{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:43:50Z","timestamp":1765349030069,"version":"3.46.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Ileocecal valve ulceration can arise from various causes, including infections, inflammatory bowel diseases, Beh\u00e7et's disease, tumors and medications. We present a rare case of Henoch-Sch\u00f6nlein purpura (HSP)-associated ileocecal ulcer in a pediatric patient. The child initially presented with abdominal pain and subsequently developed extensive bilateral lower limb purpura on the third hospital day. Colonoscopic examination revealed erosions and shallow ulcerations localized to the ileocecal valve, with histopathological analysis revealing characteristic mucosal stromal edema and diffuse inflammatory cell infiltration. The patient exhibited marked clinical improvement following intravenous methylprednisolone pulse therapy. This case enriches the clinical spectrum of HSP and helps clinicians better understand its intestinal involvement.<\/jats:p>","DOI":"10.3389\/fped.2025.1728450","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:39:01Z","timestamp":1765348741000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unique colonoscopic manifestations in a patient with Henoch-Sch\u00f6nlein Purpura: a case report of an ileocecal valve ulcer"],"prefix":"10.3389","volume":"13","author":[{"given":"Haizhi","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1007\/s10620-006-9548-8","article-title":"Ileocecal ulcer in central China: case series","volume":"52","author":"Cai","year":"2007","journal-title":"Dig Dis Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/1751-2980.13236","article-title":"Ileocecal involvement in intestinal Beh\u00e7et\u2019s disease and Crohn\u2019s disease: comparison of clinicopathological and immunophenotypic 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