{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:08:02Z","timestamp":1781294882579,"version":"3.54.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Congenital diarrhea and enteropathies (CODEs) are a rare heterogeneous group of inherited disorders that typically present with severe chronic diarrhea during the first weeks of life. As a broad range of illnesses can present similarly in infants, establishing a definitive cause for CODEs is challenging. In this report, two infants were suspected to have CODE, with neonatal-onset chronic diarrhea and protein-losing enteropathy finally found to be due to intestinal malrotation and chronic midgut volvulus. Although the disease onset time was during the neonatal period, the typical findings of intestinal malrotation and volvulus were not present. Following the diagnostic approach for CODEs, both patients underwent extensive examinations without a definitive diagnosis. Intestinal malrotation was incidentally detected by an abdominal CT examination. After surgical correction of the underlying malrotation (Ladd's procedure), both infants had resolution of their diarrhea and hypoalbuminemia.<\/jats:p>","DOI":"10.3389\/fped.2024.1494599","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:11:17Z","timestamp":1736835077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Neonatal onset intractable diarrhea and hypoproteinemia due to intestinal malrotation and chronic midgut volvulus"],"prefix":"10.3389","volume":"12","author":[{"given":"Cuifang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiran","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1053\/j.gastro.2018.03.067","article-title":"Advances in evaluation of chronic diarrhea in infants","volume":"154","author":"Thiagarajah","year":"2018","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.surg.2010.07.004","article-title":"Intestinal malrotation: varied clinical presentation from infancy through adulthood","volume":"149","author":"Nehra","year":"2011","journal-title":"Surgery"},{"key":"B3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.earlhumdev","article-title":"Malrotation and intestinal atresias","volume":"90","author":"Adams","year":"2014","journal-title":"Early Hum Dev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1016\/j.jemermed","article-title":"Intestinal malrotation and catastrophic volvulus in infancy","volume":"43","author":"Lee","year":"2012","journal-title":"J Emerg Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/s0009-9260(89)80280-6","article-title":"Malrotation and midgut volvulus presenting as malabsorption","volume":"40","author":"Jackson","year":"1989","journal-title":"Clin Radiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/0022-3468(90)90749-y","article-title":"Malrotation presenting beyond the neonatal period","volume":"25","author":"Spigland","year":"1990","journal-title":"J Pediatr Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1442-200x.2004.01859.x","article-title":"Rare clinical presentation mode of intestinal malrotation after neonatal period: malabsorption-like symptoms due to chronic midgut volvulus","volume":"46","author":"Imamoglu","year":"2004","journal-title":"Pediatr Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e515","DOI":"10.1542\/peds.2011-0937","article-title":"Malrotation of the intestine and chronic volvulus as a cause of protein-losing enteropathy in infancy","volume":"129","author":"Zellos","year":"2012","journal-title":"Pediatrics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1111\/jpc.14986","article-title":"Chronic diarrhoea in children: a practical algorithm-based approach","volume":"56","author":"Shankar","year":"2020","journal-title":"J Paediatr Child Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/MOG.0000000000000629","article-title":"Protein-losing enteropathy","volume":"36","author":"Elli","year":"2020","journal-title":"Curr Opin Gastroenterol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00431-010-1235-2","article-title":"Clinical practice. 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