{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:45:40Z","timestamp":1757781940862,"version":"3.41.2"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Hematologic malignancies are a well-known risk factor for cardiovascular disease development. Chemotherapeutic protocols commonly include intensive fluid therapy (IFT), which may negatively influence the cardiovascular system and predispose to arterial hypertension. This study aims to evaluate atrial natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and changes in blood pressure in children with hematological malignancies undergoing intensive fluid therapy. This prospective cohort study comprised thirteen children. 24-h ambulatory blood pressure monitoring (ABPM) and concentrations of NT-proBNP and hs-TnT were performed on the first day of IFT and during follow-up. There were no statistically significant differences in 24-h, daytime, night-time systolic (SBP) and diastolic blood pressure (DBP), SBP and DBP dipping, and the number of non-dippers during intensive fluid therapy compared to the control points. The mean NT-proBNP concentration at 24\u2005h was 321.27\u2009\u00b1\u2009318.08\u2005pg\/mL and was significantly higher compared with baseline (79.13\u2009\u00b1\u2009105.42\u2005pg\/mL) and follow-up (175.92\u2009\u00b1\u2009241.48\u2005pg\/mL); <jats:italic>p<\/jats:italic>-values 0.005 and <jats:italic>p<\/jats:italic>\u2009=\u20090.006 respectively. Troponin T concentration at 24\u2005h was not significantly different compared with baseline and follow-up. These results show no significant influence of intensive fluid therapy on blood pressure profile. In contrast, an increase in NT-proBNP values 24\u2005h after the start of fluid therapy may reflect the impact of fluid overload on the cardiovascular system.<\/jats:p>","DOI":"10.3389\/fped.2024.1408231","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:27:06Z","timestamp":1732681626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["High NT pro-BNP levels in children with malignant disorder receiving intensive fluid treatment: a prospective comparative study"],"prefix":"10.3389","volume":"12","author":[{"given":"Weronika","family":"Pawlik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Strzemecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Stachura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kr\u00f3lak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Ociepa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1161\/HYP.0000000000000224","article-title":"Cancer therapy-related hypertension: a scientific statement from the American Heart Association","volume":"80","author":"Cohen","year":"2023","journal-title":"Hypertension"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/FPHAR.2021.712995","article-title":"Hypertension induced by combination therapy of cancer: a systematic review and meta-analysis of global clinical trials","volume":"12","author":"Guo","year":"2021","journal-title":"Front Pharmacol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2165\/00002018-200225050-00001","article-title":"Predicting cancer therapy-induced cardiotoxicity: the role of troponins and other markers","volume":"25","author":"Sparano","year":"2002","journal-title":"Drug Saf"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08880018.2018.1425784","article-title":"Prevalence of hypertension determined by ambulatory blood pressure monitoring (ABPM) and body composition in long-term survivors of childhood cancer","volume":"35","author":"Guler","year":"2018","journal-title":"Pediatr Hematol Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41598-021-94127-2","article-title":"Arterial hypertension assessment in a population with chronic myeloid leukemia","volume":"11","author":"Roa-Chamorro","year":"2021","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1155\/2021\/8828410","article-title":"Cardiotoxicity: a major setback in childhood leukemia treatment","volume":"2021","author":"Laza\u030cr","year":"2021","journal-title":"Dis Markers"},{"key":"B7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-3-030-43032-0_15","article-title":"Anthracycline-induced cardiotoxicity: causes, mechanisms, and prevention","volume":"1257","author":"Bhagat","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.blre.2019.03.003","article-title":"Hypertension in hematologic malignancies and hematopoietic cell transplantation: an emerging issue with the introduction of novel treatments","volume":"35","author":"Gavriilaki","year":"2019","journal-title":"Blood Rev"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IBPC.S242244","article-title":"Hypertension in pediatric acute lymphoblastic leukemia patients: prevalence, impact, and management strategies","volume":"15","author":"Murphy","year":"2022","journal-title":"Integr Blood Press Control"},{"key":"B10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/MPH.0000000000001349","article-title":"Prevalence and risk factors for arterial hypertension development in childhood acute lymphoblastic leukemia survivors","volume":"41","author":"Ociepa","year":"2019","journal-title":"J Pediatr Hematol Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00417-012-1940-9","article-title":"Harrisons\u2019s principles of internal medicine, 18th edition, two volumes and DVD. Eds: Dan L. Longo, Anthony S. Fauci, dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson and Joseph Loscalzo, ISBN-13: 9780071748896 McGraw Hill","volume":"250","author":"Masters","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1042\/CS20220500","article-title":"Revisiting blood pressure and body fluid status","volume":"137","author":"Kitada","year":"2023","journal-title":"Clin Sci (Lond)"},{"volume-title":"Acute Leukemias Edited by New Directions for Clinical Research","year":"2003","author":"Pui","key":"B13"},{"volume-title":"Pediatric Haematology\/Oncology Ward Officer\u2019s Handbook","year":"2015","key":"B14"},{"key":"B15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.clnesp.2018.08.022","article-title":"Association of hyperhydration evaluated by bioelectrical impedance analysis and mortality in patients with different medical conditions: systematic review and meta-analyses","volume":"28","author":"da Silva","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1002\/cncr.32196","article-title":"Unrecognized fluid overload during induction therapy increases morbidity in patients with acute promyelocytic leukemia","volume":"125","author":"Chamoun","year":"2019","journal-title":"Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1001\/jamapediatrics.2017.4540","article-title":"Association between fluid balance and outcomes in critically ill children: a systematic review and meta-analysis","volume":"172","author":"Alobaidi","year":"2018","journal-title":"JAMA Pediatr"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e27975","DOI":"10.1002\/pbc.27975","article-title":"Impact of fluid overload and infection on respiratory adverse event development during induction therapy for childhood acute myeloid leukemia","volume":"66","author":"Miller","year":"2019","journal-title":"Pediatr Blood Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1681\/ASN.2016121341","article-title":"Chronic fluid overload and mortality in ESRD","volume":"28","author":"Zoccali","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1093\/ndt\/gfr678","article-title":"Importance of normohydration for the long-term survival of haemodialysis patients","volume":"27","author":"Chazot","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"B21","first-page":"3593","article-title":"Whole-body and thoracic bioimpedance measurement: hypertension and hyperhydration in hemodialyisis patients","author":"Nescolarde","year":"2007"},{"key":"B22","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00467-011-2060-1","article-title":"Association between left ventricular mass index and cardiac function in pediatric dialysis patients","volume":"27","author":"Shamszad","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/j.1525-1594.2011.01401.x","article-title":"Blood pressure measurements and left ventricular mass Index in hemodialysis patients","volume":"36","author":"Ekart","year":"2012","journal-title":"Artif Organs"},{"key":"B24","first-page":"1","article-title":"Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients","volume":"13","author":"Lane","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"B25","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/ckj\/sfu093","article-title":"Methotrexate toxicity treated with continuous venovenous hemofiltration, leucovorin and glucarpidase","volume":"7","author":"Connors","year":"2014","journal-title":"Clin Kidney J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s12185-021-03132-8","article-title":"Risk factors for high-dose methotrexate-induced nephrotoxicity","volume":"114","author":"Kawaguchi","year":"2021","journal-title":"Int J Hematol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1097\/MPH.0b013e31814d6777","article-title":"Retrospective study on elimination delay of methotrexate in high-dose therapy of childhood acute lymphoblastic leukemia in China","volume":"29","author":"Xu","year":"2007","journal-title":"J Pediatr Hematol Oncol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/01.CIR.0000160923.04524.5B","article-title":"Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: follow-up results from the pressioni arteriose monitorate e loro associazioni (PAMELA) study","volume":"111","author":"Sega","year":"2005","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1097\/HJH.0b013e328363e964","article-title":"European society of hypertension position paper on ambulatory blood pressure monitoring","volume":"31","author":"O\u2019Brien","year":"2013","journal-title":"J Hypertens"},{"key":"B30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/MBP.0000000000000299","article-title":"Office blood pressure measurement alone often misclassifies treatment status in children with primary hypertension","volume":"22","author":"Samuel","year":"2017","journal-title":"Blood Press Monit"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1155\/2016\/7816830","article-title":"Can ambulatory blood pressure variability contribute to individual cardiovascular risk stratification?","volume":"2016","author":"Magd\u00e1s","year":"2016","journal-title":"Comput Math Methods Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1097\/HJH.0b013e328361e4a6","article-title":"Increased short-term blood pressure variability is associated with early left ventricular systolic dysfunction in newly diagnosed untreated hypertensive patients","volume":"31","author":"Tatasciore","year":"2013","journal-title":"J Hypertens"},{"key":"B33","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/HYPERTENSIONAHA.107.090084","article-title":"Awake systolic blood pressure variability correlates with target-organ damage in hypertensive subjects","volume":"50","author":"Tatasciore","year":"2007","journal-title":"Hypertension"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1097\/HJH.0b013e328330a94f","article-title":"Time rate of blood pressure variation is associated with impaired renal function in hypertensive patients","volume":"27","author":"Manios","year":"2009","journal-title":"J Hypertens"},{"key":"B35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/1471-2369-14-266","article-title":"Fluid overload in hemodialysis patients: a cross-sectional study to determine its association with cardiac biomarkers and nutritional status","volume":"14","author":"Antlanger","year":"2013","journal-title":"BMC Nephrol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e142","DOI":"10.1097\/MJT.0000000000000930","article-title":"Elevations in high-sensitive cardiac troponin T and N-terminal prohormone brain natriuretic peptide levels in the Serum can predict the development of anthracycline-induced cardiomyopathy","volume":"27","author":"Bisoc","year":"2020","journal-title":"Am J Ther"},{"key":"B37","first-page":"122","article-title":"The role of biomarkers and echocardiography in the evaluation of cardiotoxicity risk in children treated for leukemia","volume":"23","author":"Cainap","year":"2018","journal-title":"JBUON"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.2215\/CJN.09001209","article-title":"N-terminal proBNP\u2014marker of cardiac dysfunction, fluid overload, or malnutrition in hemodialysis patients?","volume":"5","author":"Booth","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1365-2362.2007.01785.x","article-title":"Cardiac biomarkers and survival in haemodialysis patients","volume":"37","author":"Sommerer","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"B40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/ndt\/gfp417","article-title":"Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study","volume":"25","author":"Jacobs","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"B41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1751-7133.2011.00258.x","article-title":"Exaggerated NT-proBNP production in patients with hematologic malignancies: a case series","volume":"18","author":"Andreu","year":"2012","journal-title":"Congest Heart Fail"},{"key":"B42","doi-asserted-by":"publisher","first-page":"186","DOI":"10.5603\/AH.a2017.0023","article-title":"Effect of hydration status and variability of blood pressure and heart rate induced by hemodialysis on intradialytic changes of high sensitive troponin T","volume":"21","author":"Wajdlich","year":"2017","journal-title":"Arter Hypertens"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1161\/01.CIR.96.8.2641","article-title":"Predictive value of cardiac troponin T in pediatric patients at risk for myocardial injury","volume":"96","author":"Lipshultz","year":"1997","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1371\/JOURNAL.PONE.0077063","article-title":"Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function","volume":"8","author":"Cheung","year":"2013","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1756-9966-31-86","article-title":"Role of NT-proBNP in detection of myocardial damage in childhood leukemia survivors treated with and without anthracyclines","volume":"31","author":"Mladosievicova","year":"2012","journal-title":"J Exp Clin Cancer Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00246-022-02827-x","article-title":"Age-dependent reference values for hstroponin T and NT-proBNP and determining factors in a cohort of healthy children (the LIFE child study)","volume":"43","author":"Kiess","year":"2022","journal-title":"Pediatr Cardiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1097\/00004872-200210000-00019","article-title":"Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions","volume":"20","author":"W\u00fchl","year":"2002","journal-title":"J Hypertens"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1002\/sim.4780111005","article-title":"Smoothing reference centile curves: the LMS method and penalized likelihood","volume":"11","author":"Cole","year":"1992","journal-title":"Stat Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"E114","DOI":"10.1161\/HYP.0000000000000215","article-title":"Ambulatory blood pressure monitoring in children and adolescents: 2022 update: a scientific statement from the American Heart Association","volume":"79","author":"Flynn","year":"2022","journal-title":"Hypertension"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1200\/JCO.2008.21.1425","article-title":"Late mortality among 5-year survivors of childhood cancer: a summary from the childhood cancer survivor study","volume":"27","author":"Armstrong","year":"2009","journal-title":"J Clin Oncol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1161\/CIR.0b013e3182a88099","article-title":"Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions","volume":"128","author":"Lipshultz","year":"2013","journal-title":"Circulation"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5493","DOI":"10.26355\/EURREV_202306_32786","article-title":"Chronic myeloid leukemia, tyrosine kinase inhibitors and cardiovascular system","volume":"27","author":"Malkan","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ijcard.2016.11.025","article-title":"Endothelial dysfunction and cardiovascular risk factors in childhood acute lymphoblastic leukemia survivors","volume":"228","author":"Giordano","year":"2017","journal-title":"Int J Cardiol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00432-017-2560-x","article-title":"Cardiovascular effects of Hodgkin\u2019s lymphoma: a review of literature","volume":"144","author":"Jacob","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1016\/j.ejca.2014.06.023","article-title":"Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia","volume":"50","author":"Bhojwani","year":"2014","journal-title":"Eur J Cancer"},{"key":"B56","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/pan.14512","article-title":"Fluid bolus administration in children, who responds and how? A systematic review and meta-analysis","volume":"32","author":"Loomba","year":"2022","journal-title":"Paediatr Anaesth"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jpeds.2022.10.029","article-title":"Long-term kidney and cardiovascular complications in pediatric cancer survivors","volume":"255","author":"Hsiao","year":"2023","journal-title":"J Pediatr"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e29628","DOI":"10.1002\/pbc.29628","article-title":"Extent of hypertension and renal injury in children surviving acute lymphoblastic leukemia","volume":"69","author":"Kumar","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"B60","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000526902","article-title":"Diagnosis of fluid overload: from conventional to contemporary concepts","volume":"12","author":"Koratala","year":"2022","journal-title":"Cardiorenal Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/ajh.26805","article-title":"N-terminal pro-brain natriuretic peptide is a prognostic marker for response to intensive chemotherapy, early death, and overall survival in acute myeloid leukemia","volume":"98","author":"Graf","year":"2023","journal-title":"Am J Hematol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.leukres.2011.01.018","article-title":"NT-proBNP: a cardiac biomarker to assess prognosis in non-Hodgkin lymphoma","volume":"35","author":"Gimeno","year":"2011","journal-title":"Leuk Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3324\/haematol.2016.153791","article-title":"Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe","volume":"102","author":"Maitra","year":"2017","journal-title":"Haematologica"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1158\/1055-9965.EPI-09-1237","article-title":"Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European prospective investigation into cancer and nutrition","volume":"19","author":"Hosnijeh","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1200\/JCO.2010.30.3404","article-title":"Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes","volume":"30","author":"Lipshultz","year":"2012","journal-title":"J Clin Oncol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1408231\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:27:12Z","timestamp":1732681632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1408231\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":65,"alternative-id":["10.3389\/fped.2024.1408231"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1408231","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"article-number":"1408231"}}