{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:50:05Z","timestamp":1782953405418,"version":"3.54.5"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lead is a naturally occurring metal with highly toxic effects on humans, particularly children, who are particularly vulnerable to its long-lasting adverse impacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient concerns<\/jats:title><jats:p>This report presents the case of a 10-year-old boy with a 10-month history of recurrent vomiting. No organic lesions were identified. However, the symptoms were inconsistent with cyclic vomiting syndrome (CVS), given the presence of growth retardation, vitamin D deficiency, bilateral cervical lymphadenopathy, academic difficulties, and impaired concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis<\/jats:title><jats:p>Detailed history-taking revealed proximity to a lead mining facility. Blood lead level (BLL) was significantly elevated (382\u2005\u03bcg\/L), confirming chronic lead poisoning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Chelation therapy with dimercaptosuccinic acid (DMSA) was administered for 19 days at a 350\u2005mg\/m<jats:sup>2<\/jats:sup> dose per administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Following treatment, BLL decreased to 168\u2005\u00b5g\/L, accompanied by significant improvement in vomiting and abdominal pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pediatric lead poisoning should be considered in the differential diagnosis of children presenting with cyclic vomiting and neurological symptoms, due to its diagnostic complexity.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1580368","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:12:46Z","timestamp":1754453566000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lead poisoning in a 10-year-old boy with cyclic vomiting as the first symptom: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Liping","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"B1","article-title":"Childhood lead poisoning: clinical manifestations and 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