{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:53:29Z","timestamp":1792601609509,"version":"4.5.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Macrolide-unresponsive\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (MUMPP) cases have been rapidly increasing. The primary reason for this increased incidence is the pathogen's acquisition of resistance through mutations in 23S rRNA genes. Due to the unfeasibility of testing for macrolide susceptibility at the time of admission, this study aimed to assess the clinical features of pediatric MUMPP, using insights from laboratory tests and patterns of chest radiographic resolution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective review of 161 patients with\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      pneumonia (MPP) between January 2023 and December 2023. These patients were categorized into two groups based on their responsiveness to macrolides: 72 patients were in the MUMPP group, and 89 patients were in the macrolide-sensitive\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (MSMP) group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MUMPP patients experienced a longer duration of fever and hospital stay. A higher proportion of MUMPP patients had shortness of breath, transcutaneous blood oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) lower than 94%, bilateral lobar infiltrates, lobar pneumonia and pleural effusion. The serum level of serum ferritin (SF), interleukin-6(IL-6), D-dimer, lactate dehydrogenase to albumin rate (LAR), and neutrophil to lymphocyte rate (NLR) were higher in MUMPP group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings revealed that patients with MUMPP exhibit more severe initial radiographic indicators and clinical course compared to those with MSMP. Therefore, it is crucial to promptly administer alternative therapeutic agents besides macrolides for the management of MUMPP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2024.1489389","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T23:23:34Z","timestamp":1733181814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical characteristics and predictive indictors of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in children: a retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Yun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20073","DOI":"10.2807\/ese.17.05.20073-en","article-title":"Epidemic of mycoplasma pneumoniae infection in Denmark, 2010 and 2011","volume":"17","author":"Uldum","year":"2012","journal-title":"Eurosurveillance"},{"key":"B2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1056\/NEJMoa1500245","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. adults","volume":"373","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1017\/s0950268819000839","article-title":"The epidemiology of paediatric mycoplasma pneumoniae pneumonia in north China: 2006 to 2016","volume":"147","author":"Gao","year":"2019","journal-title":"Epidemiol Infect"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1900112","DOI":"10.2807\/1560-7917.Es.2020.25.2.1900112","article-title":"Mycoplasma pneumoniae infections, 11 countries in Europe and Israel, 2011 to 2016","volume":"25","author":"Beeton","year":"2020","journal-title":"Eurosurveillance"},{"key":"B5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ppul.25721","article-title":"Viruses and mycoplasma pneumoniae are the main etiological agents of community-acquired pneumonia in hospitalized pediatric patients in Spain","volume":"57","author":"Otheo","year":"2022","journal-title":"Pediatr Pulmonol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12519-023-00783-x","article-title":"Current status of mycoplasma pneumoniae infection in China","volume":"20","author":"Yan","year":"2024","journal-title":"World J Pediatr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e763","DOI":"10.1016\/S2666-5247(23)00182-9","article-title":"Mycoplasma pneumoniae: gone forever?","volume":"4","author":"Meyer Sauteur","year":"2023","journal-title":". 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