{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:46:07Z","timestamp":1788918367999,"version":"build-2803163510"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (MPP) is a common cause of pediatric community-acquired pneumonia, and coinfections with\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      (Hi) or influenza virus may alter disease severity. Identifying distinct laboratory patterns may help clinicians recognise coinfections early.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 140 hospitalized children with confirmed MPP (2014\u20132024). Patients were grouped as MPP alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964), MPP+Hi (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936), and MPP+influenza (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). Clinical characteristics, complete blood count (CBC), hypersensitive C-reactive protein (hs-CRP), and biochemical indicators (ALT, AST, CK, CK-MB, urea, creatinine) were compared among groups. Correlation analyses were performed for biochemical markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children with MPP+Hi showed the highest hs-CRP levels (23.93\u2009\u00b1\u200921.26 mg\/L), longest fever duration, and longest hospital stay. The MPP+influenza group had significantly lower WBC (7.25\u2009\u00b1\u20093.50\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and platelet counts (266.00\u2009\u00b1\u200997.46\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L), and a higher monocyte percentage (10.18\u2009\u00b1\u20093.29%). Simple MPP cases had the highest lymphocyte percentage. No group differences were found in ALT, AST, CK, CK-MB, urea, or creatinine, although CK-MB was elevated across all groups. Correlation analysis showed weak but significant associations among AST, ALT, CK, and CK-MB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Coinfection type influenced inflammatory and haematological patterns in children with MPP: Hi coinfection produced stronger inflammatory responses, while influenza coinfection showed viral-associated lymphopenia and thrombocytopenia. Routine laboratory parameters may support earlier recognition of coinfections and guide more targeted clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1661684","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:29:46Z","timestamp":1763965786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of blood routine, C-reactive protein, and biochemical markers in children with Mycoplasma pneumoniae pneumonia and its 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