{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:14Z","timestamp":1753891874101,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal intracardiac masses are rare and pose significant diagnostic and therapeutic challenges, particularly in differentiating thrombi from tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>We present the case of a preterm neonate with a right atrial mass of uncertain etiology. Multimodal imaging, including echocardiography and cardiac MRI, suggested the presence of a thrombus\u2014consistent with thrombi being the most common type of intracavitary cardiac mass. As a result, primary anticoagulation therapy was initiated. However, after 16 days without significant change in the mass and given the high risk of embolization and the possibility of a benign tumor, surgical excision was performed. Histopathological analysis of the excised tissue could not definitively distinguish between an organized thrombus and a regressed benign neoplasm, although no malignant cells were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case highlights the diagnostic uncertainty surrounding neonatal intracardiac masses and the limitations of imaging and pathology in achieving definitive diagnosis. A multidisciplinary approach and long-term follow-up are essential, particularly when the true nature of the mass remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1621500","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:53:45Z","timestamp":1751435625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Neonatal right atrial mass of uncertain etiology"],"prefix":"10.3389","volume":"13","author":[{"given":"Libor","family":"Svoboda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Mank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Vollroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kiess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sch\u00fcrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0002-9149(68)90140-9","article-title":"Cardiac tumors in infancy","volume":"21","author":"Nadas","year":"1968","journal-title":"Am J Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1093\/eurheartj\/ehad655.1895","article-title":"The prevalence of congenital cardiac tumours in unselected newborns","volume":"44","author":"Sillesen","year":"2023","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1136\/adc.68.3.367","article-title":"Cardiac rhabdomyomas and their association with tuberous sclerosis","volume":"68","author":"Webb","year":"1993","journal-title":"Arch Dis Child"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1016\/j.athoracsur.2016.04.057","article-title":"Primary cardiac tumors in infants and children: surgical strategy and long-term outcome","volume":"102","author":"Delmo Walter","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/S0022-5223(19)37924-3","article-title":"Primary cardiac tumors in children","volume":"79","author":"Arciniegas","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00246-003-0590-4","article-title":"Fetal and neonatal cardiac tumors","volume":"25","author":"Isaacs","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1136\/hrt.48.2.177","article-title":"Large calcified right atrial myxoma in a newborn. Rare cause of neonatal death","volume":"48","author":"Dianzumba","year":"1982","journal-title":"Br Heart J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.23907\/2017.013","article-title":"Primary cardiac tumors in infancy: a case report and literature review","volume":"7","author":"Dominguez","year":"2017","journal-title":"Acad Forensic Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/diagnostics13040764","article-title":"Intracardiac thrombi in preterm infants-A case study and review of the literature","volume":"13","author":"Gover","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"13864","DOI":"10.3390\/ijms241813864","article-title":"The hemostatic system in newborns and the risk of neonatal thrombosis","volume":"24","author":"Khizroeva","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-29489-6_239","article-title":"The thrombotic risk of the newborn","volume-title":"Neonatology","author":"Angelo Claudio","year":"2018"},{"key":"B12","doi-asserted-by":"publisher","first-page":"102266","DOI":"10.1016\/j.rpth.2023.102266","article-title":"Intracardiac thrombi in pediatrics: anticoagulation approach and treatment outcomes","volume":"7","author":"Agarwal","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"B13","doi-asserted-by":"publisher","first-page":"Q70","DOI":"10.1186\/1532-429X-17-S1-Q70","article-title":"The accuracy of cardiac MRI in differentiating between intra cardiac tumors and thrombi","volume":"17","author":"Goitein","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"key":"B14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/jcecho.jcecho_18_22","article-title":"Imaging of cardiac masses","volume":"32","author":"Parato","year":"2022","journal-title":"J Cardiovasc Echogr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e230010","DOI":"10.1148\/rg.230010","article-title":"Cardiac and pericardial neoplasms in children: radiologic-pathologic correlation","volume":"43","author":"Medina Perez","year":"2023","journal-title":"Radiographics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e29955","DOI":"10.1002\/pbc.29955","article-title":"Imaging of pediatric cardiac tumors: a COG diagnostic imaging committee\/SPR oncology committee white paper","author":"Morin","year":"2023","journal-title":"Pediatr Blood Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1055\/s-0034-1396567","article-title":"Atrial thrombus in a neonate: a diagnostic challenge","volume":"5","author":"Sheen","year":"2015","journal-title":"AJP Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e250424229325","DOI":"10.2174\/011573403X281926240417110330","article-title":"Atrial thrombus or atrial myxoma? Preliminary analysis of echocardiographic findings of a case series","volume":"20","author":"Hu","year":"2024","journal-title":"Curr Cardiol Rev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.2214\/AJR.08.1895","article-title":"Cardiac tumors: optimal cardiac MR sequences and spectrum of imaging appearances","volume":"193","author":"O'Donnell","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"S154","DOI":"10.4103\/mjdrdypu.mjdrdypu_595_22","article-title":"Cardiac distress in an infant\u2014giant right atrial myxoma obstructing right ventricular inflow and causing cardiac arrest","volume":"16","author":"Pawar","year":"2023","journal-title":"Med J Dr. D.Y. Patil Vidyapeeth"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1002\/ccr3.3396","article-title":"Right atrial thrombus mimicking cardiac tumor in a neonate","volume":"8","author":"Samanidis","year":"2020","journal-title":"Clin Case Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijscr.2017.05.036","article-title":"Obstructive neonatal atrial myxoma","volume":"37","author":"Iezzi","year":"2017","journal-title":"Int J Surg Case Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e108029","DOI":"10.5812\/pedinfect.108029","article-title":"Left atrial myxoma misdiagnosis as infective endocarditis: a case report","volume":"9","author":"Rafi Khourgami","year":"2020","journal-title":"Arch Pediatr Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1177\/1066896918768029","article-title":"Myxoid emboli","volume":"26","author":"AbdullGaffar","year":"2018","journal-title":"Int J Surg Pathol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11886-020-01420-z","article-title":"Cardiac tumors: diagnosis, prognosis, and treatment","volume":"22","author":"Bussani","year":"2020","journal-title":"Curr Cardiol Rep"},{"key":"B26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1750-1172-2-11","article-title":"Cardiac tumours in children","volume":"2","author":"Uzun","year":"2007","journal-title":"Orphanet J Rare Dis"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1621500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:53:46Z","timestamp":1751435626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1621500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":26,"alternative-id":["10.3389\/fped.2025.1621500"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1621500","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"article-number":"1621500"}}