{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:39:48Z","timestamp":1782520788013,"version":"3.54.5"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sputum retention in pediatric pneumonia hinders recovery. This study evaluated the therapeutic benefits of incorporating mechanical vibration-assisted sputum clearance (MVSC) as an adjunct to standard pharmacological treatment and developed a nomogram to optimize treatment parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized controlled trial, 160 children with pneumonia were randomly assigned (1:1) to a control group receiving pharmacological treatment or a treatment group receiving additional mechanical vibration therapy. The proportion of patients showing clinical improvement (defined as \u201cmarkedly improved\u201d or \u201cimproved\u201d) was assessed, along with symptom resolution times, lung function, blood gas parameters, and inflammatory markers, which were measured at baseline and treatment completion. LASSO regression identified predictors of clinical improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significantly greater proportion of patients exhibited clinical improvement in the treatment group (93.75%) compared to the control group (75%, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). The treatment group also showed significantly shorter times for symptom resolution (pulmonary rales, fever, and cough) and hospital stay (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). Improvements in lung function (FEV1, FEV1\/FVC), blood gas parameters (PaO\u2082, PaCO\u2082, pH), and greater reductions in inflammatory markers (CRP, PCT), were observed in the treatment group (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). A nomogram was developed using age, chest circumference, moist rales, disease severity, vibration frequency, and pressure to determine optimal mechanical vibration settings for individualized treatment. The nomogram showed high predictive accuracy (AUC\u2009=\u20090.943) in estimating clinical improvement, aiding in the optimization of MVSC in pediatric pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MVSC enhances the treatment of pediatric pneumonia, with the nomogram optimizing the parameters of the sputum clearance device.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1539218","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:28:26Z","timestamp":1750915706000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of mechanical vibration-assisted sputum clearance in pediatric pneumonia: a randomized controlled trial with development of an intelligent parameter optimization model"],"prefix":"10.3389","volume":"13","author":[{"given":"Sujing","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ledan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"j2739","DOI":"10.1136\/bmj.j2739","article-title":"Advances in the diagnosis of pneumonia in children","volume":"358","author":"Zar","year":"2017","journal-title":"BMJ (Clin Res Ed)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.prrv.2020.06.007","article-title":"Rational use of mucoactive medications to treat pediatric airway disease","volume":"36","author":"Linssen","year":"2020","journal-title":"Paediatr Respir Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"544826","DOI":"10.3389\/fmed.2021.544826","article-title":"Airway clearance techniques: the right choice for the right patient","volume":"8","author":"Belli","year":"2021","journal-title":"Front Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1055\/s-0035-1563385","article-title":"Chest physiotherapy in the pediatric intensive care unit","volume":"4","author":"Morrow","year":"2015","journal-title":"J Pediatr Intensive Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.21037\/tp-20-237","article-title":"The effect of vibrating positive expiratory pressure therapy on refractory Mycoplasma pneumoniae pneumonia prognosis in children","volume":"10","author":"Sun","year":"2021","journal-title":"Transl Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1513\/AnnalsATS.202005-482OC","article-title":"The use of airway clearance devices in the management of chronic obstructive pulmonary disease. 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