{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:15:02Z","timestamp":1760382902436,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Preterm infants have well-documented deficiencies in their innate and adaptive immune responses, which are indirectly correlated with their gestational age at birth. They also exhibit low levels of circulating immunoglobulins due to the lack of maternal transplacental IgG transfer during the third trimester of pregnancy. These factors place them at a particularly high risk for infectious diseases after birth. Diagnosing infections that primarily manifest through abnormal skin findings can be challenging, given overlapping characteristics attributed to bacterial and yeast pathogens. The case presented involves an infant born extremely premature with staphylococcal scalded skin syndrome (SSSS), a diagnosis rarely made in neonatal patients. However, he was initially treated for a yeast infection of his neck and skin folds, which is very common. This patient's course was complicated by a family history concerning for an undiagnosed, inherited immune deficiency. This case highlights the clinical findings and management of SSSS in preterm infants. It also details the importance of establishing a specialized multidisciplinary team to coordinate and manage the care of these patients.<\/jats:p>","DOI":"10.3389\/fped.2025.1564633","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:18:54Z","timestamp":1742195934000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Delayed recurrence of staphylococcal scalded skin syndrome in an extremely low birth weight infant"],"prefix":"10.3389","volume":"13","author":[{"given":"Sara M.","family":"Hooper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille M.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Torr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley M.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antibiotics12040632","article-title":"Staphylococcal infections and neonatal skin: data from literature and suggestions for the clinical management from four challenging patients","volume":"12","author":"De Rose","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00431-014-2414-3","article-title":"Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants","volume":"174","author":"Saida","year":"2015","journal-title":"Eur J Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/pde.14014","article-title":"Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome","volume":"37","author":"Wang","year":"2020","journal-title":"Pediatr Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/bjd.16097","article-title":"Epidemiology of staphylococcal scalded skin syndrome in U.S. children","volume":"178","author":"Staiman","year":"2018","journal-title":"Br J Dermatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jaad.2017.09.023","article-title":"Epidemiology of staphylococcal scalded skin syndrome in the United States: a cross-sectional study, 2010\u20132014","volume":"78","author":"Arnold","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/s0140-6736(99)90120-4","article-title":"Staphylococcal scalded-skin syndrome","volume":"354","author":"Farrell","year":"1999","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1128\/jcm.43.4.1890-1893.2005","article-title":"Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins","volume":"43","author":"Yamasaki","year":"2005","journal-title":"J Clin Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/81385","article-title":"Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1","volume":"6","author":"Amagai","year":"2000","journal-title":"Nat Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/anc.0000000000000979","article-title":"Staphylococcal scalded skin syndrome, identification, and wound care: a case report series","volume":"22","author":"McKeown","year":"2022","journal-title":"Adv Neonatal Care"},{"key":"B10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1891\/0730-0832.35.1.8","article-title":"Staphylococcal scalded skin syndrome: a case review","volume":"35","author":"Hennigan","year":"2016","journal-title":"Neonatal Netw"},{"key":"B11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s12519-018-0150-x","article-title":"Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management","volume":"14","author":"Leung","year":"2018","journal-title":"World J Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1440-1754.2008.01316.x","article-title":"Staphylococcal scalded skin syndrome in an extremely premature neonate: a case report with a brief review of literature","volume":"44","author":"Kapoor","year":"2008","journal-title":"J Paediatr Child Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.18590\/mjm.2016.vol2.iss1.6","article-title":"Case report: recurrent staphylococcal scalded skin syndrome in healthy term neonate despite full course of antibiotic therapy","volume":"2","author":"Bhavsar","year":"2016","journal-title":"Marshall J Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"7313","DOI":"10.4076\/1752-1947-3-7313","article-title":"Recurring staphylococcal scalded skin syndrome in a very low birth weight infant: a case report","volume":"3","author":"Duijsters","year":"2009","journal-title":"J Med Case Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e134","DOI":"10.1055\/s-0037-1603971","article-title":"Recurrent staphylococcal scalded skin syndrome in an extremely low-birth-weight neonate","volume":"7","author":"Davidson","year":"2017","journal-title":"AJP Rep"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1564633\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:18:56Z","timestamp":1742195936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1564633\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":15,"alternative-id":["10.3389\/fped.2025.1564633"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1564633","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"article-number":"1564633"}}