{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:46:47Z","timestamp":1784771207744,"version":"3.55.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Aim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>This was a post-hoc analysis of secondary outcome parameters of a prospective observational study including preterm neonates with and term neonates without respiratory support. Non-asphyxiated neonates with cerebral oxygenation measured with near-infrared spectroscopy during the first 15\u2005min and with blood gas analyses from arterial umbilical cord blood were included. Arterial oxygen saturation (SpO<jats:sub>2<\/jats:sub>) and heart rate (HR) were monitored with pulse oximetry. Potential correlations were investigated between acid-base and metabolic parameters (pH-value, bicarbonate, base-excess, and lactate) and crSO<jats:sub>2<\/jats:sub>\/cFTOE 5\u2005min after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy-seven neonates were included: 14 preterm neonates with respiratory support (mean gestational age [GA] 31.4\u2009\u00b1\u20094.1 weeks; mean birth weight [BW] 1,690\u2009\u00b1\u2009640\u2005g) and 63 term neonates without respiratory support (GA 38.7\u2009\u00b1\u20090.8 weeks; BW 3,258\u2009\u00b1\u2009443\u2005g). Mean crSO<jats:sub>2<\/jats:sub> 5\u2005min after birth was 44.0%\u2009\u00b1\u200924.2% in preterm and 62.2%\u2009\u00b1\u200920.01% in term neonates. Mean cFTOE 5\u2005min after birth was 0.46\u2009\u00b1\u20090.06 in preterm and 0.27\u2009\u00b1\u20090.19 in term neonates. In preterm neonates with respiratory support higher lactate was significantly associated with lower crSO<jats:sub>2<\/jats:sub> and SpO<jats:sub>2<\/jats:sub> and tended to be associated with higher cFTOE. In term neonates without respiratory support no significant correlations were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In non-asphyxiated preterm neonates with respiratory support, lactate levels were negatively associated with crSO<jats:sub>2<\/jats:sub> and SpO<jats:sub>2<\/jats:sub>, whereas in term neonates without respiratory support no associations were observed.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1385726","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:56:16Z","timestamp":1711601776000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth"],"prefix":"10.3389","volume":"12","author":[{"given":"Martin","family":"Dusleag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berndt","family":"Urlesberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schwaberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariae","family":"Baik-Schneditz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schlatzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina H.","family":"Wolfsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1146\/annurev.ph.41.030179.002123","article-title":"Fetal and neonatal pulmonary circulation","volume":"41","author":"Rudolph","year":"1979","journal-title":"Annu Rev Physiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1213\/ANE.0b013e31829bdc5c","article-title":"A proposal for a new method of evaluation of the newborn infant","volume":"32","author":"Apgar","year":"1953","journal-title":"Curr Res Anesth Analg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fped.2017.00029","article-title":"Cerebral tissue oxygenation during immediate neonatal transition and resuscitation","volume":"5","author":"Pichler","year":"2017","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.resuscitation.2015.07.029","article-title":"European resuscitation council guidelines for resuscitation 2015: section 7. 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