{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:28:57Z","timestamp":1789604937892,"version":"build-2803163510"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the effectiveness of intranasal dexmedetomidine in reducing pain scores during retinopathy of prematurity (ROP) screening examinations in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants born at \u226432 weeks of gestational age, undergoing routine ROP examinations in the neonatal intensive care unit, were included in the study and divided into two groups: the standard protocol group (<jats:italic>n<\/jats:italic>\u2009=\u200943) and the dexmedetomidine group (<jats:italic>n<\/jats:italic>\u2009=\u200956), over a 1-year period. Both groups received standard procedural preparation including swaddling, oral dextrose, and topical anesthesia with proparacaine. The dexmedetomidine group additionally received intranasal dexmedetomidine at a dose of 1\u2005mcg\/kg before the procedure. Pain scores (PIPP score), heart rate, respiratory rate, blood pressure, and oxygen saturation were compared at baseline, 1-min, and 5-min during the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between the groups regarding descriptive and pre-procedure characteristics. In the dexmedetomidine group, the median (25-75p) PIPP score, heart rate, systolic blood pressure and mean (\u00b1SD) respiratory rate measured at the 1st minute of the procedure were significantly lower than those in the standard group [PIPP score 10 (8\u201313) vs. 14 (10\u201316), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001; heart rate 165 (153\u2013176) beats\/min vs. 182 (17\u2013190) beats\/min, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001; respiratory rate 60 (\u00b17) breaths\/min vs. 65(\u00b19) breaths\/min, <jats:italic>p<\/jats:italic>\u2009=\u20090.002; systolic blood pressure 78 (70\u201392) mmHg vs. 87 (78\u201396) mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.024; respectively] whereas the saturation value was significantly higher (88% (81\u201395) vs. 84% (70\u201392), <jats:italic>p<\/jats:italic>\u2009=\u20090.036; respectively). By the 5th minute of the procedure, the median (25-75p) PIPP score [4 (2\u20136) vs. 6 (4\u201310), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001], heart rate [148 (143\u2013166) beats\/min vs. 162 (152\u2013180) beats\/min, <jats:italic>p<\/jats:italic>\u2009=\u20090.001] and respiratory rate [56 (54\u201358) breaths\/min vs. 58 (54\u201362) breaths\/min, <jats:italic>p<\/jats:italic>\u2009=\u20090.034] were significantly lower, and the saturation level was significantly higher [96% (94\u201397) vs. 93% (91\u201396), <jats:italic>p<\/jats:italic>\u2009=\u20090.003] in the dexmedetomidine group. Additionally, the frequency of adverse effects was significantly lower in the dexmedetomidine group compared to the standard protocol group (11% vs. 47%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administering intranasal dexmedetomidine before ROP screening examinations was associated with a decrease in pain scores among preterm infants. This suggests its potential as an effective and well-tolerated method for pain management during ROP screenings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1441324","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T04:58:32Z","timestamp":1722574712000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Intranasal dexmedetomidine reduces pain scores in preterm infants during retinopathy of prematurity screening"],"prefix":"10.3389","volume":"12","author":[{"given":"Nurten","family":"Ozkan 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