{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:27Z","timestamp":1753891947756,"version":"3.41.2"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Urinary tract infections (UTIs) associated with indwelling urinary catheterization (IUC) in premature newborns (PNBs) pose a significant challenge in neonatal intensive care units (NICUs) due to the vulnerability of this population to infections and the necessity of invasive procedures. While bacterial UTIs have historically been predominant, there is a rising incidence of fungal pathogens, particularly non-<jats:italic>albicans Candida<\/jats:italic> strains like <jats:italic>Candida glabrata<\/jats:italic> and <jats:italic>Candida tropicalis<\/jats:italic>, attributed to broad-spectrum antibiotic use. Diagnosis of fungal UTIs in a PNB relies on culturing <jats:italic>Candida<\/jats:italic> spp. from properly collected urine samples, particularly critical in very low birth weight (VLBW) PNBs because of the risk of invasive candidiasis and associated complications. We present a case of an extremely premature newborn (EPNB) successfully treated for a UTI caused by <jats:italic>C. glabrata<\/jats:italic> with micafungin. Our case exhibits micafungin as a potentially safe and effective alternative for treating <jats:italic>C. glabrata<\/jats:italic> UTIs in neonates.<\/jats:p>","DOI":"10.3389\/fped.2024.1397456","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:32:31Z","timestamp":1715920351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Micafungin for treating Candida glabrata urinary infection: a clinical case in a premature neonate"],"prefix":"10.3389","volume":"12","author":[{"given":"Carlos Javier","family":"Parramon-Teixido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Garcia Esquerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Antoinette","family":"Frick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Tripodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gomez-Ganda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar Wenceslao","family":"Ruiz-Campillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Josep","family":"Caba\u00f1as-Poy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1053\/j.semperi.2012.06.006","article-title":"Health care\u2013associated infections in the neonatal intensive care unit: barriers to continued success","volume":"36","author":"Bizzarro","year":"2012","journal-title":"Semin Perinatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/tropej\/fmq104","article-title":"Study of nosocomial urinary tract infections in a pediatric intensive care unit","volume":"57","author":"Brindha","year":"2011","journal-title":"J Trop Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e15033","DOI":"10.1111\/ped.15033","article-title":"Treatment of Candida urinary tract infections with micafungin in children","volume":"64","author":"Ekinci","year":"2022","journal-title":"Pediatr Int"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"article-title":"Infecci\u00f3n urinaria en el reci\u00e9n nacido. 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