{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:01:10Z","timestamp":1792555270338,"version":"4.5.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute gastric volvulus is a rare condition in children, and delayed diagnosis may lead to gastric ischemia, perforation, or even death. It is sometimes associated with a wandering spleen, a condition in which the spleen migrates from its normal anatomical position due to the absence of fixation ligaments. We report the first known case of a patient with Pitt\u2013Hopkins syndrome (PTHS) presenting with simultaneous acute gastric volvulus and a wandering spleen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 6-year-old male with PTHS was urgently referred for acute abdominal pain and a 24\u2005h history of non-bilious and non-bloody emesis. The x-ray showed a massive gastric dilatation, and an upper gastrointestinal series (UGI) revealed a gastric outlet obstruction. An emergency laparoscopy revealed a gastric mesoaxial volvulus with a hypotonic wall with no sign of ischemia or perforation associated with a wandering spleen. Gastropexy was performed by anchoring the gastric greater curvature to the anterior abdominal wall, covering the spleen in a good position in the left upper abdomen, completely covered by the gastric fundus. The patient made an uneventful recovery and was completely asymptomatic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, this is the first reported case of simultaneous gastric volvulus and wandering spleen in a patient with PTHS. Laparoscopic gastropexy is a straightforward and effective procedure that combines the advantages of previously described surgical techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1705547","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:26:07Z","timestamp":1764051967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastric volvulus and wandering spleen in Pitt\u2013Hopkins syndrome: first paediatric case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Gabriele","family":"Vasta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Angotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Contini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Perrotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tarallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Plessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Briganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e752","DOI":"10.1542\/peds.2007-3111","article-title":"Gastric volvulus in infants and children","volume":"122","author":"Cribbs","year":"2008","journal-title":"Pediatrics"},{"key":"B2","first-page":"131","article-title":"Volvulus of the stomach: case report and survey","volume":"103","author":"Dalgaard","year":"1952","journal-title":"Acta Chir Scand"},{"key":"B3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0140-6736(58)92518-2","article-title":"Torsion of the stomach as a cause of vomiting in infancy","volume":"1","author":"Eek","year":"1958","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X241262141","article-title":"Gastric volvulus with necrosis and gangrene associated with wandering spleen: a rare case report from Syria","volume":"12","author":"Hanifa","year":"2024","journal-title":"SAGE Open Med Case Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"109338","DOI":"10.1016\/j.ijscr.2024.109338","article-title":"Gastric volvulus and splenopancreatic torsion with wandering spleen: a case report","volume":"116","author":"Belayneh","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"B6","doi-asserted-by":"crossref","first-page":"e258235","DOI":"10.1136\/bcr-2023-258235","article-title":"Mesenteroaxial volvulus due to wandering spleen: a unique repair via mesenteric splenopexy and gastropexy","volume":"16","author":"Chopko","year":"2023","journal-title":"BMJ Case Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2147\/CEG.S428679","article-title":"Wandering spleen and acute gastric volvulus in an elderly woman with acute abdomen: a case report","volume":"16","author":"Basu","year":"2023","journal-title":"Clin Exp Gastroenterol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e38386","DOI":"10.7759\/cureus.38386","article-title":"Acute gastric volvulus with wandering spleen in a two-year-old child: a rare association","volume":"15","author":"Bhambu","year":"2023","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e235918","DOI":"10.1136\/bcr-2020-235918","article-title":"Wandering spleen leading to splenic torsion with gastric and pancreatic volvulus","volume":"14","author":"Shen","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"489","DOI":"10.14744\/tjtes.2019.91606","article-title":"Torsion of wandering spleen nine years after gastric volvulus: effect of multiparity?","volume":"26","author":"Karaisli","year":"2020","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"E186","DOI":"10.1111\/ans.15966","article-title":"Atypical mesenteroaxial gastric volvulus with wandering spleen as a late complication of vagotomy and pyloromyotomy for peptic duodenal ulcer","volume":"90","author":"Mocanu","year":"2020","journal-title":"ANZ J Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/2054270419851325","article-title":"Wandering spleen in a geriatric patient\u2014a rare presentation of gastric volvulus","volume":"10","author":"Gandhi","year":"2019","journal-title":"JRSM Open"},{"key":"B13","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.radcr.2019.05.018","article-title":"Concurrent occurrence of a wandering spleen, organoaxial gastric volvulus, pancreatic volvulus, and cholestasis\u2014a rare cause of an acute abdomen","volume":"14","author":"Asafu Adjaye Frimpong","year":"2019","journal-title":"Radiol Case Rep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/BF02015024","article-title":"Wandering spleen and gastric volvulus","volume":"24","author":"Garcia","year":"1994","journal-title":"Pediatr Radiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/j.1572-0241.1998.00349.x","article-title":"Gastric volvulus and wandering spleen","volume":"93","author":"Uc","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"S137","DOI":"10.1089\/lap.2008.0091.supp","article-title":"Laparoscopic gastropexy for the treatment of gastric volvulus associated with wandering spleen","volume":"19","author":"Fran\u00e7ois-Fiquet","year":"2009","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s40792-022-01537-z","article-title":"Volvulus of the stomach and wandering spleen after repair of congenital diaphragmatic hernia: unexpected manifestations in a neonate","volume":"8","author":"Oyachi","year":"2022","journal-title":"Surg Case Rep"},{"key":"B18","doi-asserted-by":"crossref","first-page":"e242441","DOI":"10.1136\/bcr-2021-242441","article-title":"Laparoscopic management of gastric volvulus, diaphragmatic eventration and wandering spleen in a child","volume":"14","author":"Kataria","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/ases.12894","article-title":"Laparoscopic retroperitoneal splenopexy for wandering spleen: a novel technique using a three-incision retroperitoneal pouch","volume":"14","author":"Umeda","year":"2021","journal-title":"Asian J Endosc Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00383-010-2657-7","article-title":"Laparoscopic splenopexy and gastropexy for wandering spleen associated with gastric volvulus","volume":"26","author":"Okazaki","year":"2010","journal-title":"Pediatr Surg Int"},{"key":"B21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/jpc.1978.14.3.182","article-title":"A syndrome of mental retardation, wide mouth and intermittent overbreathing","volume":"14","author":"Pitt","year":"1978","journal-title":"Aust Paediatr J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/cge.13506","article-title":"Diagnosis and management in Pitt-Hopkins syndrome: first international consensus statement","volume":"95","author":"Zollino","year":"2019","journal-title":"Clin Genet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13023-016-0422-2","article-title":"Phenotype and natural history in 101 individuals with Pitt-Hopkins syndrome through an internet questionnaire system","volume":"11","author":"de Winter","year":"2016","journal-title":"Orphanet J Rare Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/aur.1467","article-title":"Pitt-Hopkins mouse model has altered particular gastrointestinal transits in vivo","volume":"8","author":"Grubi\u0161i\u0107","year":"2015","journal-title":"Autism Res"},{"key":"B25","first-page":"1780","article-title":"Acute gastric volvulus: pathogenesis, diagnosis, and treatment","volume":"88","author":"Wasselle","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijsu.2009.11.002","article-title":"A review article on gastric volvulus: a challenge to diagnosis and management","volume":"8","author":"Rashid","year":"2010","journal-title":"Int J Surg"},{"key":"B27","doi-asserted-by":"publisher","first-page":"118.e5","DOI":"10.1016\/j.ajem.2009.04.031","article-title":"Acute gastric volvulus: a rare but real surgical emergency","volume":"28","author":"Wu","year":"2010","journal-title":"Am J Emerg Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"6450765","DOI":"10.1155\/2016\/6450765","article-title":"Wandering spleen and organoaxial gastric volvulus after Morgagni hernia repair: a case report and review of the literature","volume":"2016","author":"Cantone","year":"2016","journal-title":"Case Rep Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.22470\/pemj.2021.00388","article-title":"Acute primary gastric volvulus occurring after overeating in a 12-year-old girl","volume":"8","author":"Chung","year":"2021","journal-title":"Pediatr Emerg Med J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1053\/j.gastro.2019.07.022","article-title":"Overeating and a wandering spleen: what is the link?","volume":"157","author":"De\u2019Ath","year":"2019","journal-title":"Gastroenterology"},{"key":"B31","first-page":"707","article-title":"Acute volvulus of the stomach in infants and children","volume":"70","author":"Cole","year":"1971","journal-title":"Surgery"},{"key":"B32","first-page":"225","article-title":"Volvulus of the stomach complicating eventration of the diaphragm: report of a case","volume":"41","author":"Stephenson","year":"1964","journal-title":"Am J Gastroenterol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.jpedsurg.2010.03.003","article-title":"Wandering spleen in children: multicenter retrospective study","volume":"45","author":"Fiquet-Francois","year":"2010","journal-title":"J Pediatr Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s00383-022-05125-y","article-title":"Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy","volume":"38","author":"Nakagawa","year":"2022","journal-title":"Pediatr Surg Int"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1705547\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:26:08Z","timestamp":1764051968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1705547\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":34,"alternative-id":["10.3389\/fped.2025.1705547"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1705547","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"1705547"}}