{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T04:41:58Z","timestamp":1760589718760,"version":"build-2065373602"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the risk factors associated with mortality in infants born at 22\u201323 weeks and assessed the impact of different variables on survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 185 infants born at 22\u201323 weeks at a single tertiary care center (2006\u20132023). Univariate and logistic regression analyses identified independent predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 185 infants, 64 (34.6%) did not survive. Mortality was associated with a lower birth weight (509 g vs. 564\u2005g, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001) and higher rates of small for gestational age (SGA; 21.9% vs. 7.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Independent predictors included SGA [odds ratio (OR): 5.8], tension pneumothorax (OR: 9.9), severe intraventricular hemorrhage (OR: 3.3), focal intestinal perforation (OR: 4.1), necrotizing enterocolitis (OR: 18.9), and early-onset sepsis (OR: 9.7). Cesarean delivery was associated with reduced mortality (OR: 0.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Targeted management of these risk factors and cesarean delivery may improve the outcomes in this population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2025.1673565","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T04:18:32Z","timestamp":1760588312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of survival in extremely preterm infants born at 22\u201323 weeks: a retrospective cohort 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