{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:27:11Z","timestamp":1761805631542,"version":"build-2065373602"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lead is an environmental toxin that may cause severe damage to vital organs including the brain, kidneys, liver, and bones. Children are particularly susceptible due to higher rates of gastrointestinal absorption and detrimental effects of lead on their developing nervous systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This report highlights the case of a 4-year-old boy with severe lead poisoning resulting from prolonged exposure to ayurvedic herbal supplements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The child was initially admitted with anemia, arterial hypertension, abdominal pain, and mild neurological impairment. His blood smear revealed pronounced basophilic stippling of erythrocytes. His venous blood lead level (BLL) was markedly elevated at 123\u2005\u03bcg\/dl. Detailed review of his history uncovered that he had been ingesting an ayurvedic herbal medicine for asthma. He received chelation therapy with 2,3-dimercapto-1-propanesulfonic acid and calcium disodium EDTA, resulting in rapid resolution of symptoms and gradually decreasing BLLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The case is a striking example of the significant health risks due to heavy metal contamination in ayurveda products. Better strategies to control the composition of ayurvedic products and educate families about their possible heavy metal contamination are essential to reduce the risk of lead poisoning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1692561","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:22:17Z","timestamp":1761805337000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Severe lead poisoning due to exposure to ayurvedic herbal medicine"],"prefix":"10.3389","volume":"13","author":[{"given":"Gabriella","family":"Cericola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Puzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Salou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayami","family":"Yoshimi-N\u00f6llke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Niemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Feuchtinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Henretig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Krell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Hettmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"B1","article-title":"Metal toxicity from ayurvedic medications\u2014MN Dept. of Health","year":""},{"key":"B2","article-title":"The toxic truth: children\u2019s exposure to lead pollution undermines a generation of future potential, UNICEF","author":"Choi","year":""},{"key":"B3","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.15585\/mmwr.mm7043a4","article-title":"Update of the blood lead reference value\u2014United States, 2021","volume":"70","author":"Ruckart","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B4","article-title":"Lead poisoning","year":""},{"key":"B5","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1001\/jama.300.8.915","article-title":"Lead, mercury, and arsenic in US- and Indian-manufactured ayurvedic medicines sold via the internet","volume":"300","author":"Saper","year":"2008","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1056\/NEJMra2402527","article-title":"Lead poisoning","volume":"391","author":"Lanphear","year":"2024","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","author":"J\u00e4rup","year":"2024","journal-title":"Br Med Bull"},{"key":"B8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.5863\/1551-6776-29.3.212","article-title":"Lead exposure in children: failure to protect the most vulnerable","volume":"29","author":"Sample","year":"2024","journal-title":"J Pediatr Pharmacol Ther"},{"key":"B9","doi-asserted-by":"publisher","first-page":"14225","DOI":"10.1038\/s41598-019-50654-7","article-title":"A pharmacokinetic model of lead absorption and calcium competitive dynamics","volume":"9","author":"R\u0103dulescu","year":"2019","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"048001","DOI":"10.1289\/EHP14809","article-title":"Comment on \u201cneurotoxicity and outcomes from developmental lead exposure: persistent or permanent?\u201d","volume":"132","author":"Neuwirth","year":"2024","journal-title":"Environ Health Perspect"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1692561\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:22:18Z","timestamp":1761805338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1692561\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":10,"alternative-id":["10.3389\/fped.2025.1692561"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1692561","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"article-number":"1692561"}}