{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:28:50Z","timestamp":1759940930168,"version":"3.41.2"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Pheochromocytomas (PCCs) are rare neuroendocrine tumors originating from the adrenal medulla, particularly uncommon in pediatric populations. This case report presents a 12-year-old boy with a three-year history of fatigue and a one-year history of blurred vision, who was admitted with severe hypertension (230\/200\u2005mmHg). Abdominal CT imaging revealed bilateral adrenal masses measuring 40\u2005mm on the left and 12\u2005mm on the right. The diagnosis of pheochromocytoma was confirmed by elevated blood catecholamine metabolites. During perioperative preparation, the patient experienced complications, including polyuria, thrombosis, and infection, necessitating an emergency resection of the right adrenal tumor. This intervention led to a successful recovery. Subsequent genetic testing identified a mutation in the VHL gene. After further medical management, the left adrenal tumor was also successfully removed. At one-year follow-up, the patient remained normotensive with no signs of recurrence. This case emphasizes the critical role of genetic testing and cutious perioperative management in the treatment of pediatric pheochromocytoma.<\/jats:p>","DOI":"10.3389\/fped.2025.1439186","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:04:27Z","timestamp":1739257467000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive case report and literature review on perioperative management of multiple pheochromocytoma in a pediatric patient"],"prefix":"10.3389","volume":"13","author":[{"given":"Shenghua","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yani","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guili","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00467-018-4181-2","article-title":"Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management","volume":"35","author":"Jain","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/MOU.0000000000000650","article-title":"Pediatric pheochromocytoma: current status of diagnostic imaging and treatment procedures","volume":"29","author":"Peard","year":"2019","journal-title":"Curr Opin Urol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3389\/fped.2017.00155","article-title":"Review of pediatric pheochromocytoma and paraganglioma","volume":"5","author":"Bholah","year":"2017","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"586795","DOI":"10.3389\/fendo.2020.586795","article-title":"Preoperative management of pheochromocytoma and paraganglioma","volume":"11","author":"Fang","year":"2020","journal-title":"Front Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"400.e1","DOI":"10.1016\/j.jpurol.2021.01.043","article-title":"Approach to pheochromocytoma and paraganglioma in children and adolescents: a retrospective clinical study from a tertiary care center","volume":"17","author":"Ardicli","year":"2021","journal-title":"J Pediatr Urol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1210\/jc.2007-1720","article-title":"Preoperative management of the pheochromocytoma patient","volume":"92","author":"Pacak","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1053\/j.jvca.2017.02.023","article-title":"Perioperative management of pheochromocytoma","volume":"31","author":"Naranjo","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B8","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0140-6736(05)67139-5","article-title":"Phaeochromocytoma","volume":"366","author":"Lenders","year":"2005","journal-title":"Lancet"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1439186\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:04:29Z","timestamp":1739257469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1439186\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":8,"alternative-id":["10.3389\/fped.2025.1439186"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1439186","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2025,2,11]]},"article-number":"1439186"}}