{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T17:34:58Z","timestamp":1782581698541,"version":"3.54.5"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Mid-trimester preterm premature rupture of membranes is a rare complication of pregnancy associated with significant maternal and fetal risks. The ensuing prolonged oligohydramnios can lead to fetal pulmonary hypoplasia. In addition, there is an increased risk of miscarriage, preterm birth, and chorioamnionitis, contributing to septic morbidity in the mother\u2013baby dyad. This case report describes the management and outcomes of an infant born at 32\u2005weeks following the rupture of membranes at 16\u2005weeks of gestation, resulting in severe oligohydramnios. Soon after birth, the infant had respiratory compromise, requiring high-frequency oscillatory ventilation and nitric oxide. Despite the initial poor prognosis, the infant remained stable with various ventilation modalities managed by a multidisciplinary team. He was discharged home after 108\u2005days in the hospital and remained on non-invasive ventilatory support until 8\u2005months of age while the home care and hospital specialty teams monitored him. The favorable respiratory outcome of this case is a rarity for cases with similar clinical circumstances, in which the managing team counsels parents about poor fetal outcomes and many proceed to terminate the pregnancies. In this reported case, we highlight the importance of multidisciplinary and interprofessional team management from antepartum monitoring and planning delivery time to subsequent short- and long-term postnatal care involving maternal-fetal medicine specialists, neonatologists, pediatric cardiology and respiratory specialists, and home care teams.<\/jats:p>","DOI":"10.3389\/fped.2024.1457129","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T14:39:39Z","timestamp":1736951979000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Respiratory outcome in a preterm infant following previable rupture of membranes and persistent oligohydramnios"],"prefix":"10.3389","volume":"12","author":[{"given":"Akila","family":"Subramanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ong Kai","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Pugalenthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Samuel","family":"Rajadurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay Kok","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ajog.2009.06.049","article-title":"The management of preterm premature rupture of the membranes near the limit of fetal viability","volume":"201","author":"Waters","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.placenta.2006.11.009","article-title":"Amniotic fluid water dynamics","volume":"28","author":"Beall","year":"2007","journal-title":"Placenta"},{"key":"B3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s12011-015-0557-3","article-title":"Concentrations of mineral in amniotic fluid and their relations to selected maternal and fetal parameters","volume":"172","author":"Suliburska","year":"2016","journal-title":"Biol Trace Elem Res"},{"key":"B4","first-page":"649","article-title":"Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung","volume":"123","author":"Alcorn","year":"1977","journal-title":"J Anat"},{"key":"B5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/0002-9378(92)91378-N","article-title":"Mimicking low amniotic pressure by chronic pharyngeal drainage does not impair lung development in the sheep","volume":"166","author":"Fisk","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1113\/jphysiol.1983.sp014729","article-title":"Upper airway dynamics during breathing and during apnoea in fetal lambs","volume":"339","author":"Fewell","year":"1983","journal-title":"J Physiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1113\/jphysiol.1983.sp014929","article-title":"Effects of Adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb","volume":"344","author":"Brown","year":"1983","journal-title":"J Physiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1152\/jappl.1996.81.1.209","article-title":"Regulation of lung expansion and lung growth before birth","volume":"81","author":"Harding","year":"1996","journal-title":"J Appl Physiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1172\/JCI114834","article-title":"Role of lung fluid volume in growth and maturation of the fetal sheep lung","volume":"86","author":"Moessinger","year":"1990","journal-title":"J Clin Invest"},{"key":"B10","first-page":"173","article-title":"Main pulmonary artery ligation reduces lung fluid production in fetal sheep","volume":"16","author":"Wallen","year":"1991","journal-title":"J Dev Physiol"},{"key":"B11","first-page":"260","article-title":"Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth survival at birth","volume":"88","author":"Harrison","year":"1980","journal-title":"Surgery"},{"key":"B12","first-page":"419","article-title":"The effect of prolonged oligohydramnios on fetal lung development, maturation and ventilatory patterns in the newborn guinea pig","volume":"9","author":"Moessinger","year":"1987","journal-title":"J Dev Physiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1542\/peds.2006-3668","article-title":"Effect of a short course of prednisolone in infants with oxygen-dependent bronchopulmonary dysplasia","volume":"121","author":"Bhandari","year":"2008","journal-title":"Pediatrics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002(SICI)1520-6661(199901\/02)8:1%3C20::AID-MFM5%3E3.0.CO;2-7","article-title":"Impact of oligohydramnios on maternal and perinatal outcomes of spontaneous premature rupture of the membranes at 18\u201328 weeks","volume":"8","author":"Shumway","year":"1999","journal-title":"J Matern Fetal Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1080\/14767058.2018.1553944","article-title":"Delivery mode and perinatal outcomes after diagnosis of oligohydramnios at term in China","volume":"33","author":"Hou","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2195523","DOI":"10.1080\/14767058.2023.2195523","article-title":"Impact of preterm premature rupture of membranes and oligohydramnios on in-hospital outcomes of very-low-birthweight infants","volume":"36","author":"Kim","year":"2023","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.18203\/2320-1770.ijrcog20220153","article-title":"Maternal complications and neonatal outcomes in oligohydramnios","volume":"11","author":"Rahman","year":"2022","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12978-020-0854-y","article-title":"Oligohydramnios: a prospective study of fetal, neonatal and maternal outcomes in low-middle income countries\u2019","volume":"17","author":"Figueroa","year":"2020","journal-title":"Reprod Health"},{"key":"B19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/uog.10095","article-title":"Prediction and probability of neonatal outcome in isolated congenital diaphragmatic hernia using multiple ultrasound parameters","volume":"39","author":"Ruano","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1007\/s00247-011-2199-8","article-title":"Fetal MRI for prediction of neonatal mortality following preterm premature rupture of the fetal membranes","volume":"41","author":"Messerschmidt","year":"2011","journal-title":"Pediatr Radiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0028-2243(87)90138-9","article-title":"Lethal lung hypoplasia in infants after prolonged rupture of membranes","volume":"25","author":"van Dongen","year":"1987","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/0002-9378(91)91442-Y","article-title":"Significance of oligohydramnios complicating pregnancy","volume":"164","author":"Shenker","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.earlhumdev.2008.11.003","article-title":"1,22 neonatal outcome following rupture of membranes prior to 25 weeks with prolonged oligohydramnios","volume":"85","author":"Williams","year":"2009","journal-title":"Early Hum Dev"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1067\/mob.2000.107435","article-title":"Neonatal pulmonary hypoplasia and perinatal mortality in patients with midtrimester rupture of amniotic membranes\u2014a critical analysis","volume":"182","author":"Winn","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1136\/adc.63.2.190","article-title":"Dry lung sundrome after oligohydramnios","volume":"63","author":"McIntosh","year":"1988","journal-title":"Arch Dis Child"},{"key":"B26","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0022-3476(85)80148-7","article-title":"Neonatal pulmonary hypoplasia with premature rupture of fetal membranes and oligohydramnios","volume":"107","author":"Thibeault","year":"1985","journal-title":"J Pediatr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12884-016-0813-3","article-title":"Neonatal and maternal outcomes following midtrimester preterm premature rupture of the membranes: a retrospective cohort study","volume":"16","author":"Linehan","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1136\/adc.63.10_Spec_No.1146","article-title":"Neonatal outcome after prolonged rupture of the membranes starting in the second trimester","volume":"63","author":"Blott","year":"1988","journal-title":"Arch Dis Child"},{"key":"B29","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.earlhumdev.2012.01.012","article-title":"Two-year neonatal outcome following PPROM prior to 25 weeks with prolonged period of oligohydramnios","volume":"88","author":"Williams","year":"2012","journal-title":"Early Hum Dev"},{"key":"B30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejogrb.2021.08.007","article-title":"Maternal, perinatal and childhood outcomes of the PPROMEXILIII cohort: pregnancies complicated by previable prelabor rupture of membranes","volume":"265","author":"Simons","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1457129\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T14:39:42Z","timestamp":1736951982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1457129\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":30,"alternative-id":["10.3389\/fped.2024.1457129"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1457129","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"article-number":"1457129"}}