{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:35:54Z","timestamp":1790094954685,"version":"4.0.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Talaromyces marneffei<\/jats:italic> (<jats:italic>T. marneffei<\/jats:italic>) is a pathogenic yeast that causes high fatality rates among immunocompromised individuals. The organism appears to target the lungs, liver, gut-associated lymphoid tissues, lymph nodes, spleen, bone marrow, kidneys, and the tonsils in the affected individuals. Evidence suggests that the lungs and liver are seriously injured in <jats:italic>T. marneffei<\/jats:italic> infections. Injuries to the pharyngeal and laryngeal compartments have seldom been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>Three pediatric patients with <jats:italic>T. marneffei<\/jats:italic> infections were admitted to the Guangzhou Women and Children's Center between August 2015 and March 2023. All three children showed evidence of pharyngeal and laryngeal injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Damage to the pharyngeal and laryngeal compartments appears to be an important clinical manifestation among HIV-negative pediatric individuals with a <jats:italic>T. marneffei<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1615943","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:27:35Z","timestamp":1759987655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Talaromyces marneffei infections associated with pharyngeal and laryngeal injuries in three children with aberrant innate immunity: a case 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