{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:28:52Z","timestamp":1764052132598,"version":"3.45.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the impact of delayed cord clamping (DCC) on the levels of blood mesenchymal (MSCs), hemopoietic progenitor (HPCs), and immune cells in very preterm neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively examined 21 neonates with a median gestational age of 32 weeks (interquartile range, IQR 29\u201332) who had DCC, and 19 neonates with a median gestational age of 31 weeks (IQR 30\u201332) who had immediate cord clamping (ICC). We measured the levels of MSCs, HPCs, very small embryonic-like stem cells (VSELs), early endothelial progenitor cells (EPCs), late EPCs, and the immunophenotype in the first, 10th, and 30th day of life, and associated them with late-onset sepsis and bronchopulmonary dysplasia (BPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DCC-neonates compared to ICC-neonates had significantly higher values of MSCs (846 vs. 316 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), HPCs (191 vs. 115 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), and lower values of VSELs (21 vs. 37 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and late EPCs (7 vs. 19 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) at birth. Neonates with late-onset sepsis, in comparison to neonates with no sepsis, had significantly higher values of early (20 vs. 0.3 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and late EPCs (32 vs. 8 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). In addition, neonates with BPD had significantly higher values of late EPCs compared to neonates without BPD (27 vs. 8 cells per million cytometric events,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). DCC, adjusted for gestational age and birth weight, was significantly associated with higher levels of MSCs, HPCs, and lower levels of VSELs and late EPCs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In very preterm neonates with DCC, MSCs and HPCs are higher, while VSELs and late EPCs are lower in the umbilical cord blood, compared to neonates with ICC. Early and late EPCs were associated with late-onset sepsis and BPD. Further studies are warranted to explore the association of these findings with the long-term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1698512","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:25:25Z","timestamp":1764051925000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of delayed cord clamping on mesenchymal, hemopoietic progenitor, and immune cells in very preterm neonates"],"prefix":"10.3389","volume":"13","author":[{"given":"Eftychia","family":"Drogouti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Rallis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Fleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Giannakou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Lithoxopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kavga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Themistoklis","family":"Mikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Soubasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisavet","family":"Diamanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Roilides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Tsakalidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.4103\/1673-5374.165218","article-title":"Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping","volume":"10","author":"Lawton","year":"2015","journal-title":"Neural Regen Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/AOG.0000000000006020","article-title":"ACOG clinical practice update: an update to clinical guidance for delayed umbilical cord clamping after birth in preterm neonates","volume":"146","year":"2025","journal-title":"Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/14651858.CD004074.pub3","article-title":"Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes","volume":"2015","author":"McDonald","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/14651858.CD003248.pub4","article-title":"Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes","volume":"2019","author":"Rabe","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/pr.2017.251","article-title":"From cord to caudate: characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain","volume":"83","author":"Maillacheruvu","year":"2017","journal-title":"Pediatr Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1582-4934.2010.01029.x","article-title":"Mankind\u2019s first natural stem cell transplant","volume":"14","author":"Tolosa","year":"2010","journal-title":"J Cell Mol Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/s0140-6736(69)92328-9","article-title":"Distribution of blood between infant and placenta after birth","volume":"294","author":"Yao","year":"1969","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1182\/blood-2006-08-043471","article-title":"Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem\/progenitor cell principals","volume":"109","author":"Yoder","year":"2006","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00277-004-0918-z","article-title":"Mesenchymal progenitor cells in the human umbilical cord","volume":"83","author":"Kim","year":"2004","journal-title":"Ann Hematol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1080\/14653240600941549","article-title":"Differentiation of umbilical cord blood-derived multilineage progenitor cells into respiratory epithelial cells","volume":"8","author":"Berger","year":"2006","journal-title":"Cytotherapy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jcyt.2014.08.009","article-title":"Discarded wharton jelly of the human umbilical cord: a viable source for mesenchymal stromal cells","volume":"17","author":"Watson","year":"2015","journal-title":"Cytotherapy"},{"key":"B12","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1203\/00006450-199605000-00013","article-title":"The highest concentration of primitive hematopoietic progenitor cells in cord blood is found in extremely premature infants","volume":"39","author":"Haneline","year":"1996","journal-title":"Pediatr Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00431-020-03730-4","article-title":"Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial","volume":"180","author":"Yunis","year":"2020","journal-title":"Eur J Pediatr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2022.838444","article-title":"Effects of umbilical cord management strategies on stem cell transfusion, delivery room adaptation, and cerebral oxygenation in term and late preterm infants","volume":"10","author":"Okulu","year":"2022","journal-title":"Front Pediatr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1515\/jpm.2011.021","article-title":"Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates","volume":"39","author":"Gokmen","year":"2011","journal-title":"J Perinat Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1183\/09031936.00017312","article-title":"Cord blood angiogenic progenitor cells are decreased in bronchopulmonary dysplasia","volume":"40","author":"Baker","year":"2012","journal-title":"Eur Respir J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1164\/rccm.200812-1949OC","article-title":"Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia","volume":"180","author":"Borghesi","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.earlhumdev.2012.12.006","article-title":"Circulating hematopoietic and endothelial progenitor cells in newborn infants: effects of gestational age, postnatal age and clinical stress in the first 3weeks of life","volume":"89","author":"Bui","year":"2013","journal-title":"Early Hum Dev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0079060","article-title":"Circulating endothelial progenitor cells decrease in infants with bronchopulmonary dysplasia and increase after inhaled nitric oxide","volume":"8","author":"Qi","year":"2013","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1515\/jpm-2011-0199","article-title":"Circulating endothelial progenitor cells in premature infants: is there an association with premature birth complications?","volume":"40","author":"Safranow","year":"2012","journal-title":"J Perinat Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1177\/039463201302600330","article-title":"Different subsets of circulating angiogenic cells do not predict bronchopulmonary dysplasia or other diseases of prematurity in preterm infants","volume":"26","author":"Borghesi","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.earlhumdev.2011.03.011","article-title":"Endothelial progenitor cells, bronchopulmonary dysplasia and other short-term outcomes of extremely preterm birth","volume":"87","author":"Paviotti","year":"2011","journal-title":"Early Hum Dev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1097\/aog.0000000000005593","article-title":"Acog clinical practice update: update on criteria for suspected diagnosis of intraamniotic infection","volume":"144","year":"2024","journal-title":"Obstet Gynecol"},{"key":"B24","volume-title":"Manual of Operations: Part 2 Data Definitions & Infant Data Booklets","year":"2024"},{"key":"B25","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1164\/rccm.201812-2348OC","article-title":"The diagnosis of bronchopulmonary dysplasia in very preterm infants. An evidence-based approach","volume":"200","author":"Jensen","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1414-431X2024e13457","article-title":"Mesenchymal stem cells from different sources for sepsis treatment: prospects and limitations","volume":"57","author":"Chen","year":"2024","journal-title":"Braz J Med Biol Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00018-017-2665-z","article-title":"Mesenchymal stem cells from preterm to term newborns undergo a significant switch from anaerobic glycolysis to the oxidative phosphorylation","volume":"75","author":"Ravera","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.jcyt.2014.06.004","article-title":"Cell-based therapies for the preterm infant","volume":"16","author":"Zhu","year":"2014","journal-title":"Cytotherapy"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2020.591693","article-title":"The potential of mesenchymal stromal cell as therapy in neonatal diseases","volume":"8","author":"Liau","year":"2020","journal-title":"Front Pediatr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jcyt.2023.01.001","article-title":"Feasibility of cord blood collection for autologous cell therapy applications in extremely preterm infants","volume":"25","author":"Zhou","year":"2023","journal-title":"Cytotherapy"},{"key":"B31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1203\/PDR.0b013e31817445e9","article-title":"Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood","volume":"64","author":"Javed","year":"2008","journal-title":"Pediatr Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s43032-022-01129-0","article-title":"Mesenchymal stem cell identification after delayed cord clamping","volume":"30","author":"Smith","year":"2022","journal-title":"Reprod Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/science.aal2379","article-title":"Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology","volume":"357","author":"Augustin","year":"2017","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1002\/stem.745","article-title":"Concise review: circulating endothelial progenitor cells for vascular medicine","volume":"29","author":"Asahara","year":"2011","journal-title":"Stem Cells"},{"key":"B35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/B978-0-12-385493-3.00003-6","article-title":"Identification of very small embryonic\/epiblast-like stem cells (VSELs) circulating in peripheral blood during organ\/tissue injuries. Recent advances in cytometry, part B\u2014advances in applications","volume":"103","author":"Ratajczak","year":"2011","journal-title":"Methods Cell Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/5756901","article-title":"Endurance exercise mobilizes developmentally early stem cells into peripheral blood and increases their number in bone marrow: implications for tissue regeneration","volume":"2016","author":"Marycz","year":"2015","journal-title":"Stem Cells Int"},{"key":"B37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s12015-011-9272-4","article-title":"Stem cells, including a population of very small embryonic-like stem cells, are mobilized into peripheral blood in patients after skin burn injury","volume":"8","author":"Druka\u0142a","year":"2011","journal-title":"Stem Cell Rev Rep"},{"key":"B38","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1542\/peds.2004-1238","article-title":"Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung disease","volume":"115","author":"Doyle","year":"2005","journal-title":"Pediatrics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3727\/096368909(471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1210\/jcem.81.3.8772609","article-title":"The expression of stem cell factor and its receptor, C-kit in human endometrium and placental tissues during pregnancy","volume":"81","author":"Kauma","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1089\/08892220050075372","article-title":"Letter to the editor: sdf-1 production by placental cells: a potential mechanism of inhibition of mother-to-Fetus HIV transmission","volume":"16","author":"Coulomb-L\u2019Hermine","year":"2000","journal-title":"AIDS Res Hum Retrovir"},{"key":"B42","doi-asserted-by":"publisher","first-page":"214","DOI":"10.5152\/TurkPediatriArs.2018.6900","article-title":"The effects of umblical cord clamping time on lymphocyte subgroups in term and late preterm infants","volume":"53","author":"Bahar","year":"2019","journal-title":"T\u00fcrk Pediatri Ar\u015fivi"},{"key":"B43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1203\/00006450-198805000-00003","article-title":"Analysis of lymphocyte proliferative response subpopulations in very low birth weight infants and during the first 8 weeks of life","volume":"23","author":"Bussel","year":"1988","journal-title":"Pediatr Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/s2352-4642(21)00373-4","article-title":"Effects of delayed versus immediate umbilical cord clamping in reducing death or major disability at 2 years corrected age among very preterm infants (APTS): a multicentre, randomised clinical trial","volume":"6","author":"Robledo","year":"2022","journal-title":"Lancet Child Adolesc Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-50100-9","article-title":"Effect of different timings of umbilical cord clamping on the level of Cd34+ cells in full-term neonates","volume":"13","author":"Korkor","year":"2023","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s10753-008-9068-0","article-title":"Neonates with culture proven sepsis have lower amounts and percentage of Cd45ra+ T cells","volume":"31","author":"Aygun","year":"2008","journal-title":"Inflammation"},{"key":"B47","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cytogfr.2023.08.008","article-title":"Multifaceted role of CD14 in innate immunity and tissue homeostasis","volume":"74","author":"Na","year":"2023","journal-title":"Cytokine Growth Factor Rev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/s41418-022-00931-2","article-title":"Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by Cd14","volume":"29","author":"Kim","year":"2022","journal-title":"Cell Death Differ"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1084\/jem.20202345","article-title":"Single-cell analysis of human skin identifies Cd14+ type 3 dendritic cells co-producing Il1b and Il23a in psoriasis","volume":"218","author":"Nakamizo","year":"2021","journal-title":"J Exp Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1002\/stem.1413","article-title":"Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung","volume":"31","author":"Jin","year":"2013","journal-title":"Stem Cells"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1164\/ajrccm.164.10.2109111c","article-title":"Bronchopulmonary dysplasia","volume":"164","author":"Abman","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","article-title":"Bronchopulmonary dysplasia","volume":"175","author":"Th\u00e9baud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nm0603-702","article-title":"Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration","volume":"9","author":"Rafii","year":"2003","journal-title":"Nat Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1164\/rccm.200901-0115OC","article-title":"Endothelial colony-forming cells from preterm infants are increased and more susceptible to hyperoxia","volume":"180","author":"Baker","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2989076","article-title":"Effects of oxidative stress on mesenchymal stem cell biology","volume":"2016","author":"Denu","year":"2016","journal-title":"Oxid Med Cell Longevity"},{"key":"B56","doi-asserted-by":"publisher","first-page":"24542","DOI":"10.18632\/aging.203724","article-title":"Increased proliferation and differentiation capacity of placenta-derived mesenchymal stem cells from women of median maternal age correlates with telomere shortening","volume":"13","author":"Guerrero","year":"2021","journal-title":"Aging"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/sj.bmt.1702729","article-title":"Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units","volume":"27","author":"Ballen","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"B58","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1447-0756.2007.00555.x","article-title":"Decrease and dysfunction of endothelial progenitor cells in umbilical cord blood with maternal pre-eclampsia","volume":"33","author":"Xia","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-0897.2006.00387.x","article-title":"Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia","volume":"56","author":"Matsubara","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2017.09.002","article-title":"Mesenchymal stromal cells isolated from gestationally diabetic human placenta exhibit insulin resistance, decreased clonogenicity and angiogenesis","volume":"59","author":"Mathew","year":"2017","journal-title":"Placenta"},{"key":"B61","doi-asserted-by":"publisher","first-page":"451","DOI":"10.5966\/sctm.2015-0155","article-title":"Impaired angiogenic potential of human placental mesenchymal stromal cells in intrauterine growth restriction","volume":"5","author":"Mand\u00f2","year":"2016","journal-title":"Stem Cells Transl Med"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1698512\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:25:26Z","timestamp":1764051926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1698512\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":61,"alternative-id":["10.3389\/fped.2025.1698512"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1698512","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"1698512"}}