{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:07:53Z","timestamp":1774260473516,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital biliary dilatation (CBD) is a congenital malformation of the main biliary tract usually associated with the pancreatobiliary maljunction (PBM), determining stone formation, cholangitis, pancreatitis, and cholangiocarcinoma. The role of endoscopic retrograde cholangiopancreatography (ERCP) in treatment and diagnosis has not been established yet. Therefore, the aim of our study is to define the actual role of ERCP in children with CBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of consecutive patients with congenital biliary dilatation undergoing preoperative ERCP and subsequent surgical treatment at our pediatric tertiary referral center (Endoscopy and Digestive Surgery, Bambino Ges\u00f9 Children's Hospital, IRCCS, Rome, Italy) was performed between 2012 and 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 31 patients were included in the present study. Preoperative ERCP detected a PBM in 28 patients (90%). According to Todani's classification, 2 patients (6.5%) had choledochal cyst (CC) type IV, and 29 patients (93.5%) were diagnosed with CC type I. In 18 (58%) patients, ERCP was performed for treating acute pancreatitis. Sphincterotomy could be performed in 23 of 31 (74%) patients. Patients who did not undergo sphincterotomy had a higher number of acute episodes while awaiting surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study is supportive of an essential role of ERCP in the diagnostic and preoperative management of children with CBD with acute presentation or inconclusive magnetic resonance cholangiopancreatography findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1484375","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:59:19Z","timestamp":1736146759000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic retrograde cholangiopancreatography in children with pediatric congenital biliary dilatation associated with pancreatobiliary maljunction: experience from a tertiary center"],"prefix":"10.3389","volume":"12","author":[{"given":"Giovanni","family":"Rollo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Balassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Faraci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Torroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Dall'Oglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Caldaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/jhbp.485","article-title":"Classification of pancreaticobiliary maljunction and clinical features in children","volume":"24","author":"Urushihara","year":"2017","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/BF02489025","article-title":"Congenital choledochal dilatation: classification, clinical features, and long-term results","volume":"4","author":"Todani","year":"1997","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00383-017-4083-6","article-title":"Pediatric choledochal cysts: diagnosis and current management","volume":"33","author":"Soares","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"B4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00383-004-1252-1","article-title":"Roux-en-Y hepaticojejunostomy or hepaticoduodenostomy for biliary reconstruction during the surgical treatment of choledochal cyst: which is better?","volume":"21","author":"Shimotakahara","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00383-023-05483-1","article-title":"Choledochal cyst","volume":"39","author":"Cazares","year":"2023","journal-title":"Pediatr Surg Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/den.14081","article-title":"Preoperative biliary drainage for pancreatic cancer","volume":"34","author":"Nehme","year":"2022","journal-title":"Dig Endosc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S2468-1253(17)30002-X","article-title":"Pancreaticobiliary maljunction and congenital biliary dilatation","volume":"2","author":"Kamisawa","year":"2017","journal-title":"Review Lancet Gastroenterol Hepatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/MPG.0000000000000399","article-title":"Role of pediatric endoscopic retrograde cholangiopancreatography in an era stressing less-invasive imaging modalities","volume":"59","author":"Saito","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jhbp.415","article-title":"Japanese clinical practice guidelines for congenital biliary dilatation","volume":"24","author":"Ishibashi","year":"2017","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.jpedsurg.2012.01.040","article-title":"Role of endoscopic retrograde cholangiopancreatography in diagnosis and management of congenital choledochal cysts: 28 pediatric cases","volume":"47","author":"De Angelis","year":"2012","journal-title":"J Pediatr Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/01.mpg.0000361657.54810.19","article-title":"Post-ERCP pancreatitis in pediatric patients","volume":"49","author":"Iqbal","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/MPG.0b013e31824f1516","article-title":"Definitions of pediatric pancreatitis and survey of present clinical practices","volume":"55","author":"Morinville","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.gie.2009.10.027","article-title":"A lexicon for endoscopic adverse events: report of an ASGE workshop","volume":"71","author":"Cotton","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1016\/j.jpedsurg.2012.12.038","article-title":"Pancreatic complications in pediatric choledochal cysts","volume":"48","author":"Fujishiro","year":"2013","journal-title":"J Pediatr Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00005176-200003000-00025","article-title":"Endoscopic retrograde cholangiopancreatography in children","volume":"30","author":"Fox","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.bpg.2016.09.006","article-title":"Complications in pediatric endoscopy","volume":"30","author":"Tringali","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"44860","DOI":"10.18632\/oncotarget.16228","article-title":"Endoscopic therapy for patients with pancreaticobiliary maljunction: a follow-up study","volume":"8","author":"Jin","year":"2017","journal-title":"Oncotarget"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/j.gie.2014.11.022","article-title":"Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population","volume":"81","author":"Troendle","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"B19","first-page":"430","article-title":"Post-ERCP pancreatitis in pediatric patients","volume-title":"J Pediatr Gastroenterol Nutr","author":"Iqbal","year":"2009"},{"key":"B20","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1097\/MPG.0000000000003766","article-title":"Risk factors for post-ERCP pancreatitis in pediatric and young adult patients","volume":"76","author":"Hassan","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.gie.2010.12.036","article-title":"Grading the complexity of endoscopic procedures: results of an ASGE working party","volume":"73","author":"Cotton","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"B22","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/MPG.0000000000003762","article-title":"Pediatric ERCP in the setting of acute pancreatitis: a secondary analysis of an international multicenter cohort study","volume":"76","author":"Trocchia","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1484375\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:59:21Z","timestamp":1736146761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1484375\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":22,"alternative-id":["10.3389\/fped.2024.1484375"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1484375","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"article-number":"1484375"}}