{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:20:33Z","timestamp":1783941633665,"version":"3.55.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the risk factors associated with renal injury in patients diagnosed with IgA vasculitis at initial presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on the clinical data of 384 children who were newly diagnosed with Immunoglobulin A vasculitis (IgAV) and hospitalized between July 2020 and June 2023. The participants were categorized into two groups based on whether their 24-hour urinary protein levels exceeded 150\u2005mg upon admission. Specifically, those with a 24\u2005h urinary protein level exceeding 150\u2005mg were classified as the IgA vasculitis nephritis (IgAVN), while the remaining participants were included in the IgAV group. A comparative assessment was performed to evaluate the general condition and laboratory examination results of both groups. The logistic regression analysis was utilized to pinpoint variables correlated with renal injury, facilitating the development of a risk prediction model. The receiver operating characteristic curve(ROC) was employed to evaluate the model's predictive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The univariate analysis revealed that the duration of rash, gender, patient age, levels of C-reactive protein(CRP), Immunoglobulin G (IgG), albumin, globulin, glutamic oxaloacetic transaminase(AST), total cholesterol(TC), urine routine results, and 25-(OH)-D<jats:sub>3<\/jats:sub> were all identified as potential influencing factors for IgAVN. Multivariate analysis revealed that albumin, patient age, and TC emerged as independent influential factors in the occurrence of IgAVN. The area under the curve (AUC) for the combined predictor(age\u2009+\u2009albumin\u2009+\u2009TC) was significantly larger than that of individual factors such as age, albumin, and TC, with respective AUC values of 0.804, 0.673, 0.737, and 0.608. The prediction model of IgAVN was further developed as follows: logit(P)\u2009=\u20093.978\u2009+\u20090.199\u2009\u00d7\u2009age (years)\u2009\u2212\u20090.197\u2009\u00d7\u2009albumin (g\/L)\u2009+\u20090.550\u2009\u00d7\u2009TC (mmol\/L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By utilizing certain laboratory indicators, it is possible to enhance the prediction of IgAVN, thereby reinforcing the importance of follow-up measures for early detection, diagnosis, and treatment in order to mitigate the occurrence of unfavorable prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1584768","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T18:26:52Z","timestamp":1753813612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors associated with renal injury in patients initially diagnosed with IgA vasculitis"],"prefix":"10.3389","volume":"13","author":[{"given":"Lu","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12969-017-0146-4","article-title":"A single-center analysis of Henoch-Schonlein purpura nephritis with nephrotic proteinuria in children","volume":"15","author":"Feng","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00431-015-2601-x","article-title":"Beneficial effects of creatine phosphate sodium for the treatment of Henoch-Sch\u00f6nlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels","volume":"175","author":"Zhang","year":"2016","journal-title":"Eur J Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/qjmed\/hcl034","article-title":"Henoch sch\u00f6nlein purpura with nephritis in adults: adverse prognostic indicators in a UK population","volume":"99","author":"Shrestha","year":"2006","journal-title":"QJM"},{"key":"B4","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","article-title":"EULAR\/PRINTO\/PRES criteria for Henoch-Sch\u00f6nlein purpura, childhood polyarteritis nodosa, childhood wegener granulomatosis and childhood takayasu arteritis: Ankara 2008. 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