{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:41:46Z","timestamp":1790862106327,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the epidemiological and clinical characteristics of children with <jats:italic>Mycoplasma pneumoniae<\/jats:italic> pneumonia (MPP) in Hubei, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed inpatients with MPP from 20 hospitals in Hubei, China from January 2021 to December 2022. The co-detected pathogens of <jats:italic>Mycoplasma pneumoniae<\/jats:italic> (<jats:italic>M. pneumoniae<\/jats:italic>) were investigated using targeted next-generation sequencing (tNGS), and 23S rRNA gene mutations were analyzed to assess the macrolide resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>M. pneumoniae<\/jats:italic> infected 20.7% of patients with CAP, with cough (96.59%) and fever (80.28%) being the most prevalent symptoms. The infection rates in children younger than 1, 1\u20132, 3\u20136, 7\u201312, and older than 12\u2005years were 6.17%, 19.98%, 26.97%, 43.93%, and 2.95%, respectively. Among 1,349 patients undergoing tNGS, the overall co-detection rate was 59.45%, with <jats:italic>Streptococcus pneumoniae<\/jats:italic> (29.30%), <jats:italic>Haemophilus influenzae<\/jats:italic> (23.57%), and <jats:italic>Human rhinovirus<\/jats:italic> (17.21%) being the most commonly co-detected pathogens. In 635 patients undergoing the 23S rRNA gene mutation test, 86.30% exhibited positive mutations (A2063G, 98.00%; A2064G, 1.50%; A2067G, 0.50%). Despite a significant age difference (<jats:italic>P<\/jats:italic>\u2009=\u20090.037) between macrolide-resistant <jats:italic>M. pneumoniae<\/jats:italic> and macrolide-sensitive <jats:italic>M. pneumoniae<\/jats:italic> groups, there were no significant differences in symptoms, lab data, or disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Hubei Province, the prevalence of exhibited consistent changes during the COVID-19 pandemic. MPP was prevalent year-round, particularly in summer and autumn, with school-age children being more susceptible. Co-detections of viruses and bacteria were frequent in MPP cases, and macrolide resistance exceeded 85%. Ongoing surveillance of <jats:italic>M. pneumoniae<\/jats:italic> in children is crucial for understanding the healthcare impact of MPP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1388132","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T04:27:56Z","timestamp":1729830476000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of the COVID-19 pandemic on epidemiological and clinical characteristics of Mycoplasma pneumoniae pneumonia in children: a multicenter study from Hubei, 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