{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:29Z","timestamp":1787027009998,"version":"build-2736575974"},"reference-count":186,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    Invasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality.\n                    <jats:italic>Candida<\/jats:italic>\n                    species (\n                    <jats:italic>Candida<\/jats:italic>\n                    spp.) are the major fungal pathogens, which cause the so-called invasive\n                    <jats:italic>Candida<\/jats:italic>\n                    infections (ICIs). Of these,\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is the most commonly isolated species, followed by\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    . Other identified\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. include\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    ,\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    ,\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    , etc. However, an increasing shift in the epidemiology of ICIs worldwide has been described, non-\n                    <jats:italic>albicans Candida<\/jats:italic>\n                    (NAC) spp. ICIs pose a growing threat to neonates. Herein, we examine the epidemiology of\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. infections, patterns of antifungal resistance, risk factors, prevention strategies, clinical outcomes, and treatment recommendations for ICIs in hospitalized newborn infants. This review aims to provide a thorough understanding of the current evidence on ICIs to better inform targeted prevention strategies and improved treatments to reduce neonatal morbidity and mortality.\n                  <\/jats:p>","DOI":"10.3389\/fped.2025.1613832","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T12:19:24Z","timestamp":1752841164000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Addressing the silent threat: managing invasive Candida infections in hospitalized newborns"],"prefix":"10.3389","volume":"13","author":[{"given":"Deshuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongke","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"726769","DOI":"10.3389\/fped.2021.726769","article-title":"Prophylactic 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