{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:30:09Z","timestamp":1784860209266,"version":"3.55.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["IP-2020-02-7166"],"award-info":[{"award-number":["IP-2020-02-7166"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether variation of regional cerebral oxygen saturation (rScO<jats:sub>2<\/jats:sub>) within three days after delivery predicts development of brain injury (intraventricular\/cerebellar hemorrhage or white matter injury) in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>A prospective study of neonates &amp;lt;32 weeks gestational age with normal cranial ultrasound admitted between 2018 and 2022. All received rScO<jats:sub>2<\/jats:sub> monitoring with near-infrared spectroscopy at admission up to 72\u2005h of life. To assess brain injury a magnetic resonance imaging was performed at term-equivalent age. We assessed the association between rScO<jats:sub>2<\/jats:sub> variability (short-term average real variability, rScO<jats:sub>2ARV<\/jats:sub>, and standard deviation, rScO<jats:sub>2SD<\/jats:sub>), mean rScO<jats:sub>2<\/jats:sub> (rScO<jats:sub>2MEAN<\/jats:sub>), and percentage of time rScO<jats:sub>2<\/jats:sub> spent below 60% (rScO<jats:sub>2TIME&amp;lt;60%<\/jats:sub>) during the first 72\u2005h of life and brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median [IQR] time from birth to brain imaging was 68 [59-79] days. Of 81 neonates, 49 had some form of brain injury. Compared to neonates without injury, in those with injury rScO<jats:sub>2ARV<\/jats:sub> was higher during the first 24\u2005h (<jats:italic>P\u2009<\/jats:italic>=\u20090.026); rScO<jats:sub>2SD<\/jats:sub> was higher at 24 and 72\u2005h (<jats:italic>P\u2009<\/jats:italic>=\u20090.029 and <jats:italic>P\u2009<\/jats:italic>=\u20090.030, respectively), rScO<jats:sub>2MEAN<\/jats:sub> was lower at 48\u2005h (<jats:italic>P\u2009<\/jats:italic>=\u20090.042), and rScO<jats:sub>2TIME&amp;lt;60%<\/jats:sub> was longer at 24, 48, and 72\u2005h (<jats:italic>P\u2009<\/jats:italic>=\u20090.050, <jats:italic>P\u2009<\/jats:italic>=\u20090.041, and <jats:italic>P\u2009<\/jats:italic>=\u20090.009, respectively). Similar results were observed in multivariable logistic regression. Although not all results were statistically significant, increased rScO<jats:sub>2<\/jats:sub> variability (rScO<jats:sub>2ARV<\/jats:sub> and rScO<jats:sub>2SD<\/jats:sub>) and lower mean values of rScO2 were associated with increased likelihood of brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In preterm infants increased aberration of rScO<jats:sub>2<\/jats:sub> in early postdelivery period was associated with an increased likelihood of brain injury diagnosis at term-equivalent age.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1426874","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T04:43:15Z","timestamp":1721623395000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Regional cerebral oxygen saturation variability and brain injury in preterm infants"],"prefix":"10.3389","volume":"12","author":[{"given":"Tomislav","family":"\u0106aleta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Ryll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Bojani\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada Sindi\u010di\u0107","family":"Dessardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell R.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Sprung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Rado\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Kostovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u017ea","family":"Grizelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"683138","DOI":"10.3389\/fped.2021.683138","article-title":"\u201cThe first thousand days\u201d define a fetal\/neonatal neurology program","volume":"9","author":"Scher","year":"2021","journal-title":"Front Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1321674","DOI":"10.3389\/fneur.2023.1321674","article-title":"Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice","volume":"14","author":"Scher","year":"2024","journal-title":"Front Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e368","DOI":"10.5001\/omj.2022.41","article-title":"Late-onset sepsis in preterm neonates is associated with higher risks of cerebellar hemorrhage and lower motor scores at three years of age","volume":"37","author":"Kartam","year":"2022","journal-title":"Oman Med J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"151694","DOI":"10.1016\/j.semperi.2022.151694","article-title":"Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: the gut-brain axis","volume":"47","author":"Lu","year":"2023","journal-title":"Semin. 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