{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:42:39Z","timestamp":1790923359886,"version":"4.1.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Transient tachypnea of the newborn (TTN) is generally self-limiting. The increasing incidence of severe cases and lack of comprehensive studies on its clinical outcomes and influencing factors highlight the need for improved diagnostic and monitoring tools. This study aimed to assess the lung ultrasonographic features, recovery durations, and factors influencing TTN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred neonates with wet lungs were selected as the TTN group and divided into mild (132\/200) and severe (68\/200) groups. Two hundred neonates without pulmonary disease served as controls. The acute-phase lung ultrasonographic features of the two groups were compared. According to the clinical recovery duration, TTN group was divided into group A (&amp;lt;5 days, 191\/200) and group B (\u22655 days, 9\/200). Univariate and multivariate logistic regression analyses were used to analyze the relationship between clinically relevant factors and the recovery time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The time that was required for the 200 neonates to fully recover without symptoms was 2.3\u2009\u00b1\u20091.33 days. The average clinical recovery durations of neonates with mild illness, those who required non-invasive ventilation, and those who required invasive ventilation were 1.42\u2009\u00b1\u20090.50, 3.36\u2009\u00b1\u20090.51, and 6.00\u2009\u00b1\u20091.12 days, respectively. The differences between the groups were significant (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). Type II respiratory failure, acute respiratory distress syndrome (ARDS), persistent pulmonary hypertension of the newborn (PPHN), and heart failure were important factors affecting the recovery time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lung ultrasonographic signs differed based on the degree of wet lungs. Moreover, type II respiratory failure, ARDS, PPHN, and heart failure are important factors prolonging the course of TTN in neonates.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2024.1536992","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:52:50Z","timestamp":1737096770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lung ultrasound to evaluate the outcome and prognosis of transient tachypnea of the newborn"],"prefix":"10.3389","volume":"12","author":[{"given":"Peng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1053\/j.semperi.2006.01.006","article-title":"Physiology of fetal lung fluid clearance and the effect of labor","volume":"30","author":"Jain","year":"2006","journal-title":"Semin Perinatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.clp.2012.09.009","article-title":"Physiology of transition from intrauterine to extrauterine life","volume":"39","author":"Hillman","year":"2012","journal-title":"Clin Perinatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1651-2227.2004.tb02990.x","article-title":"Neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery","volume":"93","author":"Zanardo","year":"2004","journal-title":"Acta Paediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e680","DOI":"10.1542\/neo.16-12-e680","article-title":"Persistent pulmonary hypertension of the newborn","volume":"16","author":"Lakshminrusimha","year":"2015","journal-title":"Neoreviews"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1097\/MD.0000000000000197","article-title":"Diagnosis of neonatal transient tachypnea and its differentiation from respiratory distress syndrome using lung ultrasound","volume":"93","author":"Liu","year":"2014","journal-title":"Medicine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.chest.2015.12.024","article-title":"Lung ultrasonography to diagnose transient tachypnea of the newborn","volume":"149","author":"Liu","year":"2016","journal-title":"Chest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1055\/s-2005-872594","article-title":"Cesarean section, gestational age, and transient tachypnea of the newborn: timing is the key","volume":"22","author":"Riskin","year":"2005","journal-title":"Am J Perinatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3760\/cma.j.issn.2095-428X.2016.02.004","article-title":"The value of lung ultrasound in diagnosing transient tachypnea of the newborn","volume":"31","author":"Jing","year":"2016","journal-title":"Chin J Appl Clin Pediatr"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3791\/58990","article-title":"Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus","author":"Liu","year":"2019","journal-title":"J Vis Exp"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0248827","DOI":"10.1371\/journal.pone.0248827","article-title":"Diagnostic performance of lung ultrasound for transient tachypnea of the newborn: a meta-analysis","volume":"16","author":"He","year":"2021","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1080\/14767058.2021.1940943","article-title":"Specification and guideline for technical aspects and scanning parameter settings of neonatal lung ultrasound examination","volume":"35","author":"Liu","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.5812\/ijp.323","article-title":"The role of lung ultrasound in diagnosis of respiratory distress syndrome in newborn infants","volume":"25","author":"Liu","year":"2015","journal-title":"Iran J Pediatr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/ALN.0000000000000300","article-title":"Lung ultrasound predicts well extravascular lung water but is of limited usefulness in the prediction of wedge pressure","volume":"121","author":"Volpicelli","year":"2014","journal-title":"Anesthesiology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/ppul.22585","article-title":"Lung ultrasound characteristics of community-acquired pneumonia in hospitalized children","volume":"48","author":"Caiulo","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/emj.2010.101584","article-title":"Lung ultrasound is an accurate diagnostic tool for the diagnosis of pneumonia in the emergency department","volume":"29","author":"Cortellaro","year":"2012","journal-title":"Emerg Med J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"L1324","DOI":"10.1152\/ajplung.2001.281.6.L1324","article-title":"Pulmonary edema fluid movement within the lung","volume":"281","author":"O\u2019Brodovich","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e151797","DOI":"10.1001\/jamapediatrics.2015.1797","article-title":"Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure","volume":"169","author":"Brat","year":"2015","journal-title":"JAMA Pediatr"},{"key":"B18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pedneo.2020.09.002","article-title":"Prospective investigation of serial ultrasound for transient tachypnea of the newborn","volume":"62","author":"Li","year":"2021","journal-title":"Pediatr Neonatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.arcped.2017.11.005","article-title":"Can a simple lung ultrasound score predict length of ventilation for infants with severe acute viral bronchiolitis?","volume":"25","author":"Taveira","year":"2018","journal-title":"Arch Pediatr"},{"key":"B20","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.jpeds.2011.04.023","article-title":"Surfactant deficiency in transient tachypnea of the newborn","volume":"159","author":"Machado","year":"2011","journal-title":"J Pediatr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1080\/14767058.2016.1261281","article-title":"Perinatal risk factors for pneumothorax and morbidity and mortality in very low birth weight infants","volume":"30","author":"Garc\u00eda-Mu\u00f1oz Rodrigo","year":"2017","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1536992\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:52:53Z","timestamp":1737096773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2024.1536992\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":21,"alternative-id":["10.3389\/fped.2024.1536992"],"URL":"https:\/\/doi.org\/10.3389\/fped.2024.1536992","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]},"article-number":"1536992"}}