{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:12:27Z","timestamp":1788541947940,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"publisher","award":["Grant number MED-345-2023"],"award-info":[{"award-number":["Grant number MED-345-2023"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perinatal asphyxia (PA) is a critical neonatal condition and a leading cause of morbidity and mortality, particularly in low- and middle-income countries. Despite its clinical relevance, data on the prevalence and risk factors for PA in Colombia remain limited. This study aimed to estimate the cumulative prevalence of PA and identify associated risk factors in the Colombian neonatal population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines. A comprehensive search of PubMed, Scopus, LILACS, and Web of Science databases was performed between July and August 2024. No restrictions were applied regarding the publication year. Data were extracted, synthesized, and analyzed using random-effects models. Heterogeneity was assessed using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and \u03c4\n                      <jats:sup>2<\/jats:sup>\n                      statistics, and potential publication bias was evaluated using Funnel Plot analysis and Egger's test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine studies with 16,778 patients were included. The cumulative prevalence of PA was estimated to be 5.92% (95% CI: 0.00, 25.03%) with significant heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200999.2%). Key risk factors associated with PA included meconium-stained amniotic fluid (pooled OR 7.5; 95% CI 1.4\u201339.6), prolonged second stage of labor (pooled OR 15.1; 95% CI 1.4\u2013157.6), and intrapartum fetal distress (pooled OR 11.6; 95% CI 1.2\u2013114.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings revealed a notable burden of PA in Colombia and highlighted critical inconsistencies in the diagnostic criteria and reporting practices across studies. These results underscore the urgent need to standardize definitions, strengthen perinatal surveillance systems, and improve obstetric and neonatal care. By identifying major evidence gaps and the most consistent risk factors, this review provides a foundation for future multicenter research and for the development of targeted evidence-based interventions to reduce preventable neonatal morbidity and mortality in Colombia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1534397","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:33:09Z","timestamp":1764829989000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and risk factors of perinatal asphyxia in newborns in Colombia: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Sergio","family":"Agudelo-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mej\u00eda Echeverr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Valentina","family":"Medell\u00edn Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Dayana","family":"Garc\u00eda C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"P\u00e9rez Fl\u00f3rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"B1","volume-title":"Guidelines on Basic Newborn Resuscitation","year":"2012"},{"key":"B2","first-page":"1","article-title":"Neonatal Encephalopathy and Neurologic Outcome","year":"2014"},{"key":"B3","first-page":"1","article-title":"Levels & Trends in Child Mortality Report 2019","year":"2019"},{"key":"B4","doi-asserted-by":"publisher","first-page":"280.e1","DOI":"10.1016\/j.anpedi.2022.08.006","article-title":"Neonatal multiple organ failure after perinatal asphyxia","volume":"97","author":"Iribarren","year":"2022","journal-title":"An Pediatr (Engl Ed)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1478-4505-5-4","article-title":"Reducing one million child deaths from birth asphyxia\u2014a survey of health systems gaps and priorities","volume":"5","author":"Lawn","year":"2007","journal-title":"Health Res Policy Syst"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0264816","DOI":"10.1371\/journal.pone.0264816","article-title":"The magnitude of neonatal asphyxia and its associated factors among newborns in public hospitals of north Gondar zone, northwest Ethiopia: a cross-sectional study","volume":"17","author":"Admasu","year":"2022","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fped.2019.00489","article-title":"A global view of neonatal asphyxia and resuscitation","volume":"7","author":"Moshiro","year":"2019","journal-title":"Front Pediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"04030","DOI":"10.7189\/JOGH.12.04030","article-title":"Therapeutic hypothermia in neonatal hypoxic encephalopathy: a systematic review and meta-analysis","volume":"12","author":"Mathew","year":"2022","journal-title":"J Glob Health"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e","DOI":"10.18041\/2665-427x\/ijeph.2.5286","article-title":"Frecuencia y determinantes de la asfixia perinatal en un servicio especializado de popay\u00e1n Colombia 2014","volume":"1","author":"S\u00e1nchez","year":"2018","journal-title":"Interdiscip J Epidemiol Public Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.21518\/2079-701X-2022-16-19-21-28","article-title":"Risk factors for birth asphyxia","volume":"2022","author":"Taranushenko","year":"2022","journal-title":"Meditsinskiy Sovet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2147\/phmt.s260788","article-title":"Risk factors of perinatal asphyxia among newborns delivered at public hospitals in Addis Ababa, Ethiopia: case\u2013control study","volume":"11","author":"Mulugeta","year":"2020","journal-title":"Pediatric Health Med Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.15562\/ijbs.v17i1.446","article-title":"Factors associated with the incidence of perinatal asphyxia at sanjiwani regional general hospital, Gianyar, Bali, Indonesia","volume":"17","author":"Pradnyaswari","year":"2023","journal-title":"Indonesia J Biomed Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1159\/000538986","article-title":"Brain MRI injury patterns across gestational age among preterm infants with perinatal asphyxia","volume":"121","author":"Parmentier","year":"2024","journal-title":"Neonatology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.37757\/MR2021.V23.N1.7","article-title":"Hypoxic ischemic encephalopathy in units reporting to the ibero-American society of neonatology network: prevalence and mortality","volume":"23","author":"Dominguez-Dieppa","year":"2021","journal-title":"MEDICC Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.24245\/gom.v92i6.9748","article-title":"Perinatal asphyxia: antepartum and intrapartum characteristics in a second-level hospital","volume":"92","author":"Moreno","year":"2024","journal-title":"Ginecol Obstet Mex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.rprh.2016.06.009","article-title":"Factores asociados a asfixia perinatal en un hospital de Callao, Per\u00fa","volume":"30","author":"Romero","year":"2016","journal-title":"Perinatol Reprod Hum"},{"key":"B17","volume-title":"Informe de Evento Mortalidad Perinatal y Neonatal Tard\u00eda, Colombia, 2020","author":"Forero","year":"2020"},{"key":"B18","article-title":"Prevalence of Perinatal Asphixia in Newborns at the Erasmo Meoz De C\u00facuta University Hospital in 2021","author":"Luis","year":"2021"},{"key":"B19","article-title":"Modelo de vigilancia de la morbilidad neonatal extrema y primer an\u00e1lisis agregado de casos","year":"2014"},{"key":"B20","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann Intern Med"},{"key":"B21","volume-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses","author":"Wells","year":""},{"key":"B22","first-page":"132","article-title":"Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach.","volume-title":"Int J Evid Based Healthc","author":"Aromataris","year":"2015"},{"key":"B23","first-page":"1","article-title":"Prevalencia de asfixia perinatal en reci\u00e9n nacidos en el hospital universitario erasmo meoz de c\u00facuta en el a\u00f1o 2021","volume":"6","author":"Moncada","year":"2022","journal-title":"Revista Sinergia Hospital Universitario Erasmo Meoz"},{"key":"B24","doi-asserted-by":"publisher","first-page":"332","DOI":"10.15446\/rsap.v19n3.65204","article-title":"Hipoxia perinatal en el hospital mederi de bogot\u00e1: comportamiento en los a\u00f1os 2007 a 2011","volume":"19","author":"Del Riesgo-Prendes","year":"2017","journal-title":"Revista de Salud P\u00fablica"},{"key":"B25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.rprh.2018.07.001","article-title":"Descripci\u00f3n de una cohorte de pacientes neonatos con diagn\u00f3stico de asfixia perinatal, tratados con hipotermia terap\u00e9utica. 2017","volume":"32","author":"Manotas","year":"2018","journal-title":"Perinatol Reprod Hum"},{"key":"B26","first-page":"2","article-title":"Caracterizaci\u00f3n de los reci\u00e9n nacidos con asfixia perinatal en un hospital universitario de tercer nivel en Colombia","volume":"15","author":"Torres","year":"2013","journal-title":"Revista Gastrohnup"},{"key":"B27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.12804\/revistas.urosario.edu.co\/revsalud\/a.6118","article-title":"Fatores de risco associados a asfixia perinatal no hospital universit\u00e1rio m\u00e9deri, 2010\u20132011","volume":"15","author":"Rinc\u00f3n Socha","year":"2017","journal-title":"Revista Ciencias de la Salud"},{"key":"B28","first-page":"58","article-title":"Factores de riesgo asociados a asfixia perinatal. UCIN camino universitario distrital adelita de char. Barranquilla, periodo enero a diciembre de 2015","volume":"35","author":"P\u00e9rez","year":"2017","journal-title":"Revista Unimetro"},{"key":"B29","doi-asserted-by":"publisher","first-page":"535737","DOI":"10.3389\/fpubh.2021.535737","article-title":"Biological and psychosocial factors, risk behaviors, and perinatal asphyxia in a university hospital: matched case\u2013control study, Cali, Colombia (2012\u20132014)","volume":"9","author":"Torres-Mu\u00f1oz","year":"2021","journal-title":"Front Public Health"},{"key":"B30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.7705\/biomedica.v37i1.2844","article-title":"Risk factors associated with the development of perinatal asphyxia in neonates at hospital universitario del Valle, Cali, Colombia, 2010\u20132011","volume":"37","author":"Torres-Mu\u00f1oz","year":"2017","journal-title":"Biom\u00e9dica"},{"key":"B31","volume-title":"Birth Asphyxia\u2014statPearls\u2014nCBI Bookshelf.","author":"Kraukauer-Gillian","year":"2023"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1016\/S0140-6736(17)32162-1","article-title":"Changes in cause-specific neonatal and 1\u201359-month child mortality in India from 2000 to 2015: a nationally representative survey","volume":"390","author":"Fadel","year":"2017","journal-title":"Lancet"},{"key":"B33","first-page":"1","article-title":"Mortalidad perinatal y neonatal tard\u00eda, periodo epidemiol\u00f3gico I, Colombia 2021. Bogot\u00e1","author":"Forero","year":"2021"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0255488","DOI":"10.1371\/journal.pone.0255488","article-title":"Prevalence and risk factors associated with birth asphyxia among neonates delivered in Ethiopia: a systematic review and metaanalysis","volume":"16","author":"Ahmed","year":"2021","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12887-020-02039-3","article-title":"Perinatal asphyxia and its associated factors in Ethiopia: a systematic review and meta-analysis","volume":"20","author":"Sendeku","year":"2020","journal-title":"BMC Pediatr"},{"key":"B36","first-page":"35","article-title":"Determinants of birth asphyxia among newborns in Ethiopia: a systematic review and meta-analysis","volume":"14","author":"Desalew","year":"2020","journal-title":"Int J Health Sci (Qassim)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e03793","DOI":"10.1016\/j.heliyon.2020.e03793","article-title":"Prevalence of perinatal asphyxia in east and Central Africa: systematic review and meta-analysis","volume":"6","author":"Workineh","year":"2020","journal-title":"Heliyon"},{"key":"B38","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.jped.2016.11.008","article-title":"Early neonatal deaths associated with perinatal asphyxia in infants \u22652500\u2005g in Brazil","volume":"93","author":"de Almeida","year":"2017","journal-title":"J Pediatr (Rio J)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1186\/s12889-016-3238-z","article-title":"An analysis of three levels of scaled-up coverage for 28 interventions to avert stillbirths and maternal, newborn and child mortality in 27 countries in Latin America and the Caribbean with the lives saved tool (LiST)","volume":"16","author":"Arnesen","year":"2016","journal-title":"BMC Public Health"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2024-018526","article-title":"Socioeconomic inequalities in infant mortality in Colombia: a nationwide cohort study during 10 years","author":"Buitrago","year":"2025","journal-title":"BMJ Glob Health"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1534397\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:33:11Z","timestamp":1764829991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1534397\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":40,"alternative-id":["10.3389\/fped.2025.1534397"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1534397","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"article-number":"1534397"}}