{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:38:53Z","timestamp":1764333533079,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the early alterations in the architecture and performance of the left ventricle for childhood-onset systemic lupus erythematosus (cSLE) patients utilizing three-dimensional speckle tracking imaging (3D-STI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aggregate of 31 cSLE patients were recruited and categorized into two groups based on the SLE disease activity index (SLEDAI) score: the mild-to-moderate group (\u226412, <jats:italic>n<\/jats:italic>\u2009=\u200914) and the severe group (&amp;gt;12, <jats:italic>n<\/jats:italic>\u2009=\u200917). Univariate as well as multivariate logistic regression were used to investigate the relationship between 3D-STI parameters and the activity of the disease. Four diagnostic patterns were employed to amalgamate 3D-STI data (global longitudinal strain, GLS, and left ventricular twist angle, LVtw): isolation, series, parallel, and integration, subsequently leading to the development of a 3D myocardial comprehensive index (3D-MCI). The primary aim was severe disease activity, whereas the secondary objectives were growth failure, lupus nephritis, hypocomplementemia, and serious hematological issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariate analysis, GLS and LVtw emerged as significant indicators of severe disease activity (<jats:italic>p<\/jats:italic>\u2009=\u20090.028 and <jats:italic>p<\/jats:italic>\u2009=\u20090.047). The comprehensive method, which integrates GLS with LVtw value using the logistic algorithm, achieves a balanced sensitivity and specificity of 81.4% and 94.1%, respectively. Subsequently, the 3D-MCI is computed as follows: 7.650\u20130.367*GLS (%) - 0.281*LVtw (\u00b0). Furthermore, the 3D-MCI exhibited a strong significant correlation with both the primary endpoint and the secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>3D-STI technology may facilitate the early detection of cardiac injury in individuals with cSLE, whereas 3D-MCI serves as suitable prognostic indicators for cSLE patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1510852","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:21:50Z","timestamp":1744176110000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Three-dimensional speckle-tracking imaging for the prognosis of childhood-onset systemic lupus erythematosus: a pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoyuan","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/S0140-6736(23)00457-9","article-title":"Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK","volume":"401","author":"Conrad","year":"2023","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/acr.24827","article-title":"Epidemiology of childhood-onset systemic lupus erythematosus: a population-based study","volume":"74","author":"Valenzuela-Almada","year":"2022","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s40272-021-00457-z","article-title":"An update on the management of childhood-onset systemic lupus erythematosus","volume":"23","author":"Trindade","year":"2021","journal-title":"Paediatr Drugs"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1128754","DOI":"10.3389\/fimmu.2023.1128754","article-title":"Childhood-onset systemic lupus erythematosus: characteristics and the prospect of glucocorticoid pulse therapy","volume":"14","author":"Pan","year":"2023","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1177\/00033197221078056","article-title":"Cardiovascular manifestations, imaging, and outcomes in systemic lupus erythematosus: an eight-year single center experience in the United States","volume":"73","author":"Ming","year":"2022","journal-title":"Angiology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3899\/jrheum.130874","article-title":"Mortality and cardiovascular burden of systemic lupus erythematosus in a US population-based cohort","volume":"41","author":"Bartels","year":"2014","journal-title":"J Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1177\/09612033221106581","article-title":"Subclinical systolic dysfunction by speckle tracking echocardiography in patients with systemic lupus erythematosus","volume":"31","author":"Azpiri-Lopez","year":"2022","journal-title":"Lupus"},{"key":"B8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ijcard.2023.05.019","article-title":"Cardiac involvement in systemic lupus erythematosus: can we do better?","volume":"386","author":"Bourg","year":"2023","journal-title":"Int J Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1186\/s12885-023-11261-y","article-title":"3D-based strain analysis and cardiotoxicity detection in cancer patients received chemotherapy","volume":"23","author":"Azzam","year":"2023","journal-title":"Bmc Cancer"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1111\/echo.14467","article-title":"Early detection of cardiotoxicity by 3D speckle tracking imaging of area strain in breast cancer patients receiving chemotherapy","volume":"36","author":"Chen","year":"2019","journal-title":"Echocardiography"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1111\/echo.15189","article-title":"Speckle tracking imaging combined with myocardial comprehensive index to evaluate left ventricular function changes in patients with systemic lupus erythematosus","volume":"38","author":"Feng","year":"2021","journal-title":"Echocardiography"},{"key":"B12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3760\/cma.j.issn.0578-1310.2009.07.003","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0\u201318 years","volume":"47","author":"Li","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"B13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3760\/cma.j.issn.0578-1310.2010.09.013","article-title":"Evidence-based guidelines for diagnosis and treatment of common renal diseases in children (for trial) (VI): guidelines for the diagnosis and treatment of lupus nephritis","volume":"48","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"B14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11926-021-00985-0","article-title":"Systemic lupus erythematosus in children and young people","volume":"23","author":"Charras","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"keae344","DOI":"10.1093\/rheumatology\/keae344","article-title":"Long-term outcomes of childhood-onset systemic lupus erythematosus","author":"Mirguet","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/art.40697","article-title":"Long-term clinical outcomes in a cohort of adults with childhood-onset systemic lupus erythematosus","volume":"71","author":"Groot","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.21037\/apm-20-1074","article-title":"3D-STI evaluation of the effect of dexrazoxane on the mechanical properties of right ventricular myocardium in breast cancer patients treated with pirarubicin","volume":"9","author":"Wang","year":"2020","journal-title":"Ann Palliat Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/jcu.22941","article-title":"Changes in left ventricular function induced by carboplatin combined with paclitaxel in patients with ovarian cancer identified using three-dimensional spot tracking imaging technology","volume":"49","author":"Zhai","year":"2021","journal-title":"J Clin Ultrasound"},{"key":"B19","doi-asserted-by":"publisher","first-page":"942620","DOI":"10.3389\/fcvm.2022.942620","article-title":"A global case meta-analysis of three-dimensional speckle tracking for evaluating the cardiotoxicity of anthracycline chemotherapy in breast cancer","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1159\/000531711","article-title":"Left ventricular function in patients on maintenance hemodialysis: a three-dimensional speckle-tracking imaging study","volume":"13","author":"Chen","year":"2023","journal-title":"Cardiorenal Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"321","DOI":"10.21470\/1678-9741-2020-0455","article-title":"Evaluation of left ventricular systolic function in patients with coronary microvascular dysfunction by three-dimensional speckle-tracking imaging","volume":"37","author":"Yu","year":"2022","journal-title":"Braz J Cardiovasc Surg"},{"key":"B22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/ped.13521","article-title":"Cardiac function on 3-D speckle tracking imaging and cytokines in Kawasaki disease","volume":"60","author":"Kato","year":"2018","journal-title":"Pediatr Int"},{"key":"B23","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s11845-018-1934-7","article-title":"Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study","volume":"188","author":"Jia","year":"2019","journal-title":"Ir J Med Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.jacc.2016.12.012","article-title":"A test in context: myocardial strain measured by speckle-tracking echocardiography","volume":"69","author":"Collier","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s10067-016-3289-7","article-title":"Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography","volume":"35","author":"Dedeoglu","year":"2016","journal-title":"Clin Rheumatol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1510852\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:21:53Z","timestamp":1744176113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1510852\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":25,"alternative-id":["10.3389\/fped.2025.1510852"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1510852","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"article-number":"1510852"}}