{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:22:06Z","timestamp":1780100526165,"version":"3.54.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Thiamine is an essential micronutrient, and its deficiency, also known as beriberi, can have significant clinical implications. Thiamine deficiency impairs oxidative metabolic pathways, leading to reduced adenosine triphosphate (ATP) synthesis and energy production. This deficiency primarily affects energy-demanding organs, such as the brain and heart, resulting in central and peripheral neuropathies, severe metabolic acidosis, or even circulatory failure. Due to its nonspecific clinical presentation, thiamine deficiency is often misdiagnosed or overlooked, making early recognition and intervention critical for improving outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>This report describes a case of shoshin beriberi with concurrent neurological involvement caused by thiamine deficiency following intestinal surgery. Remarkably, the patient's condition improved significantly with timely thiamine supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In individuals at high risk of thiamine deficiency, such as those with prolonged fasting, gastrointestinal disorders, or chronic malnutrition, early identification and timely intervention are crucial for improving prognosis and reducing mortality. Early recognition and treatment are critical to reducing mortality associated with this condition.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1576805","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:16:52Z","timestamp":1748236612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thiamine deficiency secondary to intestinal surgery leading to shoshin beriberi and Wernicke encephalopathy: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Peiyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.amjms.2018.06.015","article-title":"Thiamine deficiency: an important consideration in critically ill patients","volume":"356","author":"Attaluri","year":"2018","journal-title":"Am J Med Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"447129","DOI":"10.3389\/fpsyt.2019.00207","article-title":"Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults","volume":"10","author":"Dhir","year":"2019","journal-title":"Front Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.3390\/cells10102595","article-title":"Hiding in plain sight: modern thiamine deficiency","volume":"10","author":"Marrs","year":"2021","journal-title":"Cells"},{"key":"B4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4070\/kcj.2013.43.8.569","article-title":"A case of cardiac beriberi: a forgotten but memorable disease","volume":"43","author":"Lee","year":"2013","journal-title":"Korean Circ J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/oxfordjournals.alcalc.a044913","article-title":"Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome","volume":"24","author":"Butterworth","year":"1989","journal-title":"Alcohol Alcohol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e27376","DOI":"10.7759\/cureus.27376","article-title":"Beriberi: a reversible cause of acute severe pulmonary hypertension","volume":"14","author":"Tan","year":"2022","journal-title":"Cureus"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/nyas.13919","article-title":"Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs","volume":"1430","author":"Whitfield","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.36518\/2689-0216.1649","article-title":"Suspected thiamine deficiency secondary to chronic gastrointestinal illness: a case report","volume":"5","author":"Meckley","year":"2024","journal-title":"HCA Healthcare J Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/503596","article-title":"Mr imaging findings in alcoholic and nonalcoholic acute wernicke\u2019s encephalopathy: a review","volume":"2014","author":"Manzo","year":"2014","journal-title":"BioMed Res Int"},{"key":"B10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/nyas.14552","article-title":"The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in northeast India","volume":"1498","author":"Koshy","year":"2021","journal-title":"Ann N Y Acad Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3345\/kjp.2014.57.11.496","article-title":"Wernicke\u2019s encephalopathy in a child with high dose thiamine therapy","volume":"57","author":"Park","year":"2014","journal-title":"Korean J Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s002340050741","article-title":"Do acute lesions of Wernicke\u2019s encephalopathy show contrast enhancement? 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