{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:46Z","timestamp":1790279146997,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>We describe the rare case of a previously healthy seven year-old boy, with an acute clinical onset of severe pulmonary hypertension. He recovered rapidly after vitamin supplementation. Patient history showed a highly selective food intake in the context of autistic features. Thiamine deficiency seemed to be the predominant causing factor aggravated by moderate iron deficiency and supposed vitamin C deficiency. Dietary impact on pulmonary pressures is still poorly understood, but it seems that micronutrient deficiency could be a rare cause of pulmonary hypertension. Relatively frequent in developing countries and mostly in infants, thiamine deficiency should not be forgotten as a potential etiology in the differential diagnosis when patient dietary history is particular.<\/jats:p>","DOI":"10.3389\/fped.2025.1478889","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:43:25Z","timestamp":1738305805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: severe pulmonary hypertension in a child with micronutrient deficiency"],"prefix":"10.3389","volume":"13","author":[{"given":"Laure","family":"Pache-Wannaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Voicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Boillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sekarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2401345","DOI":"10.1183\/13993003.01345-2024","article-title":"Embracing the challenges of neonatal and paediatric pulmonary hypertension","volume":"64","author":"Ivy","year":"2024","journal-title":"Eur Respir J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur Respir J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/nu12010169","article-title":"Impact of nutrition on pulmonary arterial hypertension","volume":"12","author":"Callejo","year":"2020","journal-title":"Nutrients"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","article-title":"Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society","volume":"132","author":"Abman","year":"2015","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.3390\/nu13113923","article-title":"Prevalence of micronutrient deficiencies and relationship with clinical and patient-related outcomes in pulmonary hypertension types I and IV","volume":"13","author":"Vinke","year":"2021","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e12173","DOI":"10.1002\/pul2.12173","article-title":"Nutritional status in pulmonary arterial hypertension","volume":"12","author":"Kwant","year":"2022","journal-title":"Pulm Circ"},{"key":"B7","doi-asserted-by":"publisher","first-page":"928026","DOI":"10.3389\/fnut.2022.928026","article-title":"Case report: vitamin C combined with multiple micronutrient deficiencies is associated with pulmonary arterial hypertension in children with autistic spectrum disorder","volume":"9","author":"Sakamornchai","year":"2022","journal-title":"Front Nutr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jpeds.2018.12.068","article-title":"Pulmonary hypertension secondary to scurvy in a developmentally typical child","volume":"208","author":"Frank","year":"2019","journal-title":"J Pediatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2045894018812052","DOI":"10.1177\/2045894018812052","article-title":"Cardiac arrest and pulmonary hypertension in scurvy: a case report","volume":"9","author":"Dean","year":"2019","journal-title":"Pulm Circ"},{"key":"B10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/20469047.2021.1901406","article-title":"Reversible right-sided heart failure and pulmonary hypertension caused by scurvy in a 7-year-old boy with autism spectrum disorder and a review of the literature","volume":"43","author":"Abe","year":"2023","journal-title":"Paediatr Int Child Health"},{"key":"B11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1213\/XAA.0000000000001087","article-title":"Pulmonary hypertensive crisis during general anesthesia in a 3-year-old autistic boy with undiagnosed scurvy. 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