{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:09Z","timestamp":1753891869536,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the correlation between the quantitative analysis curve of renal contrast-enhanced ultrasound and the anatomical location of renal cortical microcirculation associated with acute kidney injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included a 1-year-and-11-month-old female child with acute kidney injury caused by drug overdosed and a 14-year-old female child with acute kidney injury caused by drug intentional, who were treated at Shanghai Children's Medical Center affiliated with Shanghai Jiao Tong University School of Medicine. Both patients underwent renal contrast-enhanced ultrasound and quantitative analysis. In addition, their clinical medical history data were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first child developed acute kidney injury owing to cyclosporine A overdosed. Contrast-enhanced ultrasound revealed poor cortical blood flow perfusion in both kidneys, with abnormally prolonged cortical perfusion times and possible obstruction of vascular inflow pathways. The second child experienced acute kidney injury owing to ibuprofen intentional. Contrast-enhanced ultrasound showed good cortical blood wash-in\/perfusion but significantly delayed wash-out\/excretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The structure and function of the glomerulus significantly influence the perfusion rate and intensity of the rising branch of the curve. Furthermore, the descending branch of the curve is affected by the interplay of the capillaries surrounding the renal tubules. Exploration of these anatomical structures aids in understanding the renal microcirculation pathways and provides further insight into renal perfusion dynamics.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1574398","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:50:38Z","timestamp":1749793838000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of renal contrast-enhanced ultrasound to explore renal cortical microcirculation abnormalities in pediatric acute kidney injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Chunbei","family":"Yi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s40001-024-01704-y","article-title":"Ultrasonographic assessment of renal microcirculation is a new vision for the treatment of intensive care unit associated acute kidney injury","volume":"29","author":"Chen","year":"2024","journal-title":"Eur J Med Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.14366\/usg.19022","article-title":"General principles and overview of vascular contrast-enhanced ultrasonography","volume":"39","author":"Rafailidis","year":"2020","journal-title":"Ultrasonography"},{"key":"B3","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s00261-018-1516-1","article-title":"Imaging with ultrasound contrast agents: current status and future","volume":"43","author":"Chong","year":"2018","journal-title":"Abdom Radiol (NY)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1053\/j.akdh.2022.12.003","article-title":"Targeting glomerular hemodynamics for kidney protection","volume":"30","author":"Savedchuk","year":"2023","journal-title":"Adv Kidney Dis Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0896-8411(92)90053-S","article-title":"The effect of cyclosporin on renal function","volume":"5","author":"Mason","year":"1992","journal-title":"J Autoimmun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1681\/ASN.V48s17","article-title":"Renal function in patients receiving long-term cyclosporine therapy","volume":"4","author":"Van Buren","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1179\/174329211X12968219310837","article-title":"Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats","volume":"16","author":"Abraham","year":"2011","journal-title":"Redox Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.cca.2006.04.006","article-title":"Normal plasma creatinine level despite histological evidence of damage and increased oxidative stress in the kidneys of cyclophosphamide treated rats","volume":"376","author":"Sugumar","year":"2007","journal-title":"Clin Chim Acta"},{"key":"B9","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3109\/0886022X.2012.655683","article-title":"Biopsy-proven acute tubular necrosis associated with vancomycin in an adult patient","volume":"34","author":"Belen","year":"2012","journal-title":"Ren Fail"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1007\/s00467-002-0989-9","article-title":"Prospective study of renal insufffciency after bone marrow transplantation","volume":"17","author":"Kist-van Holthe","year":"2002","journal-title":"Pediatr. 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