{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:24Z","timestamp":1753891944749,"version":"3.41.2"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To understand the status of vitamin D deficiency in girls with growth and developmental variations, as well as the impact of COVID\u221219 on their vitamin D levels, and to provide reference for the prevention and treatment of vitamin D deficiency in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 1,345 instances of girls with growth and developmental variations who visited our pediatric endocrinology department and completed vitamin D detection. A total of 279 girls with complete data were included in this study. Among them, 246 girls were classified into four groups based on different growth and developmental variations: early puberty group, menarche group, obesity group, short stature group, and 33 healthy girls served as the control group. Besides, the girls were divided into pre-epidemic and post-epidemic groups by the occurrence of the COVID-19 epidemic. Vitamin D were measured in all girls. The 25(OH)D &amp;lt;20\u2005ng\/ml was used as the standard for vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of vitamin D in the early puberty group, menarche group, obesity group, short stature group, and control group were as follows: 20.23\u2009\u00b1\u20095.90\u2005ng\/ml, 17.85\u2009\u00b1\u20095.69\u2005ng\/ml, 21.31\u2009\u00b1\u20098.99\u2005ng\/ml, 27.90\u2009\u00b1\u200912.27\u2005ng\/ml, and 29.42\u2009\u00b1\u200912.65\u2005ng\/ml, respectively. The levels of vitamin D in the early puberty group, menarche group, and obesity group were significantly lower than those in the control group (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). The individual vitamin D deficiency rates in the aforementioned groups were 52.07%, 73.91%, 59.46%, 30.95%, and 30.30%, respectively. The vitamin D levels in the pre-epidemic and post-epidemic groups were 20.48\u2009\u00b1\u20096.22\u2005ng\/ml and 22.50\u2009\u00b1\u20099.74\u2005ng\/ml, respectively (<jats:italic>P<\/jats:italic>\u2009&amp;gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Girls with early puberty, menarche, and obesity have a certain deficiency of vitamin D levels, and appropriate vitamin D treatment should be provided clinically. Girls with short stature and healthy girls also have certain levels of vitamin D deficiency, and awareness of prevention should be strengthened.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1518548","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T06:45:31Z","timestamp":1737960331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of vitamin D deficiency in girls with growth and development variations\u2014a single center 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