{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:21:53Z","timestamp":1775064113534,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the diagnosis, treatment, and prognosis of children with pancreatic tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of patients \u226418 years of age with pancreatic neoplasms who underwent surgery at a single institution between 2010 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common histology among the 48 patients was solid pseudopapillary neoplasm of the pancreas (SPN, <jats:italic>n<\/jats:italic>\u2009=\u200932), followed by pancreatic blastoma (PB, <jats:italic>n<\/jats:italic>\u2009=\u200912), B-cell lymphoblastic lymphoma (<jats:italic>n<\/jats:italic>\u2009=\u20091), leukaemia (<jats:italic>n<\/jats:italic>\u2009=\u20091), pancreatic cancer (<jats:italic>n<\/jats:italic>\u2009=\u20091), and pancreatic neuroendocrine tumours (<jats:italic>n<\/jats:italic>\u2009=\u20091). The tumours were located in the head of the pancreas in 29 patients (10 patients underwent pancreaticoduodenectomy, 9 patients underwent Whipple, 7 patients underwent pancreatic tumour resection, and 3 patients underwent laparoscopic tumour enucleation). The tumours were located in the tail of the pancreatic body in 19 patients (10 patients underwent local resection of the pancreatic tumour, 5 patients underwent resection of the pancreatic body and tail and spleen, 3 patients underwent spleen-preserving distal pancreatectomy, and 1 patient underwent laparoscopic resection of the tumour). Patients with pancreatoblastoma, acute lymphoblastic leukaemia, B lymphoblastic lymphoma or pancreatic cancer were treated with regular chemotherapy. Forty-five patients (93.75%) were currently alive and disease free, and the median follow-up was 8.2 years (IQR: 2.0\u201314.3). Two patients with pancreatic blastoma died during the follow-up, and 1 patient with pancreatic cancer died due to tumour recurrence and progression after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Paediatric pancreatic tumours are highly heterogeneous. Complete surgical resection that preserves organ function is the preferred treatment for children with pancreatic tumours.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1576273","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T05:21:29Z","timestamp":1749705689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical diagnosis, treatment and prognosis analysis of children with pancreatic 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