{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:07:58Z","timestamp":1775714878241,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mediastinal lesions have diverse etiologies, with thymoma, cystic teratoma, and lymphoma being relatively prevalent. In contrast, a pancreatic pseudocyst within the mediastinum is exceedingly rare and can often be mistaken for a thymic cyst or teratoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 17-year-old female presented with a cough and sputum production. Chest CT revealed an anterior mediastinal mass, initially raising the suspicion of a thymic cyst. Thoracoscopic exploration and resection revealed a cystic lesion with a thick wall and brownish fluid. Both frozen section and final histopathological analysis confirmed a mediastinal cyst. Immunohistochemical markers (SYN positive, CK7 positive) led to a diagnosis of mediastinal pancreatic pseudocyst. The patient experienced significant recovery post-surgery, with a marked improvement in symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the importance of including mediastinal pancreatic pseudocyst in the differential diagnosis of anterior mediastinal cystic lesions. A thorough clinical and radiological assessment, along with surgical pathology and immunohistochemical profiling, is essential for accurate diagnosis and appropriate management.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1613764","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:53:45Z","timestamp":1751435625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["An anterior mediastinal cystic lesion pathologically confirmed as a mediastinal pancreatic pseudocyst after thoracoscopic resection: a rare case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Kui","family":"Zhai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingpeng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiling","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanyu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzhong","family":"Zha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.4240\/wjgs.v16.i7.1986","article-title":"Pancreatic pseudocyst: the past, the present, and the future","volume":"16","author":"Koo","year":"2024","journal-title":"World J Gastrointest Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13256-015-0582-z","article-title":"Pancreatic mediastinal pseudocyst presenting as a posterior mediastinal mass with recurrent pleural effusions: a case report and review of the literature","volume":"9","author":"Karamouzos","year":"2015","journal-title":"J Med Case Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1097\/MJT.0b013e3181f62947","article-title":"Mediastinal extension of pancreatic pseudocyst\u2013a case with review of topic and management guidelines","volume":"19","author":"Ajmera","year":"2012","journal-title":"Am J Ther"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e00016","DOI":"10.14309\/crj.0000000000000016","article-title":"Endoscopic cyst esophagostomy using a lumen-apposing stent for a large mediastinal pancreatic pseudocyst compressing the left atrium","volume":"6","author":"Aziz","year":"2019","journal-title":"ACG Case Rep J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2058460116647213","DOI":"10.1177\/2058460116647213","article-title":"Three cases of mediastinal pancreatic pseudocysts","volume":"5","author":"Matsusue","year":"2016","journal-title":"Acta Radiol Open"},{"key":"B6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s13312-018-1327-z","article-title":"Isolated mediastinal pseudocyst of the pancreas","volume":"55","author":"Halder","year":"2018","journal-title":"Indian Pediatr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.5946\/ce.2016.089","article-title":"Mediastinal pancreatic pseudocysts","volume":"50","author":"D\u0105bkowski","year":"2017","journal-title":"Clin Endosc"},{"key":"B8","first-page":"188","article-title":"A case of mediastinal pancreatic pseudocysts which ruptured into the pleural cavity and emerged pancreatic pleural effusion","volume":"101","author":"Sawada","year":"2004","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"B9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1752-1947-1-12","article-title":"Mediastinal extension of a complicated pancreatic pseudocyst; a case report and literature review","volume":"1","author":"Sadat","year":"2007","journal-title":"J Med Case Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.2169\/internalmedicine.48.2360","article-title":"Mediastinal pancreatic pseudocysts that were resolved following parathyroidectomy for primary hyperparathyroidism","volume":"48","author":"Takimoto","year":"2009","journal-title":"Intern Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.6092\/1590-8577\/2904","article-title":"Surgical intervention for mediastinal pancreatic pseudocysts. 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