{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:03:40Z","timestamp":1767971020188,"version":"3.49.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to report a case of tracheobronchial ossification (TO) in a child and review the related literature on its clinical signs, diagnosis, differential diagnosis, pathological characteristics, points, and treatment measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on the clinical data of one pediatric patient with TO admitted to the Department of Pediatrics, Fuzhou Pulmonary Hospital. In addition, three relevant articles published up to July 2024 were reviewed from both domestic and international databases, including PubMed, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Biomedical Literature Database (CBM), Web of Science, and the Cochrane Library. The clinical features of a total of four pediatric cases of tracheobronchial osteochondroplasia were summarized and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 12-year-old girl with a 5-year history of symptoms was retrospectively reviewed. The patient presented with chronic cough, sputum, hemoptysis, and exertional dyspnea. Comorbidities such as bronchiectasis with cavitation, pneumonia, <jats:italic>Klebsiella pneumoniae<\/jats:italic> infection, and sinusitis were observed. Imaging revealed airway wall nodules and structural lung changes. Bronchoscopy showed scattered white nodules; histopathology confirmed mucosal ossification with focal bone marrow formation. Symptomatic improvement was achieved after anti-infective and supportive treatment. A 4-year follow-up revealed recurrent pneumonia and progression of bronchiectasis. Three additional pediatric TO cases (aged 6 months to 9 years) were identified in the literature. Presentations included respiratory symptoms and recurrent infections. Pulmonary function abnormalities, typical radiological and bronchoscopic features, and histopathological evidence were variably reported. Treatments ranged from symptomatic therapy to bronchoscopic intervention. One patient died, one remained stable, and follow-up data were limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TO can develop in children, with atypical chest computed tomography and bronchoscopic changes. Histopathological examination can confirm the diagnosis, and symptomatic treatment is the mainstay.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1552947","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:13:33Z","timestamp":1747887213000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Tracheobronchial ossification in children: a case report and review of the literature"],"prefix":"10.3389","volume":"13","author":[{"given":"Yan","family":"Ruan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","first-page":"220","article-title":"A case report of tracheobronchial osteochondroplasia in a child","volume":"9","author":"Ma","year":"2014","journal-title":"Chin J Evid Based Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s13312-012-0223-1","article-title":"Tracheobronchopathia osteochondroplastica in a 5 year-old girl","volume":"49","author":"Sant\u2019Anna","year":"2012","journal-title":"Indian Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/ppul.20311","article-title":"Tracheobronchopathia osteochondroplastica in a 9-year-old girl","volume":"41","author":"Simsek","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s004280050111","article-title":"Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica","volume":"431","author":"Tajima","year":"1997","journal-title":"Virchows Arch"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41467-022-28903-7","article-title":"Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica","volume":"13","author":"Hong","year":"2022","journal-title":"Nat Commun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.2147\/IJGM.S418394","article-title":"Clinical characteristics of tracheobronchopathia osteochondroplastica: a retrospective study of 33 patients","volume":"16","author":"Liu","year":"2023","journal-title":"Int J Gen Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/LBR.0000000000000931","article-title":"Tracheobronchopathia osteochondroplastica\u2014to biopsy or not to biopsy? A relook at the rare disease","volume":"31","author":"Nair","year":"2024","journal-title":"J Bronchology Interv Pulmonol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1055\/s-2002-25305","article-title":"Tracheobronchopathia osteochondroplastica","volume":"23","author":"Prakash","year":"2002","journal-title":"Semin Respir Crit Care Med"},{"key":"B9","first-page":"178","article-title":"A case of tracheobronchopathia osteochondroplastica and literature review","volume":"24","author":"Li","year":"2019","journal-title":"J Clin Pulmonol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00408-008-9088-4","article-title":"Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature","volume":"186","author":"Jabbardarjani","year":"2008","journal-title":"Lung"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e419","DOI":"10.1016\/j.athoracsur.2019.09.014","article-title":"Bronchoscopic surgery for a solitary tracheal tumor of tracheobronchopathia osteochondroplastica","volume":"109","author":"Sakaguchi","year":"2020","journal-title":"Ann Thorac Surg"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1552947\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:13:34Z","timestamp":1747887214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1552947\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":11,"alternative-id":["10.3389\/fped.2025.1552947"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1552947","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"article-number":"1552947"}}