{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:56:19Z","timestamp":1768424179679,"version":"3.49.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gallstones are among the most common complications of hereditary spherocytosis (HS). In previous treatments, gallbladder-preserving cholelithotomy (GPC) has remained a subject of significant debate due primarily to potential risks of stone recurrence. However, past studies have often overlooked the impact of specific disease conditions on GPC. In this study, we reviewed the clinical data of GPC in HS pediatric patients with concurrent gallstones over a period of seven years in a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2016 to April 2024, 32 pediatric patients with HS who underwent splenectomy and GPC surgery based on our inclusion criteria. Clinical pathological, and follow-up data of these patients were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of short-term complications, there were there were no cases of postoperative bleeding, bile duct injury. 3 cases (9.3%) experienced varying degrees of bile peritonitis. During long-term follow-up, only 2 cases (6.2%) showed recurrence of gallstones. One case of bile leakage occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GPC demonstrates significant efficacy for pediatric patients with hereditary spherocytosis (HS) complicated by gallstones, showing a a low recurrence rate and high safety profile.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1457927","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T04:37:59Z","timestamp":1732077479000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Gallbladder preserving cholelithotomy in children with hereditary spherocytosis complicated by gallstones: a single-center retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Ran","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-xiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-cheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-qin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.5582\/irdr.2015.01002","article-title":"A systematic review of hereditary spherocytosis reported in Chinese biomedical journals from 1978 to 2013 and estimation of the prevalence of the disease using a disease model","volume":"4","author":"Wang","year":"2015","journal-title":"Intractable Rare Dis Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1365-2141.2011.08921.x","article-title":"Guidelines for the diagnosis and management of hereditary spherocytosis\u20132011 update","volume":"156","author":"Bolton-Maggs","year":"2012","journal-title":"Br J Haematol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/S0140-6736(08)61588-3","article-title":"Hereditary spherocytosis","volume":"372","author":"Perrotta","year":"2008","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3892\/or.2018.6578","article-title":"Analysis of the causes of the misdiagnosis of hereditary spherocytosis","volume":"40","author":"Ma","year":"2018","journal-title":"Oncol Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.surg.2022.08.008","article-title":"A new operation for gallstones: choledochoscopic gallbladder-preserving cholecystolithotomy, a retrospective study of 3,511 cases","volume":"172","author":"Liu","year":"2022","journal-title":"Surgery"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.2214\/ajr.145.5.1009","article-title":"Sonographic measurement of gallbladder volume","volume":"145","author":"Dodds","year":"1985","journal-title":"AJR Am J Roentgenol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1097\/00043426-200312000-00009","article-title":"High incidence of early cholelithiasis detected by ultrasonography in children and young adults with hereditary spherocytosis","volume":"25","author":"Tamary","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1053\/j.seminhematol.2004.01.002","article-title":"Hereditary spherocytosis\u2013defects in proteins that connect the membrane skeleton to the lipid bilayer","volume":"41","author":"Eber","year":"2004","journal-title":"Semin Hematol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1182\/blood.V100.6.2208","article-title":"Splenectomy prolongs in vivo survival of erythrocytes differently in spectrin\/ankyrin- and band 3-deficient hereditary spherocytosis","volume":"100","author":"Reliene","year":"2002","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/j.1582-4934.2008.00572.x","article-title":"Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions","volume":"13","author":"Sahu","year":"2009","journal-title":"J Cell Mol Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.surg.2013.04.040","article-title":"Etiology and incidence of pediatric gallbladder disease","volume":"154","author":"Walker","year":"2013","journal-title":"Surgery"},{"key":"B12","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1445-2197.2008.04539.x","article-title":"Diarrhoea after laparoscopic cholecystectomy: incidence and main determinants","volume":"78","author":"Fisher","year":"2008","journal-title":"Anz J Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/S0022-3468(99)90569-9","article-title":"The role of prophylactic cholecystectomy during splenectomy in children with hereditary spherocytosis","volume":"34","author":"Sandler","year":"1999","journal-title":"J Pediatr Surg"},{"key":"B14","first-page":"199","article-title":"Gallstone recurrence after successful percutaneous cholecystolithotomy: a 10-year follow-up of 439 cases","volume":"6","author":"Zou","year":"2007","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1053\/jpsu.2001.27035","article-title":"Cholecystectomy versus cholecystolithotomy for cholelithiasis in childhood: long-term outcome","volume":"36","author":"De Caluwe","year":"2001","journal-title":"J Pediatr Surg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/SLE.0b013e31828a0b5f","article-title":"Gallbladder-preserving cholelithotomy in laparoscopic and flexible choledochoscopic era: a report of 316 cases","volume":"23","author":"Zha","year":"2013","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"B17","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.jpedsurg.2022.11.012","article-title":"Treatment of asymptomatic gallstones in children with hereditary spherocytosis requiring splenectomy","volume":"58","author":"Liu","year":"2023","journal-title":"J Pediatr Surg"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1457927\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T04:38:02Z","timestamp":1732077482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1457927\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":17,"alternative-id":["10.3389\/fped.2024.1457927"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1457927","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"article-number":"1457927"}}