral valves","volume":"62","author":"Parkhouse","year":"1988","journal-title":"Br J Urol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"186.e1","DOI":"10.1016\/j.jpurol.2022.01.017","article-title":"Nadir creatinine predicts long-term bladder function in boys with posterior urethral valves","volume":"18","author":"Delefortrie","year":"2022","journal-title":"J Pediatr Urol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1046\/j.1464-410x.2000.00700.x","article-title":"The changing urodynamic pattern from infancy to adolescence in boys with posterior urethral valves","volume":"85","author":"De Gennaro","year":"2000","journal-title":"BJU Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1148\/rg.241035027","article-title":"Detection of fetal structural abnormalities with US during early pregnancy","volume":"24","author":"Fong","year":"2004","journal-title":"Radiographics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s00247-007-0695-7","article-title":"Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007","volume":"38","author":"Riccabona","year":"2008","journal-title":"Pediatr Radiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jpurol.2016.11.001","article-title":"Establishing a standard protocol for the voiding cystourethrography","volume":"12","author":"Frimberger","year":"2016","journal-title":"J Pediatr Urol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00345-020-03175-2","article-title":"Is there a need for endoscopic evaluation in symptomatic boys with an unsuspicious urethra on VCUG? A consideration of secondary radiologic signs of posterior urethral valves","volume":"39","author":"Haid","year":"2021","journal-title":"World J Urol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1007\/s00330-023-10126-z","article-title":"Indirect signs of infravesical obstruction on voiding cystourethrography improve post-neonatal posterior urethral valves detection rate","volume":"34","author":"Marzuillo","year":"2024","journal-title":"Eur Radiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"839.e1","DOI":"10.1016\/j.jpurol.2020.09.015","article-title":"A simple screening tool for an unfavorable bladder in children with myelomeningocele: is the height to width ratio of the cystogram useful to predict high-pressure bladder?","volume":"16","author":"Kumano","year":"2020","journal-title":"J Pediatr Urol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00383-022-05121-2","article-title":"Bladder height width ratio on voiding cystourethrogram as a predictor of future valve bladder in children with posterior urethral valve","volume":"38","author":"Babu","year":"2022","journal-title":"Pediatr Surg Int"},{"key":"B12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.jpurol.2022.06.002","article-title":"Posterior urethral morphology on initial voiding cystourethrogram correlates to early renal outcomes in infants with posterior urethral valves","volume":"18","author":"Wu","year":"2022","journal-title":"J Pediatr Urol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"265.e1","DOI":"10.1016\/j.jpurol.2016.12.005","article-title":"Cystometrogram appearance in PUV is reliably quantified by the shape, wall, reflux and diverticuli (SWRD) score, and presages the need for intervention","volume":"13","author":"Niyogi","year":"2017","journal-title":"J Pediatr Urol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"427.e1","DOI":"10.1016\/j.jpurol.2023.03.040","article-title":"Surrogate imaging markers of urodynamic proven bladder dysfunction in posterior urethral valves: a comprehensive evaluation","volume":"19","author":"Archana","year":"2023","journal-title":"J Pediatr Urol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1007\/s00247-016-3634-7","article-title":"Posterior urethral valves: are neonatal imaging findings predictive of renal function during early childhood?","volume":"46","author":"Hochart","year":"2016","journal-title":"Pediatr Radiol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1380502\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T04:56:34Z","timestamp":1713416194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1380502\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":15,"alternative-id":["10.3389\/fped.2024.1380502"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1380502","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"article-number":"1380502"}}