{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:39:31Z","timestamp":1755225571293,"version":"3.43.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neonates with congenital diaphragmatic hernia (CDH) often present with pulmonary hypertension and various forms of cardiac dysfunction, affecting right or left ventricle or both. Although pulmonary hypertension typically improves over time, some children experience long term pulmonary hypertension. There is limited understanding of cardiac function recovery. The authors hypothesized that cardiac function in the CDH population would remain impaired during the first 2\u20135 weeks of life compared with in a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This prospective observational cohort study included 40 newborns with CDH and 40 controls born in 2021\u20132024 and cared for at Karolinska University Hospital, Stockholm, Sweden. The first study echocardiograms were performed between 6 and 24\u2005h of age. Subsequently, 23 of the 40 CDH cases were also examined at 2\u20135 weeks of age. Left ventricular longitudinal strain (LV LS), right ventricle free wall strain (RVFWS), left atrial reservoir strain (LASr), right atrial reservoir strain (RASr), and conventional echo parameters were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Newborns with CDH had reduced cardiac function measured with LV LS [mean \u221214.7% (standard deviation 4.6) vs. \u221218.8% (2.7), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001], RVFWS [\u221213.9% (4.2) vs. \u221222.4% (4.8) <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001], LASr [22.8% (9.3) vs. 33.9% (8.2), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001], and RASr [21.8% (6.9) vs. 37.6% (9.2), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001], compared with controls. Cardiac strain had improved for all subjects at the age of 2\u20135 weeks. However, the cases with CDH still had lower strain than the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac function measured as strain was reduced in newborns with CDH compared with in a control group. Although their cardiac function improved over time, it remained lower compared to the control group at 2\u20135 weeks of age.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1598695","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:24:51Z","timestamp":1752729891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2\u20135 weeks of age"],"prefix":"10.3389","volume":"13","author":[{"given":"Katarina \u00d6vermo","family":"Tyd\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen 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