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Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical features, complications, diagnosis and management of congenital hepatic hemangiomas(CHHs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>12 neonates of CHH admitted to our hospital in the past 10 years were retrospectively analyzed, and the clinical manifestations, auxiliary examination results, diagnosis and treatment methods, clinical efficacy andprognosis were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, 12 neonates with CHHs were reported. Among them, 8 cases underwent surgical treatment and recovered well postoperatively. 3 cases received routine pharmacological treatment, were gradually recovering. Only one case, presenting with giant CHH and congestive heart failure (CHF) at birth, failed initial pharmacological treatment and underwent percutaneous hepatic hemangioma embolization but died postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Large CHHs tend to be complicated with refractory congestive heart failure, likely due to tumor size and intra-tumor arteriovenous shunt. Propranolol is effective for CHHs with stable hemodynamics but has a slow onset of action, making it less suitable for cases complicated with CHF. Surgical resection is effective and recommended for large CHHs with stable hemodynamics, while percutaneous hepatic hemangioma embolization is advised for unstable cases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1453019","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:34:17Z","timestamp":1745818457000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A report of 12 cases of congenital hepatic hemangioma and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Ying","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.11786\/sypfbxzz.1674-1293.20180203","article-title":"Analysis on epidemiological and clinical features of 2761 cases of infantile hemangioma","volume":"11","author":"Yan","year":"2018","journal-title":"J Pract Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3760\/j.issn:1002-0098.2005.03.008","article-title":"Diagnosis and treatment of congenital hemangioma and vascular malformations","volume":"40","author":"Zhao","year":"2005","journal-title":"Chin J Stomatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1007\/s12072-024-10756-5","article-title":"Clinical characteristics and managements of congenital hepatic hemangioma: a cohort study of 211 cases","volume":"40","author":"Gong","year":"2024","journal-title":"Hepatol Int"},{"key":"B4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/his.14114","article-title":"The histopathology of congenital haemangioma and its clinical correlations: a long-term follow-up study of 55 cases","volume":"77","author":"El Zein","year":"2020","journal-title":"Histopathology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jpeds.2018.08.012","article-title":"Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring","volume":"203","author":"Iacobas","year":"2018","journal-title":"J Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"adv00849","DOI":"10.2340\/actadv.v103.3983","article-title":"A case series of 18 congenital haemangiomas: clinical, histological and ultrasound features, and their relationship with complications and atypical behaviour","volume":"103","author":"Juan-Carpena","year":"2023","journal-title":"Acta Derm Venereol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.1111\/j.1525-1470.2012.01875.x","article-title":"Congenital cutaneous hemangioma causing cardiac failure: a case report and review of the literature","volume":"30","author":"Weitz","year":"2013","journal-title":"Pediatr Dermatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e172836","DOI":"10.1172\/JCI172836","article-title":"Infantile hemangioma: the common and enigmatic vascular tumor","volume":"134","author":"Holm","year":"2024","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"pbac006","DOI":"10.1093\/pcmedi\/pbac006","article-title":"Infantile hepatic hemangiomas: looking backwards and forwards","volume":"5","author":"Gong","year":"2022","journal-title":"Precis Clin Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s40477-022-00714-y","article-title":"Hepatic hemangiomas in childhood: the Spectrum of radiologic findings. 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