{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:52:50Z","timestamp":1759333970176,"version":"build-2065373602"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In newborns, infantile hemangiomas (IHs) in the airway can present with rare life-threatening complications associated with airway obstruction, even without cutaneous hemangioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>Our female newborn exhibited stridor 1\u2005day after her birth. Furthermore, 7\u2005days after birth, she was admitted to the local hospital to receive phototherapy for neonatal jaundice. However, her stridor was not noted as being related to IH by the clinician during her hospitalization. She was transferred to our hospital at 14\u2005days old because her stridor and condition deteriorated with severe breathlessness and respiratory failure. Computed tomography and flexible bronchoscopy identified obstructive airway IHs. Although a combination therapy of propranolol and corticosteroids was prescribed for 2\u2005weeks, she still needed invasive mechanical ventilation. After a discussion by the multidisciplinary team, endoscopic resection was carried out to resolve her airway obstruction at 30\u2005days old, but it failed. Finally, transcatheter interventional sclerotherapy successfully resolved her clinical conditions at 60\u2005days old. She was discharged and received follow-up with propranolol treatment. Her clinical symptoms of airway IHs were completely resolved 1\u2005year later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Airway IHs can rarely present with life-threatening conditions associated with airway obstruction without cutaneous hemangioma in newborns. This case report highlights that propranolol is the cornerstone treatment for airway IHs. For the first time, our findings suggest that transcatheter interventional sclerotherapy can be a valid additional treatment option.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1631906","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:28:14Z","timestamp":1759210094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Airway obstruction as a fatal complication of infantile hemangioma in newborns: the eye cannot see what the mind does not know"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoliang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaoJiao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanrui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e172836","DOI":"10.1172\/jci172836","article-title":"Infantile hemangioma: the common and enigmatic vascular tumor","volume":"134","author":"Holm","year":"2024","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.jaad.2021.08.019","article-title":"Infantile hemangioma. 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