{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:33:35Z","timestamp":1790314415872,"version":"4.1.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Premature death is a serious health concern in developing countries, including Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted in Hawassa University Comprehensive Specialized Hospital from 9 May 2019 to 22 April 2021. A total of 723 preterm neonates were enrolled in this study. The Kaplan\u2013Meier survival curve was used to calculate the survival rate. The Cox proportional hazard ratio was used to evaluate the relationship between the dependent and independent variables. A 95% confidence level was used to check for significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm neonatal mortality accounted for 33.3% of neonatal admissions. Early neonatal sepsis [adjusted hazard ratio (AHR)\u2009=\u20091.34; 95% CI: 1.003, 1.79], a 5-min Apgar score of less than 7 (AHR\u2009=\u20091.73; 95% CI: 1.17, 2.55), perinatal asphyxia (AHR\u2009=\u20092.25; 95% CI: 1.67, 3.02), and recent multiple pregnancies (AHR\u2009=\u20091.66; 95% CI: 1.22, 2.26) were predictors of preterm neonatal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early breastfeeding, prevention and early treatment of perinatal hypoxia and neonatal infections, identification, and monitoring of multiple pregnancies could help to reduce preterm neonatal mortality.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1414127","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:28:54Z","timestamp":1758259734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of preterm neonatal mortality in the neonatal intensive care unit at a tertiary medical institution in Ethiopia"],"prefix":"10.3389","volume":"13","author":[{"given":"Tihun","family":"Feleke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudeta","family":"Kaweti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"B1","volume-title":"Born Too Soon: The Global Action Report on Preterm Birth","year":"2021"},{"key":"B2","volume-title":"United Nations Interagency Group for Child Mortality Estimation (UN IGME)","year":"2020"},{"key":"B3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.placenta.2019.01.007","article-title":"Determinants and outcomes of preterm births at a tertiary hospital in Ghana","volume":"79","author":"Adu-Bonsaffoh","year":"2019","journal-title":"Placenta"},{"key":"B4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ijgo.13195","article-title":"Global burden of preterm birth","volume":"150","author":"Walani","year":"2020","journal-title":"Int J Obstet Gynaecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/PHMT.S266675","article-title":"Preterm neonatal mortality and its determinants at a tertiary hospital in western Uganda: a prospective cohort study","volume":"11","author":"Egesa","year":"2020","journal-title":"Pediatric Health Med Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4274\/tjod.62582","article-title":"The incidence, risk factors, and mortality of preterm neonates: a prospective study from Jordan (2012\u20132013)","volume":"14","author":"Abdel Razeq","year":"2017","journal-title":"Turk J Obstet Gynecol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246005","article-title":"Determinants of preterm survival in a tertiary hospital in Ghana: a ten-year review","volume":"16","author":"Evans Kofi Agbeno","year":"2021","journal-title":"PLoS One"},{"key":"B9","article-title":"World Prematurity Day: improving survival and quality of life for millions of babies born preterm around the world. 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